Category: 1539-42-0

Bhattacharyya, Arnab; Jameei, Aida; Saha, Rupak; Garai, Aditya; Karande, Anjali A.; Chakravarty, Akhil R. published their research in Dalton Transactions in 2021. The article was titled 《BODIPY-linked cis-dichlorido zinc(II) conjugates: the strategic design of organelle-specific next-generation theranostic photosensitizers》.Recommanded Product: 1539-42-0 The article contains the following contents:

Dipicolylamine (dpa) based cis-dichlorido zinc(II) complexes [Zn(L1-3)Cl2] (1-3), where L2 and L3 are non-iodo and di-iodo BODIPY-appended dpa in 2 and 3, and L1 is dpa in control complex 1, were prepared and characterized and their photocytotoxicity was studied. Complexes 2 and 3 were developed as potential substitutes for zinc(II)-porphyrins/phthalocyanines that are photodynamic therapeutic agents with moderate activity owing to their inherent hydrophobicity and aggregation-induced deactivation mechanism. In authors approach, they strategically designed hybrid inorganic-organic zinc-BODIPY conjugates as theranostic photosensitizers. The structurally characterized diamagnetic Zn(II) cis-dichlorido complexes mimic cisplatin and serve as new-generation photosensitizers with enhanced aqueous solubility and mito-DNA targeting propensity while imparting significant physiol. stability to the heavy atom tethered BODIPY ligand, L3. The BODIPY complexes showed a visible band near 500 nm (ε ~34 000-44 000 dm3 mol-1 cm-1) and an emission band at 507 nm for 2 in 1% DMSO-Dulbecco’s phosphate buffered saline. The labile chlorido ligands (ΛM ~200 S m2 mol-1 in 9 : 1 H2O-DMSO) generated pos. charged complexes inside the cellular medium enabling them to cross the mitochondrial membrane for this organelle-selective localization and singlet oxygen-mediated apoptotic photocytotoxicity at nanomolar concentrations for 3 in HeLa and MCF-7 cells in light (400-700 nm), while being less active in the dark.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Phosphate and polyphosphate anion recognition by a dinuclear copper(II) complex of an unsymmetrical squaramide》 were Esteves, Catarina V.; Costa, Judite; Esteban-Gomez, David; Lamosa, Pedro; Bernard, Helene; Platas-Iglesias, Carlos; Tripier, Raphael; Delgado, Rita. And the article was published in Dalton Transactions in 2019. Safety of Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

In the search for receptors suitable for the recognition of phosphate or polyphosphate anions, a new unsym. squaramide-based ligand bearing dipicolylamine (dpa) and ethylpiperazine units (L) (I) was designed and prepared The acid-base reactions of L, its copper(II) complexation behavior and the binding of phosphate and polyphosphate anions by the copper(II) complexes used as receptors were evaluated. 1H and 13C NMR titrations of L performed in D2O allowed the determination of its protonation sequence. The ligand L is able to coordinate two copper(II) cations forming thermodynamically stable dinuclear complexes likely having two water mols. bound to each metal center, as supported by DFT calculations Coordinated water mols. can be replaced by the O-donors of the phosphate/polyphosphate anions. The potentiometric studies showed that at 2 : 1 Cu2+ : L ratio the dinuclear [Cu2LH-1]3+ species predominates from pH ∼ 5 to ∼7, and hydroxodinuclear species prevail at pH > 7. 1H NMR experiments in both H2O/D2O 9 : 1 volume/volume and in DMSO proved that copper(II) coordination provokes deprotonation of the squaramide NH bound to the ethylpiperazine moiety, resulting in [Cu2LH-1]3+ species. The dicopper(II) complexes of L, [Cu2LH-i]4-i, were used as the receptor for the uptake of some phosphate and polyphosphate anions. The receptor presents very high association constants with HPPi3- and ATP4- and the determined Keff showed that at physiol. pH ATP4- is selectively taken from an aqueous solution containing phenylphosphate (PhPO42-), aminoethylphosphate (Haep-), AMP2- and ADP3-, but HPPi3- strongly interferes. DFT calculations suggest that the strong interaction with HPPi3- and ATP4- is related to the simultaneous coordination of the polyphosphate unit to the two copper(II) centers. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Safety of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Safety of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells》 was written by Horton, Timothy M.; Allegretti, Paul A.; Lee, Sooyeon; Moeller, Hannah P.; Smith, Mark; Annes, Justin P.. Electric Literature of C12H13N3This research focused onzinc DYRK1A insulin pharmacophore pancreatic beta cell; chelation; diabetes; islet; targeted compound delivery; targeting; tissue selectivity; zinc; β cell; β-cell regeneration; β-cell-replication. The article conveys some information:

Diabetes is a hyperglycemic condition characterized by pancreatic β-cell dysfunction and depletion. Whereas methods for monitoring β-cell function in vivo exist, methods to deliver therapeutics to β cells are lacking. We leveraged the rare ability of β cells to concentrate zinc to preferentially trap zinc-binding mols. within β cells, resulting in β-cell-targeted compound delivery. We determined that zinc-rich β cells and islets preferentially accumulated TSQ (6-methoxy-8-p-toluenesulfonamido-quinoline) in a zinc-dependent manner compared with exocrine pancreas. Next, we asked whether appending a zinc-chelating moiety onto a β-cell replication-inducing compound was sufficient to confer preferential β-cell accumulation and activity. Indeed, the hybrid compound preferentially accumulated within rodent and human islets in a zinc-dependent manner and increased the selectivity of replication-promoting activity toward β cells. These data resolve the fundamental question of whether intracellular accumulation of zinc-chelating compounds is influenced by zinc content. Furthermore, application of this principle yielded a proof-of-concept method for β-cell-targeted drug delivery and bioactivity. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2020 ,《Synthesis, characterization and photoinduced CO-release by manganese(I) complexes》 appeared in New Journal of Chemistry. The author of the article were Amorim, Andre L.; Guerreiro, Ana; Glitz, Vinicius A.; Coimbra, Daniel F.; Bortoluzzi, Adailton J.; Caramori, Giovanni F.; Braga, Antonio L.; Neves, Ademir; Bernardes, Goncalo J. L.; Peralta, Rosely A.. The article conveys some information:

Herein, authors report the CO-releasing activity of three new photoCORMs, two with nonbonding pyridine moieties and one with a benzyl group. Compounds [MnBr(CO)3(bpa-κ2)] (2, where bpa = N-benzyl(2-pyridylmethyl)amine); [MnBr(CO)3(pmpea-κ2)] (3, where pmpea = N-(2-pyridylmethyl)-N’-(2-pyridylethyl)amine) and [MnBr(CO)3(bpea-κ2)] (4, where bpea = N-bis(2-pyridylethyl)amine) were synthesized and characterized by common spectroscopic techniques (UV-Vis and IR). D. functional theory studies were also performed to provide new insights into the M-C bond and to assume the orbitals involved in the absorption transitions. Their CO-releasing activities were measured both in organic and in physiol. media and compared to that of a previously published compound [Mn(CO)3(dpa-κ3)]Br (1, where dpa = N-bis(2-pyridylmethyl)amine). An increase in the number of members of the chelate from five to six influenced the release of CO, affecting both the binding mode of the ligand and the CO-release process and affecting their potential use as CO-release carriers and therapeutic agents. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemistry – A European Journal included an article by Ramu, Vadde; Upendar Reddy, Gandra; Liu, Jingjing; Hoffmann, Patrick; Sollapur, Rudrakant; Wyrwa, Ralf; Kupfer, Stephan; Spielmann, Christian; Bonnet, Sylvestre; Neugebauer, Ute; Schiller, Alexander. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine. The article was titled 《Two-Photon-Induced CO-Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells》. The information in the text is summarized as follows:

Phototherapeutic applications of carbon monoxide (CO)-releasing mols. are limited because they require harmful UV and blue light for activation. We describe two-photon excitation with NIR light (800 nm)-induced CO-release from two MnI tricarbonyl complexes bearing 1,8-naphthalimide units (1, 2). Complex 2 behaves as a logic OR gate in solution, nonwovens, and in HeLa cells. CO release, indicated by fluorescence enhancement, was detected in solution, nonwoven, and HeLa cells by single- (405 nm) and two-photon (800 nm) excitation. The photophys. properties of 1 and 2 have been measured and supported by DFT and TDDFT quantum chem. calculations Both photoCORMs are stable in the dark in solution and noncytotoxic, leading to promising applications as phototherapeutics with NIR light. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Smart Responsive Luminescent Aptamer-Functionalized Covalent Organic Framework Hydrogel for High-Resolution Visualization and Security Protection of Latent Fingerprints》 were Hai, Jun; Wang, Hao; Sun, Panpan; Li, Tianrong; Lu, Siyu; Zhao, Yang; Wang, Baodui. And the article was published in ACS Applied Materials & Interfaces in 2019. Synthetic Route of C12H13N3 The author mentioned the following in the article:

Covalent organic frameworks (COFs) have been proposed as alternative candidates for “”smart”” materials due to its ordered π-columnar structures. However, it remains a challenge to develop external-stimuli-responsive luminescent COFs for confidential information protection. Here we have designed and synthesized a water-dispersible and smart responsive luminescent CM-cellulose (CMC)-COF-LZU1 hydrogel with encapsulated 5-(Dimethylamino)-N,N-bis (pyridin-2-ylmethyl) naphthalene-1-sulfonamide (DPYNS), named CMC-COF-LZU1⊃DPYNS, for LFP imaging and encryption. We show that the fluorescence of CMC-COF-LZU1⊃DPYNS is reversibly switchable upon addition of Cu2+/H2O. This effect endows potential applications of tunable luminescent COFs based hydrogel as an invisible security probe for imaging, record, storage, and security of latent fingerprint information. It is shown that the latent fingerprint information incubated by the CMC-COF-LZU1⊃DPYNS hydrogel is invisible in the presence of Cu2+, but three levels of fingerprint features with high-resolution patterns can be readable upon addition of H2O under UV light. The design strategy provides a promising platform for the development of smart responsive luminescent COFs and their detection and protection of valuable LFP information. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haller, Paulina; Machado, Ignacio; Torres, Julia; Vila, Agustina; Veiga, Nicolas published an article in 2021. The article was titled 《Fe(III)-Complex-Imprinted Polymers for the Green Oxidative Degradation of the Methyl Orange Dye Pollutant》, and you may find the article in Polymers (Basel, Switzerland).COA of Formula: C12H13N3 The information in the text is summarized as follows:

One of the biggest problems worldwide is the pollution of natural water bodies by dyes coming from effluents used in the textile industry. In the quest for novel effluent treatment alternatives, the aim of this work was to immobilize Fe(III) complexes in molecularly imprinted polymers (MIPs) to produce efficient Fenton-like heterogeneous catalysts for the green oxidative degradation of the methyl orange (MO) dye pollutant. Different metal complexes bearing com. and low-cost ligands were assayed and their catalytic activity levels towards the discoloration of MO by H2O2 were assessed. The best candidates were Fe(III)-BMPA (BMPA = di-(2-picolyl)amine) and Fe(III)-NTP (NTP = 3,3′,3”-nitrilotripropionic acid), displaying above 70% MO degradation in 3 h. Fe(III)-BMPA caused the oxidative degradation through two first-order stages, related to the formation of BMPA-Fe-OOH and the generation of reactive oxygen species. Only the first of these stages was detected for Fe(III)-NTP. Both complexes were then employed to imprint catalytic cavities into MIPs. The polymers showed catalytic profiles that were highly dependent on the crosslinking agent employed, with N,N-methylenebisacrylamide (MBAA) being the crosslinker that rendered polymers with optimal oxidative performance (>95% conversion). The obtained ion-imprinted polymers constitute cheap and robust solid matrixes, with the potential to be coupled to dye-containing effluent treatment systems with synchronous H2O2 injection.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Femtomolar detection of Cu2+ ions in solution using super-Nernstian FET-sensor with a lipid monolayer as top-gate dielectric》 was published in Sensors and Actuators, B: Chemical in 2020. These research results belong to Kenaan, A.; Brunel, F.; Raimundo, J.-M.; Charrier, A. M.. Product Details of 1539-42-0 The article mentions the following:

The development of ions sensors with low limit of detection and high sensitivity and selectivity is required in many fields of application and still remains a challenge. We report on the first dual-gated field effect transistor sensor with an engineered lipid monolayer as top gate dielec. The sensor was designed and fabricated for the specific detection of Cu2+ using the Di-2-picolylamine as recognition unit. The lipid monolayer was reticulated to achieve high mech. and dielec. stability over device operation. The resulting sensor exhibits exceptional performances with a limit of detection at 10 femtomolar, with a linear dependency over 10 decades and a super-Nernstian sensitivity of ∼100 mV/decade. We also show that the lipid layer forms a good barrier to ions trapping, hence providing a high stability of the sensor over measurements. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chemosensing of Guanosine Triphosphate Based on a Fluorescent Dinuclear Zn(II)-Dipicolylamine Complex in Water》 was published in Inorganic Chemistry in 2020. These research results belong to Bazany-Rodriguez, Ivan J.; Salomon-Flores, Maria K.; Bautista-Renedo, Joanatan M.; Gonzalez-Rivas, Nelly; Dorazco-Gonzalez, Alejandro. Recommanded Product: Bis(pyridin-2-ylmethyl)amine The article mentions the following:

Guanosine triphosphate (GTP) is a key biomarker of multiple cellular processes and human diseases. The new fluorescent dinuclear complex [Zn2(L)(S)][OTf]4, 1 (asym. ligand, L = 5,8-Bis{[bis(2-pyridylmethyl)amino] methyl}quinoline, S = solvent, and OTf = triflate anion) was synthesized and studied in-depth as a chemosensor for nucleoside polyphosphates and inorganic anions in pure water. Additions at neutral pH of nucleoside triphosphates, guanosine diphosphate, guanosine monophosphate, and pyrophosphate (PPi) to 1 quench its blue emission (λem = 410 nm) with a pronounced selectivity toward GTP over other anions, including ATP (ATP), uridine triphosphate (UTP), and cytidine triphosphate (CTP). The efficient quenching response by the addition of GTP was observed in the presence of coexisting species in blood plasma and urine with a detection limit of 9.2 μmol L-1. GTP also shows much tighter binding to the receptor 1 on a submicromolar level. On the basis of multiple spectroscopic tools (1H, 31P NMR, UV-vis, and fluorescence) and DFT calculations, the binding mode is proposed through three-point recognition involving the simultaneous coordination of the N7 atom of the guanosine motif and two phosphate groups to the two Zn(II) atoms. Spectroscopic studies, MS-ESI, and DFT suggested that GTP bound to 1 in 1:1 and 2:2 models with high overall binding constants of log β1 (1:1) = 6.05 ± 0.01 and log β2 = 10.91 ± 0.03, resp. The optical change and selectivity are attributed to the efficient binding of GTP to 1 by the combination of a strong electrostatic contribution and synergic effects of coordination bonds. Such GTP selectivity of an asym. metal-based receptor in water is still rare. The blue fluorescent Zn(II)-dinuclear complex, 1, based on the new 5,8-bis{[bis(2-pyridylmethyl)amino]methyl}quinoline ligand was designed, synthesized, and studied in depth as a chemosensor for nucleoside polyphosphates (NPPs) in neutral pure water. The fluorescence emission of 1 is affected strongly by the NPPs with pronounced selectivity toward guanosine triphosphate (GTP). This optical change is the result of the coordination of GTP to 1 through three-point recognition. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C12H13N3In 2021 ,《Optimization of signal amplification by reversible exchange for polarization of tridentate chelating bis[(2-pyridyl)alkyl]amine》 was published in Analyst (Cambridge, United Kingdom). The article was written by Min, Sein; Chae, Heelim; Jeong, Hye Jin; Kim, Kiwoong; Namgoong, Sung Keon; Jeong, Keunhong. The article contains the following contents:

Signal amplification by reversible exchange (SABRE) is an effective NMR hyperpolarization technique for signal enhancement using para-hydrogen on iridium catalysts. To date, monodentate chelating nitrogen analogs have been predominantly used as substrates for SABRE because of the limited chelating sites of the Ir-catalyst with different mol. orientations. Herein, for the first time, the use of a tridentate chelating ligand (BPEA) containing pyridine moieties and a secondary amine as a SABRE substrate is demonstrated. For the optimization of the tridentate chelating ligand, alkyl chain lengths were varied with the optimization of the external magnetic field and concentrations of three different ligands. Because many chem. multidentate complexes present in nature have scarcely been studied as SABRE substrates, this optimized tridentate chelating ligand structure with the SABRE catalyst and its polarization transfer from para-hydrogen will broaden the scope of hyperpolarizable substrates and help in the investigation of chelating structures for future applications. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Computed Properties of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Computed Properties of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem