Category: 1539-42-0

The author of 《In Vivo Chemoselective Photoacoustic Imaging of Copper(II) in Plant and Animal Subjects》 were Zeng, Leli; Ma, Gongcheng; Xu, Han; Mu, Jing; Li, Fan; Gao, Xiaoting; Deng, Zhuoting; Qu, Junle; Huang, Peng; Lin, Jing. And the article was published in Small in 2019. Name: Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

The detection of Cu2+ in living plants and animals is of great importance for environment monitoring and disease diagnosis. Here, a near-IR (NIR) turn-on photoacoustic (PA) probe (denoted as LET-2) is developed for Cu2+ detection in living subjects, such as soybean sprouts and mice. The absorbance band of LET-2 shifts from 625 to 715 nm after the interaction with Cu2+, thus producing strong PA signal output at 715 nm (PA715) as an indicator. The PA715 value is increased as a function of the concentration of Cu2+ (0 × 10-6-20 × 10-6M), with a calculated limit of detection of 10.8 × 10-9M. More importantly, both in vitro and in vivo studies in soybean sprouts and mice indicate that the as-prepared LET-2 PA probe is highly sensitive and selective for Cu2+ detection. These findings provide a solution for in vivo detection of metal ions by using chemoselective PA probes. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Name: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Name: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Molecules included an article by Fang, Mingxi; Xia, Shuai; Bi, Jianheng; Wigstrom, Travis P.; Valenzano, Loredana; Wang, Jianbo; Tanasova, Marina; Luck, Rudy L.; Liu, Haiying. Electric Literature of C12H13N3. The article was titled 《Detecting Zn(II) ions in live cells with near-infrared fluorescent probes》. The information in the text is summarized as follows:

Two near-IR fluorescent probes (A and B) containing hemicyanine structures appended to dipicolylamine (DPA), and a dipicolylamine derivative where one pyridine was substituted with pyrazine, resp., were synthesized and tested for the identification of Zn(II) ions in live cells. In both probes, an acetyl group is attached to the phenolic oxygen atom of the hemicyanine platform to decrease the probe fluorescence background. Probe A displays sensitive fluorescence responses and binds preferentially to Zn(II) ions over other metal ions such as Cd2+ ions with a low detection limit of 0.45 nM. In contrast, the emission spectra of probe B is not significantly affected if Zn(II) ions are added. Probe A possesses excellent membrane permeability and low cytotoxicity, allowing for sensitive imaging of both exogenously supplemented Zn(II) ions in live cells, and endogenously releases Zn(II) ions in cells after treatment of 2,2-dithiodipyridine. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Liu, Wenbo; Tao, Ouyang; Chen, Li; Ling, Yun; Zeng, Ming; Jin, Hongguang; Jiang, Dengzhao published an article in RSC Advances. The title of the article was 《Synthesis and characterization of a Cu(II) coordination-containing TAM radical as a nitroxyl probe》.Related Products of 1539-42-0 The author mentioned the following in the article:

Nitroxyl (HNO) has been identified as an important signaling mol. in biol. systems, and it plays critical roles in many physiol. processes. However, its detection remains challenging because of the limited sensitivity and/or specificity of existing detection methods. Low-frequency ESR (EPR) spectroscopy and imaging, coupled with the use of exogenous paramagnetic probes, have been indispensable techniques for the in vivo measurement of various physiol. parameters owing to their specificity, noninvasiveness and good depth of magnetic field penetration in animal tissues. However, the in vivo detection of HNO levels by EPR spectroscopy and imaging is limited due to the need for improved probes. We report the first “”turn on-response”” EPR probe for HNO utilizing a Cu(II) coordination-containing TAM radical (denoted as CuII[TD1]). Upon reaction with HNO, CuII[TD1] shows a 16.1-fold turn-on in EPR signal with a low detection limit of 1.95 μM. Moreover, low-temperature EPR spectroscopic and ESI-MS studies showed that the sensing mechanism relies on the reduction of Cu(II) by HNO. Lastly, CuII[TD1] is selective for HNO over other reactive nitrogen and oxygen species except for some reductants (Cys and Asc). This new Cu(II) coordination-containing TAM radical shows great potential for in vivo EPR HNO applications in the absence of reducing agents and provides insights into developing improved and targeted EPR HNO probes for biomedical applications. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-pot synthesis of 2,2′ -dipicolylamine derived highly photoluminescent nitrogen-doped carbon quantum dots for Fe3+ detection and fingermark detection》 was published in Nanotechnology in 2020. These research results belong to Li, Quan; Guo, Zhiwei; Zhao, Xiaoyan; Zhang, Taoyi; Chen, Jing; Wei, Yun. Related Products of 1539-42-0 The article mentions the following:

The novel nitrogen-doped carbon quantum dots (N-CQDs) with high fluorescence quantum yield of 23.2% were successfully prepared via a simple hydrothermal reaction with citric acid and 2,2′ -dipicolylamine. The as-prepared blue fluorescent N-CQDs had excellent water dispersibility, and showed pH and excitation-dependent emission behaviors. Noticeably, owing to the strong interaction between the residual 2,2′ -dipicolylamine group on the surface of N-CQDs and Fe3+, the N-CQDs could be used as a turn off fluorescence probe for Fe3+ sensing through an electron transfer process. Moreover, the photoluminescent N-CQDs/poly(vinyl alc.) film was further applied for latent fingermark imaging. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Rahman, Fatema; Wushur, Imin; Malla, Nabin; Aastrand, Ove Alexander Hoegmoen; Rongved, Paal; Winberg, Jan-Olof; Sylte, Ingebrigt published an article in Molecules. The title of the article was 《Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases》.Recommanded Product: 1539-42-0 The author mentioned the following in the article:

Inhibition of bacterial virulence is believed to be a new treatment option for bacterial infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris pyridine ethylene diamine (TPED), pyridine and thiophene derivatives as putative inhibitors of the bacterial virulence factors thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) and the human zinc metalloproteases, matrix metalloprotease-9 (MMP-9) and matrix metalloprotease-14 (MMP-14). These compounds have nitrogen or sulfur as putative donor atoms for zinc chelation. In general, the compounds showed stronger inhibition of MMP-14 and PLN than of the other enzymes, with Ki values in the lower μM range. Except for DPA, none of the compounds showed significantly stronger inhibition of the virulence factors than of the human zinc metalloproteases. TPA and Zn230 were the only compounds that inhibited all five zinc metalloproteinases with a Ki value in the lower μM range. The thiophene compounds gave weak or no inhibition. Docking indicated that some of the compounds coordinated zinc by one oxygen atom from a hydroxyl or carbonyl group, or by oxygen atoms both from a hydroxyl group and a carbonyl group, and not by pyridine nitrogen as in DPA and TPA. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wolowicz, Anna; Staszak, Katarzyna; Hubicki, Zbigniew published an article in Molecules. The title of the article was 《Removal of Copper(II) in the Presence of Sodium Dodecylobenzene Sulfonate from Acidic Effluents Using Adsorption on Ion Exchangers and Micellar-Enhanced Ultrafiltration Methods》.Name: Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

The selective removal of Cu(II) in the presence of sodium dodecylobenzene sulfonate from acidic effluents was made using the adsorption and micellar-enhanced ultrafiltration methods. Lewatit MonoPlus TP220 showed the best adsorption behavior in the systems containing Cu(II) in the presence of ABSNa50 surfactant compared to the other adsorbents (removal efficiency ≈ 100%, sorption capacity ≈ 10 mg/g). The kinetics followed the pseudo-second order kinetic equation. The Langmuir adsorption capacities were 110 mg/g (the system with ABSNa50 above CMC) and 130.38 mg/g (the system with ABSNa50 below CMC). The working ion exchange capacities were Cw = 0.0216 g/mL and Cw = 0.0135 g/mL. The copper removal by the micellar-enhanced ultrafiltration method was 76.46% (0.1 mol/L HCl). The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Name: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Name: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Highly efficient removal of Cu(II) by novel dendritic polyamine-pyridine-grafted chitosan beads from complicated salty and acidic wastewaters》 was published in RSC Advances in 2020. These research results belong to Wang, Li-Li; Ling, Chen; Li, Bang-Sen; Zhang, Da-Shuai; Li, Chen; Zhang, Xiao-Peng; Shi, Zai-Feng. Reference of Bis(pyridin-2-ylmethyl)amine The article mentions the following:

In this study, dendritic polyamine chitosan beads with and without 2-aminomethyl pyridine were facilely prepared and characterized. Compared to CN (without the pyridine function), more adsorption active sites, larger pores, higher nitrogen content, higher sp. surface area, and higher strength could be obtained for CNP (with the pyridine function). CNP microspheres afforded a larger adsorption capacity than those obtained by CN for different pH values; further, the uptake amounts of Cu(II) were 0.84 and 1.12 mmol g-1 for CN and CNP beads, resp., at pH 5. The CNP microspheres could scavenge Cu(II) from highly acidic and salty solutions: the maximum simulated uptake amount of 1.93 mmol g-1 at pH 5 could be achieved. Due to the strong bonding ability and weakly basic property of pyridine groups, the adsorption capacity of Cu(II) at pH 1 was 0.75 mmol g-1 in highly salty solutions, which was comparative to those obtained from the com. pyridine chelating resin M4195 (QCu(II) = 0.78 mmol g-1 at pH 1). In addition, a distinct salt-promotion effect could be observed for CNP beads at both pH 5 and 1. Therefore, the prepared adsorbent CNP beads can have promising potential applications in the selective capturing of heavy metals in complex solutions with higher concentrations of H+ and inorganic salts, such as wastewaters from electroplating liquid and battery industries. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C12H13N3In 2021 ,《Electronic effects on polypyridyl Co complex-based water reduction catalysts》 appeared in RSC Advances. The author of the article were Guo, Xusheng; Li, Chao; Wang, Weibo; Zhang, Baowen; Hou, Yuanjun; Wang, Xuesong; Zhou, Qianxiong. The article conveys some information:

Three new isomeric cobalt complexes of TPA (tris(2-pyridylmethyl)amine) based on methoxy substitution at the ortho, meta and para positions, resp., were constructed and their photocatalytic proton reduction efficiencies were compared. It was found that there are good linear correlations with the Hammett constants of the substituents for the computed Co-N bond lengths, redox potentials of CoII/I and CoI/0 events, and the photocatalytic activities of the complexes. The ortho-substituted Co complex distinguished itself from the others remarkably in all these comparisons, demonstrating the presence of a steric effect besides the electronic effect. For other examined complexes, a stronger electron-donating substituent may lead to a higher hydrogen evolution efficiency, suggesting that the formation of a Co(III) hydride intermediate is the rate-limiting step. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Phosphoprotein Detection with a Single Nanofluidic Diode Decorated with Zinc Chelates》 was published in ChemPlusChem in 2020. These research results belong to Nasir, Saima; Ali, Mubarak; Ahmed, Ishtiaq; Niemeyer, Christof M.; Ensinger, Wolfgang. Category: pyridine-derivatives The article mentions the following:

We report a nanofluidic device for the label-free detection of phosphoprotein (PPn) analytes. To achieve this goal, a metal ion chelator, namely 4-[bis(2-pyridylmethyl)aminomethyl]aniline (DPA-NH2) compound was synthesized. Single asym. nanofluidic channels were fabricated in polyethylene terephthalate (PET) membranes. The chelator (DPA-NH2) mols. are subsequently immobilized on the nanochannel surface, followed by the zinc ion complexation to afford DPA-Zn2+ chelates, which act as ligand moieties for the specific binding of phosphoproteins. The success of the chem. reaction and biomol. recognition process that occur in a confined geometry can be monitored from the changes in elec. readout of the nanochannel. The nanofluidic sensor has the ability to sensitively and specifically detect lower concentrations (≥1 nM) of phosphoprotein (albumin and α-casein) in the surrounding environment as evidenced from the significant decrease in ion current flowing through the nanochannels. However, dephosphoproteins such as lysozyme and dephospho-α-casein even at higher concentration (>1μM) could not induce any significant change in the transmembrane ion flux. This observation indicated the sensitivity and specificity of the proposed nanofluidic sensor towards PPn proteins, and has potential for use in differentiating between phosphoproteins and dephosphoproteins. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1539-42-0In 2021 ,《Strategic Evaluation of the Traceless Staudinger Ligation for Radiolabeling with the Tricarbonyl Core》 appeared in Molecules. The author of the article were Mamat, Constantin; Jentschel, Christian; Koeckerling, Martin; Steinbach, Joerg. The article conveys some information:

The traceless Staudinger ligation with its two variants is a powerful biorthogonal conjugation method not only for the connection of biomols., but also for the introduction of fluorescence- or radiolabels under mild reaction conditions. Herein, the strategic evaluation of the traceless Staudinger ligation for radiolabeling 99mTc using the fac-[Tc(CO)3]+ core is presented. A convenient and high-yielding three-step synthetic procedure of dipicolylamine-based phosphanols as ligands for the mild radiolabeling was developed. The labeling was accomplished using a tricarbonyl kit and a 99mTc-pertechnetate generator eluate showing 87% radiochem. conversion. The resp. rhenium-based, non-radioactive reference compounds were synthesized using (Et4N)2[Re(CO)3Br3] as precursor. All products were analyzed by NMR, MS, and elemental anal. Addnl. XRD analyses were performed. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem