Category: 153034-88-9

Synthetic Route of 153034-88-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 2-chloro-4-iodo-3-methyl-pyridine (1.25 g, 4.88 mmol), acetic anhydride (2.31 mL, 24.5 mmol), lithium chloride (1.03 g, 24.2 mmol), Pd2(dba)3 (90 mg, 0.1 mmol), Hnig’s base (1.71 mL, 9.8 mmol) in DMF is heated at 160 0C in the microwave for 20 min. The reaction is partitioned between EtOAc and saturated NaHCOs(aq). The organics layer was collected and washed with brine, dried over Na2SO4 and stripped down in vacuo. The crude product is purified by silica column chromatography eluting with 20% EtOAc: Hexanes giving l-(2-chloro-3-methyl-pyridin-4-yl)-ethanone (408 mg, 2.41 mmol) as a clear oil. 1H NMR (400 MHz, CDCl3) delta 2.46 (s, 3H), 2.59 (s, 3H), 7.28 (d, IH), 8.36 (d, IH); MS m/z 170.2 (M + 1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; NOVARTIS AG; WO2008/79933; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 153034-88-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 15-1. 4-Iodo-N,N,3-trimethylpyridine-2-amine (Compound 15b) A DMF (7.9 mL) solution of 2-chloro-4-iodo-3-methylpyridine (Compound 15a, 500 mg, 1.97 mmol), N-ethyl-N-propan-2-ylpropane-2-amine (0.515 mL, 2.96 mmol), and a THF solution (2.96 mL, 5.92 mmol) of 2M dimethylamine was stirred at 130 C. for 17 h., then the solution was cooled to room temperature and formic acid (0.4 mL) was added. The solution was purified by reversed-phase chromatography (acetonitrile/water, 0.1% formic acid) to obtain the titled Compound 15b (258 mg, yield 50%) as a light brown solution.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; YOSHINO, Hitoshi; TSUCHIYA, Satoshi; MATSUO, Atsushi; SATO, Tsutomu; NISHIMOTO, Masahiro; OGURI, Kyoko; OGAWA, Hiroko; NISHIMURA, Yoshikazu; FURUTA, Yoshiyuki; KASHIWAGI, Hirotaka; HORI, Nobuyuki; KAMON, Takuma; SHIRAISHI, Takuya; YOSHIDA, Shoshin; KAWAI, Takahiro; TANIDA, Satoshi; AOKI, Masahide; (169 pag.)US2019/225604; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 153034-88-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 2-chloro-4-iodo-3-methyl-pyridine (1.25 g, 4.88 mmol), acetic anhydride (2.31 mL, 24.5 mmol), lithium chloride (1.03 g, 24.2 mmol), Pd2(dba)3 (90 mg, 0.1 mmol), Hnig’s base (1.71 mL, 9.8 mmol) in DMF is heated at 160 0C in the microwave for 20 min. The reaction is partitioned between EtOAc and saturated NaHCOs(aq). The organics layer was collected and washed with brine, dried over Na2SO4 and stripped down in vacuo. The crude product is purified by silica column chromatography eluting with 20% EtOAc: Hexanes giving l-(2-chloro-3-methyl-pyridin-4-yl)-ethanone (408 mg, 2.41 mmol) as a clear oil. 1H NMR (400 MHz, CDCl3) delta 2.46 (s, 3H), 2.59 (s, 3H), 7.28 (d, IH), 8.36 (d, IH); MS m/z 170.2 (M + 1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; NOVARTIS AG; WO2008/79933; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 153034-88-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 15-1. 4-Iodo-N,N,3-trimethylpyridine-2-amine (Compound 15b) A DMF (7.9 mL) solution of 2-chloro-4-iodo-3-methylpyridine (Compound 15a, 500 mg, 1.97 mmol), N-ethyl-N-propan-2-ylpropane-2-amine (0.515 mL, 2.96 mmol), and a THF solution (2.96 mL, 5.92 mmol) of 2M dimethylamine was stirred at 130 C. for 17 h., then the solution was cooled to room temperature and formic acid (0.4 mL) was added. The solution was purified by reversed-phase chromatography (acetonitrile/water, 0.1% formic acid) to obtain the titled Compound 15b (258 mg, yield 50%) as a light brown solution.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; YOSHINO, Hitoshi; TSUCHIYA, Satoshi; MATSUO, Atsushi; SATO, Tsutomu; NISHIMOTO, Masahiro; OGURI, Kyoko; OGAWA, Hiroko; NISHIMURA, Yoshikazu; FURUTA, Yoshiyuki; KASHIWAGI, Hirotaka; HORI, Nobuyuki; KAMON, Takuma; SHIRAISHI, Takuya; YOSHIDA, Shoshin; KAWAI, Takahiro; TANIDA, Satoshi; AOKI, Masahide; (169 pag.)US2019/225604; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 153034-88-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 2-chloro-4-iodo-3-methyl-pyridine (1.25 g, 4.88 mmol), acetic anhydride (2.31 mL, 24.5 mmol), lithium chloride (1.03 g, 24.2 mmol), Pd2(dba)3 (90 mg, 0.1 mmol), Hnig’s base (1.71 mL, 9.8 mmol) in DMF is heated at 160 0C in the microwave for 20 min. The reaction is partitioned between EtOAc and saturated NaHCOs(aq). The organics layer was collected and washed with brine, dried over Na2SO4 and stripped down in vacuo. The crude product is purified by silica column chromatography eluting with 20% EtOAc: Hexanes giving l-(2-chloro-3-methyl-pyridin-4-yl)-ethanone (408 mg, 2.41 mmol) as a clear oil. 1H NMR (400 MHz, CDCl3) delta 2.46 (s, 3H), 2.59 (s, 3H), 7.28 (d, IH), 8.36 (d, IH); MS m/z 170.2 (M + 1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; NOVARTIS AG; WO2008/79933; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 153034-88-9, Adding some certain compound to certain chemical reactions, such as: 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine,molecular formula is C6H5ClIN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 153034-88-9.

A mixture of 2-chloro-4-iodo-3-methylpyridine (250 mg, 986 mumol) (AstaTech, catNo.22441) and boric acid, trimethyl ester (224 muL, 1.97 mmol) in tetrahydrofuran (5.0 mL) was added 2.5 M n-butyllithium in hexanes (789 muL, 1.97 mmol) dropwise at -78 C. The reaction mixture was allowed to warm up to r.t. after 90 min and stirred for another 30 min. The resulting mixture was concentrated and acetonitrile (5 mL) was added. The resulting suspension was filtered through celite then concentrated to give the desired product. LCMS calculated for C6H8BClNO2 (M+H)+: m/z=172.2; found 172.2

According to the analysis of related databases, 153034-88-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Incyte Corporation; Li, Zhenwu; Wu, Liangxing; Yao, Wenqing; (48 pag.)US2017/320875; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

The mixture of 234 mg of 2-chloro-4-iodo picoline, 17.6 mg of copper iodide, 33.3 mg of 1,10-phenanthroline, 601 mg of cesium carbonate, 230 muL of 4-methoxybenzyl alcohol, and 0.5 mL of toluene, was stirred at 110C for 4 hours. After adding water and a saturated aqueous solution of sodium hydrogen carbonate, the mixture was extracted with chloroform, and the organic layer was washed with saturated brine. The thus-obtained organic layer was dried over anhydrous sodium sulfate, insolubles were filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by preparative thin-layer chromatography, and 207 mg of 2-chloro-4-[(4-methoxybenzyl)oxy]-3-methylpyridine [64-1] as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1790650; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 153034-88-9 ,Some common heterocyclic compound, 153034-88-9, molecular formula is C6H5ClIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-chloro-4-iodo-3-methylpyridine (303 mg, 1.20 mmol) (Aldrich, catNo.724092), phenylboronic acid (160 mg, 1.32 mmol) (Aldrich, catNo.78181) and sodium carbonate (317 mg, 2.99 mmol) in tert-butyl alcohol (10 mL) and water (6 mL) was added Pd-127 (181 mg, 0.239 mmol). The resulting mixture was purged with N2, and then heated at 80 C. for 2 h. The reaction mixture was diluted with methylene chloride, washed with saturated NaHCO3, water and brine. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on a silica gel column eluting with 10 to 20% ethyl acetate in hexanes to give the desired product (225 mg, 92%). LCMS calculated for C12H11ClN (M+H)+: m/z=204.2; found 204.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Incyte Corporation; Li, Zhenwu; Wu, Liangxing; Yao, Wenqing; (48 pag.)US2017/320875; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 153034-88-9 ,Some common heterocyclic compound, 153034-88-9, molecular formula is C6H5ClIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-chloro-4-iodo-3-methylpyridine (303 mg, 1.20 mmol) (Aldrich, catNo.724092), phenylboronic acid (160 mg, 1.32 mmol) (Aldrich, catNo.78181) and sodium carbonate (317 mg, 2.99 mmol) in tert-butyl alcohol (10 mL) and water (6 mL) was added Pd-127 (181 mg, 0.239 mmol). The resulting mixture was purged with N2, and then heated at 80 C. for 2 h. The reaction mixture was diluted with methylene chloride, washed with saturated NaHCO3, water and brine. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on a silica gel column eluting with 10 to 20% ethyl acetate in hexanes to give the desired product (225 mg, 92%). LCMS calculated for C12H11ClN (M+H)+: m/z=204.2; found 204.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Incyte Corporation; Li, Zhenwu; Wu, Liangxing; Yao, Wenqing; (48 pag.)US2017/320875; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine, molecular formula is C6H5ClIN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 153034-88-9

General procedure: Table 2, example 4 PdOAc2 (3.4 mg, 0.015 mmol), cesium carbonate (293 mg, 0.900 mmol), and tris(4-methoxyphenyl)phosphine (12 mg, 0.033 mmol) were combined in dioxane (2 mL) and stirred for 15 min at room temperature under an atmosphere of nitrogen. Then 6-chloro-3-iodo-2-methylpyridine (76 mg, 0.30 mmol), O-benzoyl morpholine (69 mg, 0.330 mmol), methylboronic acid(20 mg, 0.33 mmol), and bicyclo[2.2.1]hept-2-ene (28 mg,0.30 mmol) were added as a solution in dioxane (2 mL) to the previously prepared solution of catalyst and base. The reaction was sealed and heated to 100C for 18 h. The reaction mixturewas cooled to room temperature and filtered through a pad of celite eluting with ethyl acetate. The eluent was concentrated and the residue was puried by silica gel chromatography (ISCO 24 gsilica cartridge; 0-30% ethyl acetate in hexanes) to provide4-(6-chloro-2,3-dimethylpyridin-4-yl)morpholine (41 mg, 60%yield) as a colorless oil

With the rapid development of chemical substances, we look forward to future research findings about 153034-88-9.

Reference:
Article; Wilson, Jonathan E.; Tetrahedron Letters; vol. 57; 46; (2016); p. 5053 – 5056;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem