Category: 14916-65-5

Synthetic Route of 14916-65-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14916-65-5, name is 6-Nitropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a so[ution of 3.50 g (11.2 mmo[) 5,10-dioxo-5H,1OH-diimidazo[1,5-a:1?,S?-d]pyrazine-1,6-dicarbony[ dich[oride (Intermediate 001) in 60 mL THF were added 3.10 g (22.4 mmo[) 6-nitropyridin-3-amine and 5.00 mL N,N-diisopropy[ethy[amine. The resu[ting mixture was stirred for 1 hour at room temperature under an argon atmosphere.

According to the analysis of related databases, 14916-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERSTAFF, Jens; WAGNER, Sarah; BASTING, Daniel; GOLZ, Stefan; BENDER, Eckhard; LI, Volkhart Min-Jian; LIENAU, Philip; LIU, Ningshu; SIEGEL, Franziska; BAUSER, Marcus; SUeLZLE, Detlev; HOLTON, Simon; BAIRLEIN, Michaela; BUCHGRABER, Philipp; BALINT, Jozsef; WO2015/150449; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14916-65-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14916-65-5, name is 6-Nitropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a so[ution of 3.50 g (11.2 mmo[) 5,10-dioxo-5H,1OH-diimidazo[1,5-a:1?,S?-d]pyrazine-1,6-dicarbony[ dich[oride (Intermediate 001) in 60 mL THF were added 3.10 g (22.4 mmo[) 6-nitropyridin-3-amine and 5.00 mL N,N-diisopropy[ethy[amine. The resu[ting mixture was stirred for 1 hour at room temperature under an argon atmosphere.

According to the analysis of related databases, 14916-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERSTAFF, Jens; WAGNER, Sarah; BASTING, Daniel; GOLZ, Stefan; BENDER, Eckhard; LI, Volkhart Min-Jian; LIENAU, Philip; LIU, Ningshu; SIEGEL, Franziska; BAUSER, Marcus; SUeLZLE, Detlev; HOLTON, Simon; BAIRLEIN, Michaela; BUCHGRABER, Philipp; BALINT, Jozsef; WO2015/150449; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14916-65-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14916-65-5, name is 6-Nitropyridin-3-amine, molecular formula is C5H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate V-1 was synthesized through the reaction of 5-amino-2-nitropyridine with sodium azide and orthoformate and subsequent reduction with hydrogen in the presence of palladium hydroxide/activated carbon

According to the analysis of related databases, 14916-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Teijin Pharma Limited; MIZUNO, Tsuyoshi; SHIMADA, Tomohiro; UNOKI, Gen; EBISAWA, Masaru; TAKEUCHI, Susumu; MINAMIZONO, Kunio; SASAKI, Kosuke; YOKOSAKA, Takuya; IGARASHI, Junji; MARUYAMA, Akinobu; TAKAHASHI, Hiroshi; HORIE, Kyohei; SAKAI, Yuri; (447 pag.)EP3305785; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14916-65-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14916-65-5, name is 6-Nitropyridin-3-amine, molecular formula is C5H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate V-1 was synthesized through the reaction of 5-amino-2-nitropyridine with sodium azide and orthoformate and subsequent reduction with hydrogen in the presence of palladium hydroxide/activated carbon

According to the analysis of related databases, 14916-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Teijin Pharma Limited; MIZUNO, Tsuyoshi; SHIMADA, Tomohiro; UNOKI, Gen; EBISAWA, Masaru; TAKEUCHI, Susumu; MINAMIZONO, Kunio; SASAKI, Kosuke; YOKOSAKA, Takuya; IGARASHI, Junji; MARUYAMA, Akinobu; TAKAHASHI, Hiroshi; HORIE, Kyohei; SAKAI, Yuri; (447 pag.)EP3305785; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 14916-65-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14916-65-5, name is 6-Nitropyridin-3-amine, molecular formula is C5H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-chlorobenzaldehyde (84.3 g, 0.6 mol) 5-amino-2-nitropyridine (70.0 g, 0.5 mol) and acetic acid (7.2 g, 0.12 mol) were dissolved in ethanol (350 ml) and stirred at room temperature for 1 hour. The reaction system was heated to reflux and TLC was detected.After completion of the reaction, the reaction solution was cooled to room temperature and then filtered, and the filter cake was washed with ethanol (100 mL x 3)The crude oil was recrystallized to give yellow solid compound 28 (104.6 g, yield 80%).

According to the analysis of related databases, 14916-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Haoyuan Bio-pharmaceutical Technology Co., Ltd.; Shanghai Haoyuan Pharmaceutical Co., Ltd.; Xia Junwei; Xun Hengqiao; Wang Yefa; Zhou Zhiguo; Gao Qiang; Zheng Baofu; (20 pag.)CN105017219; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 14916-65-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14916-65-5, name is 6-Nitropyridin-3-amine. A new synthetic method of this compound is introduced below.

To a solution of 6-nitro-pyridin-3-ylamine (50 mg, 0.33 mmol) in DMF (3 mL) was added NaH (60% in mineral oil, 25 mg, 0.66 mmol), and the mixture was stirred at r.t for 30 min. Then 5-bromo-2-methoxy-benzenesulfonyl chloride (86 mg, 0.3 mmol) was added and the mixture was stirred at 50 C overnight. TLC showed that the reaction was complete. The resultant was concentrated in vacuum to remove DMF. The residue was diluted with DCM (30 mL) and the mixture was washed with IN HC1 (30 mL x3) .The organic layer dried over Na2S04 and concentrated to dryness in vacuum. The residue was purified by silica gel column (PE/EtOAc, 1/1) to give 30 mg (yield: 26%) of 5-bromo-2-methoxy-N-(6-nitro-pyridin-3-yl)- benzenesulfonamide as a brown solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14916-65-5, 6-Nitropyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; DAHL, Russell; COSFORD, Nicholas, D.P.; MILLAN, Jose, Luis; WO2013/126608; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 14916-65-5, 6-Nitropyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 14916-65-5, blongs to pyridine-derivatives compound. SDS of cas: 14916-65-5

Dichloromethane 10 ml, 2-nitro 5-aminopyridine (200 mg, 1.4 mmol) starting material 1 and ethyl 4-bromo-2-oxo-butyrate (280 ml, 1.4 mmol) were added to a 50 ml reaction flask at room temperature. The magnetic stirring reaction was performed for 1 to 2 hours, and the solvent was concentrated under reduced pressure. The residue was dissolved with 10 ml of ethanol and specifically ethanol, and the mixture was heated under reflux for 3 h. The reaction was completely checked by TLC.The reaction solution was allowed to cool to room temperature and concentrated under reduced pressure to remove the ethanol.The residue was washed with saturated sodium hydrogencarbonate solution and the aqueous layer was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate overnight, suction filtered and concentrated, and the residue was separated using silica gel column chromatography to give Intermediate 2 as a yellow solid.MS calculated 235, found 236 [M+l].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14916-65-5, 6-Nitropyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; Wuxi Fuqi Pharmaceutical Co., Ltd.; Wang Tao; Wang Binbin; Wang Qinglin; Sun Yilin; You Benjia; Cao Na; (9 pag.)CN107573364; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem