Category: 1513-66-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1513-66-2, name is 2,3-Difluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H3F2N

12.8 g of 2-chloro-3-aminopyridine was suspended in 120 mL of 60% aqueous hexafluorophosphoric acid, and 9.0 g sodium nitrite was added little by little thereto at 0C to precipitate crystals. The crystals were collected by filtration and washed with diethyl ether to give 15.75 g diazonium salt. Subsequently, the diazonium salt was suspended in 100 mL xylene and heated at 85C for 3 hours, 28 mL triethylamine was added thereto, and the reaction mixture was diluted with an aqueous saturated sodium bicarbonatesolution and then extracted with ethyl acetate. The extract was washed with brine, and the organic layer was dried over anhydrous sodium sulfate and then filtered through silica gel. The ethyl acetate was removed, and to the resulting xylene solution was added 6.0 mL 2-aminoethanol, and the mixture was heated at 130C for 10 hours. Then, the same procedure as in Production Example 231 was carried out, whereby 385 mg of the title compound (yellowoil) was obtained as a mixture.1H-NMR (CDCl3) delta: 3.60-3.68(m, 2H), 3.84(t, J=4.8Hz, 2H), 6.52-6.60(m, 1H), 7.12-7.20(m, 1H), 7.80-7.85(m, 1H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1513-66-2, 2,3-Difluoropyridine.

Reference:
Patent; Eisai Co., Ltd.; EP1382603; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1513-66-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1513-66-2, name is 2,3-Difluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 18 A mixture of A17 (60 mg, 0.10 mmol), 2,3 -difluoropyri dine (24 mg, 0.21 mmol) and Cs2C03 (101 mg, 0.308 mmol) in DMSO (1 mL) was stirred at 65C for 2 h. The mixture was diluted with water (30 mL) and extracted with EtOAc (3 x 25 mL). The combined organic layers were dried over Na2S04 and filtered to afford the crude product of A18, which was used in the next step directly without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1513-66-2, 2,3-Difluoropyridine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn, P.; CUMMING, Jared, N.; DAI, Xing; (84 pag.)WO2017/139210; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1513-66-2 ,Some common heterocyclic compound, 1513-66-2, molecular formula is C5H3F2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

500 g of DMF was added to a 1000 mL four-necked flask, 100 g of compound A was charged,113.6 g of potassium carbonate and 5 g of tetrabutylammonium bromide, the temperature was raised to 60 C, and 92.6 g of the product was added dropwise2,3-difluoropyridine in 50 g of DMF in a mixed solution at a controlled temperature of 65 to 70 C,The reaction is about 2 hours, the reaction is completed, added to 1000 g of water, the pH is adjusted to 7 to 8 with hydrochloric acid,Stirring for 1 hour, filtering, solid is the etherification (compound I), drying.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1513-66-2, 2,3-Difluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Fuding Chemical Co., Ltd.; Liu Dongwei; Cheng Lizhong; Chang Qing; Dong Hailong; Zhu Ruiyu; Gu Junkun; (16 pag.)CN106632045; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1513-66-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1513-66-2, name is 2,3-Difluoropyridine, molecular formula is C5H3F2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 4-cyano-piperidine-1-carboxylic acid tert-butyl ester (200 mg, 0.95 mmol) in DMF (2 mL) was added to a stirred solution of KHMDS (0.5 M in hexane, 1.9 mmol). After 5 min, a solution of 2,3-difluoropyridine (0.13 g, 1.14 mmol) in DMF (2 mL) was added and stirred for additional 2 h under nitrogen atmosphere. DMF was evaporated in vacuo. The resulting crude product was extracted with EtOAc and the extracts were successively washed with water and brine, and the organic layer was evaporated and subjected to column chromatography (50% Ethyl acetate/hexane) to provide the title Compound. 1H NMR (d6-DMSO, 300 MHz) delta 1.40 (m, 9H), 2.18 (m, 4H), 3.20 (m, 2H), 4.15 (m, 2H), 7.28 (m, 1H), 7.42 (m, 1H), 8.34 (m, 1H); MS (ESI) m/z=307 (MH+).

According to the analysis of related databases, 1513-66-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Genelabs Technologies, Inc.; US2010/204265; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem