Category: 1539-42-0

Application of 1539-42-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1539-42-0, Name is Bis(pyridin-2-ylmethyl)amine, SMILES is C(NCC1=NC=CC=C1)C1=NC=CC=C1, belongs to pyridine-derivatives compound. In a article, author is Tamer, Omer, introduce new discover of the category.

Synthesis of the first mixed ligand Mn (II) and Cd (II) complexes of 4-methoxy-pyridine-2-carboxylic acid, molecular docking studies and investigation of their anti-tumor effects in vitro

The first mixed ligand Mn (II) and Cd (II) complexes containing 4-methoxy-pyridine-2-carboxylic acid (4-mpic) and 4,4 ‘-dimethyl-2,2 ‘-bipyridine (dmbpy) were synthesized in this study. The geometric structures of [Mn(4-mpic)(2)(dmbpy)] (complex 1) and [Cd(4-mpic)(2)(dmbpy)] (complex 2) were determined by single crystal X-Ray diffraction method. FT-IR and UV-Vis spectra were also recorded to investigate vibrational and electronic properties of complexes 1 and 2. Density functional theory (DFT) calculations were also carried out to provide a deep understanding in geometric, spectroscopic, electronic and nonlinear optical (NLO) properties of complexes 1 and 2. The first-order hyperpolarizibility (beta) parameter calculated as 332.9736 x 10(-30) esu demonstrated that complex 1 is an extremely promising candidate to NLO materials. Natural bond orbital (NBO) analysis not only verified the distorted octahedral geometries of central metal ions, but also found out the high-energy interactions responsible for biological activities for complexes 1 and 2. Anti-cancer activities of complexes 1 and 2 were tested on human breast carcinoma cell line MCF-7 (ER and PR positive, HER2 negative) and the triple negative breast carcinoma cell line MDA-MB 231 (ER, PR and HER2 negative). Dose-response relationship derived from MTT assays indicates that complexes 1 and 2 are showing concentration-dependent effects, which could suggest a potential use for these drug combinations in cancer cell lines.

Application of 1539-42-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1539-42-0.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application of 1539-42-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1539-42-0, name is Bis(pyridin-2-ylmethyl)amine, molecular formula is C12H13N3, molecular weight is 199.25, as common compound, the synthetic route is as follows.

1-Chloro-4-iodo-2-trifluoromethylbenzene (10 mmol) obtained in Reaction 1.2 was dissolved in 20 ml of toluene.Bis(pyridyl-2-methyl)amine (12 mmol) was added sequentially to the system.Palladium acetate (0.5 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (12 mmol), 3 ml of triethylamine,After stirring for 10 minutes, 10 ml of an aqueous solution of cesium carbonate (10 mmol) was added, and the mixture was heated to 50 C for 4 hours.After the reaction was completed, 20 ml of water was added to the system, stirred for 20 minutes, and liquid was separated.The organic phase is dried over anhydrous sodium sulfate, concentrated and purified by flash column chromatography.Yielding 3.3 g of yellow 4-chloro-N,N-bis(pyridinyl-2-methyl)-3-trifluoromethylaniline powder,The yield was 87.5%.

The chemical industry reduces the impact on the environment during synthesis 1539-42-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Jingfan; Jing Fan; Ge Baoyin; Zhang Ruwei; Zhai Xuexu; (9 pag.)CN108633898; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1539-42-0, name is Bis(pyridin-2-ylmethyl)amine, the common compound, a new synthetic route is introduced below. Computed Properties of C12H13N3

The synthesis followed a modified literature procedure [35]. Amixture of DPA (4.21 g, 20.68 mmol) and triethylamine (4.18 g,41.3 mmol) was dissolved in THF and added dropwise to a solution of 2,6-bis(chloromethyl)-4-methylphenol (2.12 g, 10.3 mmol) in THF at 0C. After the complete addition of the DPA mixture the solution was warmed up to room temperature and left stirring for 4 days. The triethylamine salt precipitate was removed by filtration and washed 3 times with THF, and the combined filtrates were concentrated under vacuum. The residue was dissolved in 50 ml of water and extracted with CH2Cl2 (3¡Á50 ml). The extracts were combined, dried with MgSO4 and the solvent was removed under vacuum. The product was obtained as a yellow oily residue. Yield: 5.24 g (95.6%). 1H NMR (CDCl3): delta 8.42 (4H, m), 7.68 (m, 4H), 7.53 (dd, J=7.8, 3.2, 4H) 7.22 (m, 4H), 6.92 (d,J=3.2, 2H) 3.79 (d, J=3.3, 8H) 3.71 (d, J=3.2, 4H) 2.19 (d,J=3.3, 3H)

The synthetic route of 1539-42-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bedin, Michele; Agarwala, Hemlata; Marx, Jennifer; Schuenemann, Volker; Ott, Sascha; Thapper, Anders; Inorganica Chimica Acta; vol. 490; (2019); p. 254 – 260;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1539-42-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1539-42-0, name is Bis(pyridin-2-ylmethyl)amine. This compound has unique chemical properties. The synthetic route is as follows.

1-Chloro-4-iodo-2-trifluoromethylbenzene (10 mmol) obtained in Reaction 1.2Dissolved in 20 ml of toluene, bis(pyridyl-2-methyl)amine (12 mmol), palladium acetate (0.5 mmol), 2,2′-bis(diphenylphosphino)-1,1 ‘-Binaphthyl (12 mmol), 3 ml of triethylamine, after stirring for 10 minutes, add 10 ml of an aqueous solution of cesium carbonate (10 mmol), and heat to 50 C for 4 hours. After the reaction, add 20 ml of water to the system. After stirring for 20 minutes, the organic layer was dried over anhydrous sodium sulfate, concentrated, and purified by flash column chromatography Fluoromethylaniline powder, yield 87.5%.

According to the analysis of related databases, 1539-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jingfan; Jing Fan; Ge Baoyin; Zhang Ruwei; (8 pag.)CN108530342; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem