Category: 15069-92-8

Application of 15069-92-8, Adding some certain compound to certain chemical reactions, such as: 15069-92-8, name is 5-Hydroxypicolinic acid,molecular formula is C6H5NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15069-92-8.

5-Hydroxypyridine-2-carboxylic acid (1.50 g) was dissolved in a mixed solvent of tetrahydrofuran (7.5 mL)/N,N-dimethylformamide (7.5 mL), tert-butylamine (1.7 mL), 1-hydroxybenzotriazole (2.20 g), triethylamine (4.5 mL) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (3.10 g) were successively added, and the mixture was stirred at room temperature for 24 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was separated and purified by silica gel column chromatography (hexane:ethyl acetate=33:67?0:100?ethyl acetate_methanol=95:5) to give the title compound (1.05 g) as an orange oil. 1H-NMR (CDCl3) delta: 1.49 (9H, s), 7.23 (1H, dd, J = 2.6 Hz, 8.6 Hz), 7.90-8.01 (2H, m), 8.17 (1H, d, J = 2.6 Hz), 8.57 (1H, br s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15069-92-8, 5-Hydroxypicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2103620; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 15069-92-8, Adding some certain compound to certain chemical reactions, such as: 15069-92-8, name is 5-Hydroxypicolinic acid,molecular formula is C6H5NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15069-92-8.

5-Hydroxypyridine-2-carboxylic acid (1.50 g) was dissolved in a mixed solvent of tetrahydrofuran (7.5 mL)/N,N-dimethylformamide (7.5 mL), tert-butylamine (1.7 mL), 1-hydroxybenzotriazole (2.20 g), triethylamine (4.5 mL) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (3.10 g) were successively added, and the mixture was stirred at room temperature for 24 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was separated and purified by silica gel column chromatography (hexane:ethyl acetate=33:67?0:100?ethyl acetate_methanol=95:5) to give the title compound (1.05 g) as an orange oil. 1H-NMR (CDCl3) delta: 1.49 (9H, s), 7.23 (1H, dd, J = 2.6 Hz, 8.6 Hz), 7.90-8.01 (2H, m), 8.17 (1H, d, J = 2.6 Hz), 8.57 (1H, br s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15069-92-8, 5-Hydroxypicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2103620; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 15069-92-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15069-92-8, name is 5-Hydroxypicolinic acid, molecular formula is C6H5NO3, molecular weight is 139.1088, as common compound, the synthetic route is as follows.

EXAMPLE I-24 Preparation of 2-amino-5-pyridinol By substituting 139.0 g of 5-hydroxypicolinic acid for the 4-hydroxypicolinic acid in example 1 (a), (b) and (c), there is obtained 2-amino-5-pyridinol, as a colorless, granular solid.

Statistics shows that 15069-92-8 is playing an increasingly important role. we look forward to future research findings about 5-Hydroxypicolinic acid.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4022897; (1977); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 15069-92-8, Adding some certain compound to certain chemical reactions, such as: 15069-92-8, name is 5-Hydroxypicolinic acid,molecular formula is C6H5NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15069-92-8.

A mixture of 5-hydroxypicolinic acid (10.0 g, 71.9 mmol), silver carbonate (79 g, 288.0 mmol), and methyl iodide (18.0 ml, 288.0 mmol) in acetonitrile (350 ml) was stirred at rt for 24 hours. Solids were removed through vacuum filtration and washed with ethyl acetate (3 x 80 ml). Filtrate was reconcentrated in vacuo, and the residue was purified by flash chromatography on silica gel using ethyl acetate and hexanes to afford the title compound as a light brown solid (7.2 g, 60% yield). ?H NMR is consistent with ?H NMR of commercially available 5-methoxypyridine-2-carboxylic acid methyl ester.

According to the analysis of related databases, 15069-92-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Koay, Natalie; Tonelli, Devin L.; Truong, Vouy Linh; Tetrahedron Letters; vol. 52; 1; (2011); p. 122 – 124;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem