Category: 1539-42-0

《Sensitive Detection of Broad-Spectrum Bacteria with Small-Molecule Fluorescent Excimer Chemosensorsã€?was published in ACS Sensors in 2020. These research results belong to Cabral, Aaron D.; Rafiei, Nafiseh; de Araujo, Elvin D.; Radu, Tudor B.; Toutah, Krimo; Nino, Daniel; Murcar-Evans, Bronte I.; Milstein, Joshua N.; Kraskouskaya, Dziyana; Gunning, Patrick T.. HPLC of Formula: 1539-42-0 The article mentions the following:

Antibiotic resistance is a major problem for world health, triggered by the unnecessary usage of broad-spectrum antibiotics on purportedly infected patients. Current clin. standards require lengthy protocols for the detection of bacterial species in sterile physiol. fluids. A class of small-mol. fluorescent chemosensors termed ProxyPhos is capable of rapid, sensitive, and facile detection of broad-spectrum bacteria. The sensors act via a turn-on fluorescent excimer mechanism, where close-proximity binding of multiple sensor units amplifies a red shift emission signal. ProxyPhos sensors were able to detect down to 10 CFUs of model strains by flow cytometry assays and showed selectivity over mammalian cells in a bacterial coculture through fluorescence microscopy. The studies reveal that the zinc(II)-chelates cyclen and cyclam are novel and effective binding units for the detection of both Gram-neg. and Gram-pos. bacterial strains. Mode of action studies revealed that the chemosensors detect Gram-neg. and Gram-pos. strains with two distinct mechanisms. Preliminary studies applying ProxyPhos sensors to sterile physiol. fluids (cerebrospinal fluid) in flow cytometry assays were successful. The results suggest that ProxyPhos sensors can be developed as a rapid, inexpensive, and robust tool for the “”yes-no”” detection of broad-spectrum bacteria in sterile fluids. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Dalton Transactions included an article by Zhu, Ling; Bai, Yue-Ling; Zhao, Yongmei; Xing, Feifei; Li, Ming-Xing; Zhu, Shourong. Recommanded Product: 1539-42-0. The article was titled 《Bis(2-pyridylmethyl)amine-functionalized alizarin: an efficient and simple colorimetric sensor for fluoride and a fluorescence turn-on sensor for Al3+ in an organic solutionã€? The information in the text is summarized as follows:

A complexone analog chemosensor, H2L, bearing chelating bis(2-pyridylmethyl) amine and alizarin groups was synthesized via the Mannich reaction. H2L chromically responds to OH-, F-, CH3COO-, and H2PO4- in DMF, CH3CN, and acetone, but not in CH3OH or H2O. The addition of F- ions to H2L selectively induces a significant and visible color change in acetonitrile and shifts both methylene proton signals upfield. H2L also exhibits visible responses to Mg2+, Sr2+, Ba2+, Tb3+, Cu2+, Co2+, Ni2+, Zn2+, Mn2+, Cd2+, and Fe3+ in solution AlCl3 can form an Al : L = 2 : 3 complex that not only changes the color of the DMF solution, but also significantly increases its fluorescence intensity. The limit of fluorescence turn-on detection for AlCl3 in DMF is 2.7 × 10-8 M, which is an order higher than those of other anthraquinone sensors reported in the literature. NMR spectroscopy shows that hydroxyl is not deprotonated upon interacting with Al3+, but will be partially deprotonated in the presence of Zn2+. Contrary to the complexone, the H2L-Ce(III) complex does not react chromically to F-. However, the H2L-NiCl2 complex responds chromically to F-, with higher sensitivity (LOD = 1.3 × 10-6 M F- in acetonitrile) than free H2L. The spectral changes in the presence of F- are similar to that of OH-; however, the spectrum shifts slightly to a longer wavelength and is more sensitive to both H2L and the H2L-NiCl2 complex. Moreover, 4% or less H2O in the solvent essentially has no influence on the F- sensitivity; however, high water content significantly decreases the F- sensitivity. The spectral changes of the Zn2+, Cu2+, Fe3+, Ce3+, and Ni2+ complexes in the presence of different NaOH concentrations were also investigated. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2019 ,《Ruthenium(II)-Polypyridyl-Based Sensor Bearing a DPA Unit for Selective Detection of Cu(II) Ion in Aqueous Medium》 was published in ChemistrySelect. The article was written by Arora, Aayushi; Kaushal, Jolly; Kumar, Arun; Kumar, Pramod; Kumar, Sushil. The article contains the following contents:

Ruthenium(II) polypyridyl linked di-(2-picolyl)amine (DPA) based chemosensor [Ru(bpy)2(bpmpip)](PF6)2 (Ru-L) has been developed for the selective detection of Cu(II) ion in purely aqueous medium. The change in absorbance and emission spectra of chemosensor Ru-L was observable upon addition of Cu2+ ion. Competitive binding studies, detection limit (18.9 nM) and binding constants illustrate significant sensing ability of chemosensor Ru-L. Spectral behavior of chemosensor Ru-L at different pH was also investigated in absence and presence of Cu2+ ion. Binding of Cu2+ to Ru-L occurs in 1:1 stoichiometry, in good agreement with the results obatined from ESI-mass spectrometry, Job’s plot experiment and spectroscopic titrations The emission intensity of Ru-L was selectively quenched by Cu2+ ion and an obvious color change from red orange to yellow in aqueous solution as well as on paper strips was observed under UV light. The reversibility cycles for the detection of Cu2+ ion were achieved by EDTA and corresponding logic gate was also developed. The water solubility, reversibility and optical visualization of the present chemosensor make it ideal for practical applications on real samples. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 1539-42-0In 2020 ,《A red-emitting luminescent probe for sequentially detecting Cu2+ and cysteine/histidine in aqueous solution and its imaging application in living zebrafish》 appeared in Dyes and Pigments. The author of the article were Yang, Yutong; Li, Yibin; Zhi, Xiaomin; Xu, Yingjun; Li, Minna. The article conveys some information:

A unique red-emissive luminescent probe based on dipicolyl amine (DPA) tethered ruthenium(II) tris(bipyridine) derivative (Ru-DPA) has been developed for the sequential and specific detection of Cu2+ and cysteine (Cys)/histidine (His) in pure aqueous medium. The probe Ru-DPA displayed an ′on-off′ luminescence response at 610 nm specifically toward Cu2+, accompanied by a distinct naked-eye luminescence color change from orange-red to colorless. Also, Ru-DPA enabled anal. of Cu2+ with a detection of limit as low as 0.04 μM. Addnl., the in situ generated Ru-DPA-Cu ensemble detected specifically Cys/His based on the strong affinity for Cu2+ to Cys and His, giving rise to a significant increase in the MLCT-based luminescence of Ru(II) complex and a relevant chromogenic change from colorless to orange-red. This copper (II) ion competitive-displacement detection strategy offered a good linearity with a low detection limit for Cys at 0.24 μM and His at 1.4 μM under pure aqueous medium. Moreover, Ru-DPA exhibited extremely low cytotoxicity (>90% viability at a concentration range from 20 to 100 μM), excellent membrane permeability and was successfully applied to the luminescence imaging of Cu2+ and Cys/His both in living bone mesenchymal stem cells (BMSCs) and zebrafish. The results demonstrated the great potential of Ru-DPA for monitoring Cu2+ and Cys/His in environmental and biol. systems. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《Two telomerase-targeting Pt(II) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells》 appeared in Dalton Transactions. The author of the article were Qin, Qi-Pin; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Luo, Zhi-Hui; Wang, Shu-Long; Zou, Bi-Qun; Liang, Hong. The article conveys some information:

Two novel Pt(IIi) complexes, [Pt(B-TFA)Cl]Cl (Pt1) and [Pt(J-TFA)Cl]Cl (Pt2) with jatrorrhizine and berberine derivatives (B-TFA and J-TFA) were first prepared as desirable luminescent agents for cellular applications and potent telomerase inhibitors, which can induce bladder T-24 tumor cell apoptosis by targeting telomerase, together with induction of mitochondrial dysfunction, telomere DNA damage and cell-cycle arrest. Importantly, T-24 tumor inhibition rate (TIR) was 50.4% for Pt2, which was higher than that of Pt1 (26.4%) and cisplatin (37.1%). Taken together, all the results indicated that jatrorrhizine and berberine derivatives Pt1 and Pt2 show low toxicity and could be novel Pt-based anti-cancer drug candidates. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Quality Control of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Quality Control of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma》 was published in Bioorganic Chemistry in 2020. These research results belong to Khan, Saman; Zafar, Atif; Naseem, Imrana. Product Details of 1539-42-0 The article mentions the following:

Targeted therapy is a new strategy for cancer treatment that targets chem. entities specific to cancer cells than normal ones. One of the features associated with malignancy is the elevated copper which plays an integral role in angiogenesis. Work is in progress in our lab to identify new copper chelators to target elevated copper under targeted therapy for the killing of cancer cells. Recently, a coumarin-based copper chelator, di(2-picolyl)amine-3(bromoacetyl)coumarin hybrid mol. (ligand-L) has been synthesized by us, and also studied its copper-dependent macromol. damage response in copper overloaded lymphocytes. The present study investigates the anticancer activity of ligand-L and its mode of action in rat model of diethylnitrosamine (DEN) induced hepatocellular carcinoma. It has been found that liver tissue has a marked increase in copper levels in DEN induced hepatocellular carcinoma. Ex vivo results showed that ligand-L inhibited cell viability, induced reactive oxygen species (ROS) generation, DNA damage, loss of mitochondrial membrane potential and caspase-3 activation in isolated hepatocellular carcinoma cells (HCC). All these effects induced by ligand-L were abrogated by neocuproine and N-acetylcysteine (ROS scavenger). Further, ligand-L treatment of animals bearing hepatocellular carcinoma results in an increment in the cellular redox scavengers, lipid peroxidation and DNA breakage in malignant hepatocytes. In vivo studies using ligand-L also showed that ligand-L possesses anticancer properties as evidenced by improvement in liver marker enzymes and liver surface morphol., and reduced alpha-fetoprotein in the treated group compared to untreated cancer-induced group. Overall, this study suggests that copper-ligand-L interaction leads to ROS generation which caused DNA damage and apoptosis in malignant cells. This study provides enough support to establish ligand-L as a clin. relevant lead mol. for the treatment of different malignancies. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Bis(zinc(II)-dipicolylamine)-functionalized sub-2 μm core-shell microspheres for the analysis of N-phosphoproteome》 was published in Nature Communications in 2020. These research results belong to Hu, Yechen; Jiang, Bo; Weng, Yejing; Sui, Zhigang; Zhao, Baofeng; Chen, Yuanbo; Liu, Lukuan; Wu, Qiong; Liang, Zhen; Zhang, Lihua; Zhang, Yukui. Product Details of 1539-42-0 The article mentions the following:

Protein N-phosphorylation plays a critical role in central metabolism and two/multicomponent signaling of prokaryotes. However, the current enrichment methods for O-phosphopeptides are not preferred for N-phosphopeptides due to the intrinsic lability of P-N bond under acidic conditions. Therefore, the effective N-phosphoproteome anal. remains challenging. Herein, bis(zinc(II)-dipicolylamine)-functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) are tailored for rapid and effective N-phosphopeptides enrichment. Due to the coordination of phosphate groups to Zn(II), N-phosphopeptides can be effectively captured under neutral conditions. Moreover, the method is successfully applied to an E.coli and HeLa N-phosphoproteome study. These results further broaden the range of methods for the discovery of N-phosphoproteins with significant biol. functions. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Tuned Al3+ selectivity and π-extended properties of di-2-picolylamine-substituted quinoline-based tolan》 was published in Tetrahedron Letters in 2020. These research results belong to Ko, Min-Sung; Kurapati, Sathish; Jo, Yunhee; Cho, Beomhee; Cho, Dong-Gyu. Name: Bis(pyridin-2-ylmethyl)amine The article mentions the following:

Di-2-picolylamine (DPA)-substituted quinoline-type tolan was synthesized herein. The electron withdrawing CN substituted tolan (1)(I) exhibited clear Al3+ selectivity, unlike simple DPA-substituted quinoline (2). Addnl., owing to the π-extension to quinoline (2), a red shifted fluorescence band and the shoulder of tolan (1) were observed at 491 and 537 nm, resp., whereas the quinoline (2) fluorescence band was observed at approx. 450 nm. Consequently, Al3+ bound tolan was more red shifted in comparison with other metal ions bound by 2. Fluorescence titration of Al3+ to 1 (20μM) in HEPES buffer (10 mM, pH = 7.4) containing 50% MeOH exhibited a limit of detection of 36 nM. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Name: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Name: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Highly Efficient and Selective Visible-Light Driven CO2 Reduction by Two Co-Based Catalysts in Aqueous Solution》 was written by Zhang, Liyan; Li, Shiwei; Liu, Huiping; Cheng, Yuan-Sheng; Wei, Xian-Wen; Chai, Xiaomin; Yuan, Guozan. Category: pyridine-derivativesThis research focused onVisible Light driven CO2 reduction cobalt catalyst aqueous solution; crystal structure cobalt dipicolylamine complex; Fluorescence lifetime ruthenium phenanthroline cobalt complex catalyst. The article conveys some information:

Photocatalytic CO2 reduction has been considered as a promising approach to solve energy and environmental problems. Nevertheless, developing inexpensive photocatalysts with high efficiency and selectivity remains a big challenge. In this study, two Co-based complexes [Co2(L1)Cl2] I (1-Co) and [Co(L2)Cl] II (2-Co) were synthesized by treating two DPA-based (DPA: dipicolylamine) ligands with Co2+, resp. Under visible-light irradiation, the performance of 1-Co as a homogeneous photocatalyst for CO2 reduction in aqueous media has been explored by using [Ru(phen)3]2+ as a photosensitizer, and triethylolamine (TEOA) as a sacrificial reductant. 1-Co shows high photocatalytic activity for CO2-to-CO conversion, corresponding to the high TONCO of 2600 and TOFCO of 260 h-1 (TONCO = turnover number for CO; TOFCO = turnover frequency for CO). High selectivity of 97% for CO formation is also achieved. The control experiments catalyzed by 2-Co demonstrated that two Co(II) centers in 1-Co may operate independently and activate one CO2 mol. each. Furthermore, the proposed mechanism of 1-Co for photocatalytic CO2 reduction has been investigated via electrochem. anal., a series of quenching experiments, and d. functional theory calculations In aqueous solution, two Co-based complexes display high photocatalytic activity, selectivity, and durability for CO2-to-CO conversion. The photocatalytic mechanism of 1-Co has been investigated in detail. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pei, Di; Liu, Bo; Zhao, Shuai; Shu, Xin; Nie, Jun; Chang, Yincheng published their research in ACS Applied Bio Materials in 2021. The article was titled 《Controllable Release Mode Based on ATP Hydrolysis-Fueled Supra-Amphiphile Assembly》.Formula: C12H13N3 The article contains the following contents:

The controllable intermittent and stepwise release modes were achieved in a dissipative system of supra-amphiphile. The supra-amphiphile was constructed based on complexation of cationic amphiphile (Zn@DPA-14) and biol. energy currency, ATP. The formation of supra-amphiphile and the competing hydrolysis of ATP by enzyme drove the micelles assembled by Zn@DPA-14 away from the thermodn. equilibrium state, leading to the cargo release from micelles during the process of micelles transformed to vesicles. Following the time-dependent evolution, the intermittent release or stepwise release modes of the loaded cargo realized through adjusting the polarity of the cargo mols. The strategy advancing from “”traditional”” release modes under thermodn. control toward the life-like controllable modes in the far-from-equilibrium state shows unique potential applications on transport vehicles and biomedical field. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Formula: C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem