Synthetic Route of 1531-18-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1531-18-6, name is 2-Ethylisonicotinonitrile, molecular formula is C8H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Weigh 2.32 g of 2-ethyl-4-cyanopyridine and 0.06 g of ETS-10 in a reaction tube.Add 50mL of water, heat up to 110 C reaction, TLC tracking detection,The reaction was completed in 24 hours, and after cooling, it was centrifuged.The resulting solution is distilled off to obtain a product2-ethyl-4-pyridinecarboxamide 1.45 g, yield 97%,The purity was 99.72% (gas chromatography detection). Centrifuging the resulting solid for repeated reaction,The reaction conditions and the amount of raw materials are the same as above, and when repeated 5 times,The yield is 92% or more, and the yield is 90% in the fifth reaction.The purity is 98% or more.
According to the analysis of related databases, 1531-18-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wenzhou University; Xiong Jing; Hu Rongrong; Liu Wuqiang; Tao Yangyang; Feng Xiaogang; Zhou Zheng; (6 pag.)CN104072409; (2016); B;,
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