Category: 151213-42-2

Adding a certain compound to certain chemical reactions, such as: 151213-42-2, (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine, blongs to pyridine-derivatives compound. Quality Control of (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine

Compound II (1.26g, 10mmol) and triethylamine (3.04g, 30mmol) was dissolved in 10mL of dry DMF, under stirring and cooling in an ice-water bath, slowly dropwise added triphenylmethyl chloride (TrCl; 3.07g, 11mmol) and 10mL dry DMF solution prepared. After completion of the dropwise addition, the resulting reaction mixture was stirred at room temperature for 3 hours, TLC showed the reaction was complete. The reaction mixture was poured into 120mL ice water, CH2Cl2 (50mL ¡Á 3) the combined extracts were combined, washed with brine, dried over anhydrous sodium sulfate. The desiccant was removed by suction, and the filtrate was evaporated to dryness on a rotary evaporator, the residue obtained was purified by chromatography using a column to give compound III, as a white solid,

The synthetic route of 151213-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Foshan Saivs Pharmaceutical Technology Co., Ltd.; Cai, Ziyang; (7 pag.)CN104557928; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

151213-42-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151213-42-2, name is (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 6-chloro-4-cyclopropyl-7-fluoro-1-oxo-1,4-dihydronaphthalene-2-carboxylic acid 1a (1 g, 3.5 mmol) with N-ethylpiperazine 2c (0.6 g, 5.25mmol) was loaded in a small flask fitted with a micro condenser, placed in the microwave reactor and irradiated for 25 min at 150C under solvent free conditions. The reaction progress was monitored by TLC. Upon completion of the process, addition of hot absolute ethanol (10 mL) to the reaction mixture was followed by filtration. The filtrate was concentrated and stored at room temperature for precipitation. The solid was filtered off and recrystallized from absolute ethanol to give compound 3c.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 151213-42-2, (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine.

Reference:
Article; Mirzaie; Lari; Vahedi; Hakimi; Russian Journal of General Chemistry; vol. 86; 12; (2016); p. 2865 – 2869; Zh. Obshch. Khim.; vol. 86; 12; (2016); p. 2865 – 2869,5;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The common heterocyclic compound, 151213-42-2, name is (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine, molecular formula is C7H14N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 151213-42-2

General procedure: A mixture of 6-chloro-4-cyclopropyl-7-fluoro-1-oxo-1,4-dihydronaphthalene-2-carboxylic acid 1a (1 g, 3.5 mmol) with N-ethylpiperazine 2c (0.6 g, 5.25mmol) was loaded in a small flask fitted with a micro condenser, placed in the microwave reactor and irradiated for 25 min at 150C under solvent free conditions. The reaction progress was monitored by TLC. Upon completion of the process, addition of hot absolute ethanol (10 mL) to the reaction mixture was followed by filtration. The filtrate was concentrated and stored at room temperature for precipitation. The solid was filtered off and recrystallized from absolute ethanol to give compound 3c.

The synthetic route of 151213-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mirzaie; Lari; Vahedi; Hakimi; Russian Journal of General Chemistry; vol. 86; 12; (2016); p. 2865 – 2869; Zh. Obshch. Khim.; vol. 86; 12; (2016); p. 2865 – 2869,5;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem