Category: 152126-31-3

Reference of 152126-31-3, Adding some certain compound to certain chemical reactions, such as: 152126-31-3, name is 3-Fluoropicolinic acid,molecular formula is C6H4FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152126-31-3.

To 3-fluoro-2-pyridinecarboxylic acid (available from Fluorochem, 63mg, 0.44mmol) was added O-(7-azabenzotriazol-1-yl)-1 ,1 ,3,3-tetramethyluronium hexafluorophosphate (172mg, 0.45mmol), DIPEA (0.106ml) and DMF (1 ml). The reaction was stirred for 20mins at 250C. 6-(1 H-indol-4-yl)-1 H-indazol-4-amine (50mg, 0.20mmol) was added and the reaction was stirred for a further 2Oh at 250C. The solvent was dried under a stream of nitrogen to give the crude product. This sample in DMF was loaded onto an aminopropyl cartridge (5g) and after standing for 3h, the column was washed with 10% methanol in dichloromethane. The appropriate fractions were combined and dried under a stream of nitrogen to give the crude product which was purified by Mass Directed Automated Preparative HPLC (Method B). The solvent was dried under a stream of nitrogen to give the title compound (23mg). LCMS (Method B) R1 = 0.94mins, MH+ = 372

According to the analysis of related databases, 152126-31-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/147190; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 152126-31-3, name is 3-Fluoropicolinic acid, molecular formula is C6H4FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H4FNO2

General method for Examples 43-48Carboxylic acid (0.266 mmol), DMF (0.5 ml.) and DIPEA (0.084 ml.) were added to a Greenhouse Plus tube. HATU (101 mg) in DMF (1 ml.) was added and the reaction was stirred for 1 h. Methyl 5-(4-aminophenyl)-3-[[(frans-4-methylcyclohexyl)carbonyl](1- methylethyl)amino]-2-thiophenecarboxylate (100 mg, a synthesis of which is described as Intermediate 9) in DMF (1 ml.) was then added and the reaction was stirred at room temperature for 24 h. The solvent was evaporated in vacuo using a Genevac vacuum centrifuge. To the residue was added THF (1 ml_), MeOH (1 ml.) and 2M lithium hydroxide solution (1 ml_). The reaction was stirred for 24 h and was then neutralised with 2N HCI (1 ml_). The mixture was partitioned between EtOAc and water and the organic phases were separated and dried using a hydrophobic frit. The organic phases were evaporated in vacuo using a Genevac vacuum centrifuge and the crude material was purified by MDAP HPLC to give the title compound-Example 435-(4-{[(3-Fluoro-2-pyridinyl)carbonyl]amino}phenyl)-3-[[(frans-4- methylcyclohexyl)carbonyl](1 -methylethyl)amino]-2-thiophenecarboxylic acidMS calcd for (C28H30FN3O4S + H)+: 524MS found (electrospray): (M+H)+ = 5241H NMR (de-DMSO): delta 10.81 (1 H, s), 8.59 (1 H, s), 8.00-7.68 (6H, m), 7.43 (1 H, s), 4.73 (1 H, quintet), 2.01 (1 H, t), 1.70-1.39 (5H, m), 1.31-1.10 (5H, m), 0.90 (3H, d), 0.73 (3H, d), 0.71-0.48 (2H, m), 1 exchangeable proton not seen.

With the rapid development of chemical substances, we look forward to future research findings about 152126-31-3.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/59042; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem