Category: 1539-42-0

Synthetic Route of C12H13N3In 2019 ,《Molecular design for novel sensing materials with self-screening interference effect (SSIE): Reversible recognizing Cu2+ in aqueous and biologic samples》 appeared in Sensors and Actuators, B: Chemical. The author of the article were Zhao, Gang; Song, Fangfang; Wei, Gang; Wu, Rongliang; Yan, Zhengquan; Zhang, Fayin; Guang, Shanyi; Xu, Hongyao. The article conveys some information:

In the work, self-screening interference effect (SSIE) was proposed for sensing trace Cu2+ by simply thermodn. control reactions, using dipyridine as self-screening interference group, rhodamine as mother chromophore and cyanuric chloride as connecting bridge. After its UV-vis and fluorescent spectral properties were optimized in detail, it was noted to find that the present sensing material (RACD) could selectively and reversibly react Cu2+ with obvious colorimetric or fluorescent spectral and color changes from colorless to pink or orange-red. Some other concomitant ions, even trivalent Fe3+ or Al3+, had no interferences on it. Under the optimized conditions, RACD could multiple-mode sense trace Cu2+ in aqueous with a detection limit as low as 11.0 nmol/L. Especially with low toxicity, RACD was successfully applied for quant. monitoring Cu2+ and evaluating its toxicity in living cells and bio-tissues. RACD-functionalized paper-strips were also prepared to visibly recognize Cu2+ more conveniently. The selective action mechanism for RACD to Cu2+ was to form some stable 5-membered and 5-membered condensed rings between Cu2+ and O or N atoms. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1539-42-0In 2020 ,《Tridentate bis(2-pyridylmethyl)amine iron catalyst for electrocatalytic proton reduction》 appeared in Inorganica Chimica Acta. The author of the article were Schiffman, Zachary R.; Margonis, Caroline M.; Moyer, Allison; Ott, Michelle; McNamara, William R.. The article conveys some information:

For widespread applicability, successful complexes for catalytic hydrogen generation should be inexpensive and easy to synthesize. To this end, a series of tetradentate Fe(III) polypyridyl monophenolate complexes was recently reported that are stable and active electrocatalysts for reducing protons into hydrogen gas. While these complexes were active for hydrogen generation, the ligands were synthesized in moderate to good yield after multiple synthetic steps. Herein the authors report a tridentate iron dipyridyl amine analog for hydrogen generation that was synthesized in a single synthetic step from com. available materials. The resulting complex is an active electrocatalyst operating at -0.95 V vs. SHE (-1.57 V vs. Fc+/Fc) with a TOF = 16 s-1. The complex is also a precatalyst for photocatalytic hydrogen evolution when paired with fluorescein (chromophore) and triethylamine (sacrificial electron source) in a 1:1 ethanol:water mixture After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Molecular Structure included an article by Ishak, Syarmila; Yeap, Guan-Yeow; Shanmugapriya; Sasidharan, Sreenivasan; Ito, Masato M.. Recommanded Product: 1539-42-0. The article was titled 《Synthesis, molecular structure and cytotoxic studies of fluorene compound with potential anti-cancer properties》. The information in the text is summarized as follows:

A new fluorene derivative, I has been successfully synthesized through condensation reaction of bis(2-pyridylmethyl)amine and 2,7-bis-bromomethyl-9,9-dihexyl-9H-fluorene with exceptionally good yield. The mol. structure of the synthesized compound was well characterized by NMR (NMR), IR (FTIR), UV-vis absorption and fluorescence techniques. The in-vitro anticancer activity of the title compound against human cervical (HeLa) cancer cell line was validated wherein the target mol. exhibits IC50 value of 28.58 μg/mL (37.76 μM). The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Experimental, quantum computational study and in vitro antidiabetic activity of oxidovanadium(IV) complexes incorporating 2,2′-bis(pyridylmethyl)amine and polypyridyl ligands》 was written by Patel, Neetu; Prajapati, A. K.; Jadeja, R. N.; Tripathi, I. P.; Dwivedi, N.. Computed Properties of C12H13N3This research focused onvanadyl pyridylmethyl amine diimine complex preparation DFT calculation; magnetic property cyclic voltammetry vanadyl pyridylmethyl amine diimine complex; antidiabetic activity vanadyl pyridylmethyl amine diimine complex. The article conveys some information:

This article describes synthesis and characterization of three oxidovanadium(IV) complexes using BPA (BPA = 2,2′-bis(pyridylmethyl)amine), 2,2-bipyridyl and 1,10-phenanthroline. These complexes were characterized by elemental anal., spectroscopic (UV-visible, IR and EPR) and electrochem. methods. Room temperature magnetic susceptibility data show the paramagnetic nature of the complexes. Complexes were also characterized by EPR spectral techniques. The optimized mol. structures show N3O3/N5O donor atoms in six-coordinate geometry. These complexes were evaluated and compared using TGA and powder x-ray diffraction techniques. The species exhibit only one-electron reduction wave at a more neg. potential. The catalytic activity of these complexes was also explored to mimic α-glucosidase and α-amylase activity. Moderate α-glucosidase and α-amylase inhibitors are shown by all complexes. These observations are expected to expand the possibility of designing new oxidovanadium(IV) complexes with significant anti-diabetic properties. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Computed Properties of C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Computed Properties of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Bis(pyridin-2-ylmethyl)amineIn 2022 ,《Synthesis, characterization, structural, redox and electrocatalytic proton reduction properties of cobalt polypyridyl complexes》 appeared in Inorganica Chimica Acta. The author of the article were Karumban, Kalai Selvan; Muley, Arabinda; Giri, Bishnubasu; Kumbhakar, Sadananda; Kella, Tatinaidu; Shee, Debaprasad; Maji, Somnath. The article conveys some information:

A monoanionic amido pentadentate ligand bpaqH (2-(bis(pyridin-2-ylmethyl)amino)-N-(quinolin-8-yl)acetamide) and its corresponding cobalt(III) chloro complex [Co(bpaq)Cl]Cl: 1 and aqua derivative [Co(bpaq)(OH2)](ClO4)2: 2 were successfully synthesized and fully characterized by different anal. and spectroscopic techniques such as FT-IR, 1H NMR, UV-vis spectroscopy, ESI mass spectra. The structures of 1 and 2 have been determined by the single-crystal x-ray diffraction. Spectral and redox properties were investigated along with free ligand under electrochem. conditions. Both complexes performed proton reduction activity under soluble, diffusion-limited conditions in acetonitrile with acetic acid as an external proton source with overpotentials of 0.412 V for 1 and 0.394 V for 2. The stability of the catalysts was inspected by the time-dependent UV-vis spectroscopy; 1 and 2 were highly stable in the absence and presence of acetic acid. There was no significant spectral change before and after the controlled potential electrolysis suggesting no change in mol. integrity during electrocatalysis. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Lactide polymerization using sterically encumbered, flexible zinc complex》 was written by Dordahan, Fatemeh; Schaper, Frank. Reference of Bis(pyridin-2-ylmethyl)amineThis research focused onzinc complex catalyst preparation lactide polymerization. The article conveys some information:

4-(Tert-Butyl)-2-trityl-6-(di-(2-picolyl)amine)phenol, LH, was prepared from paraformaldehyde, 4-(tert-butyl)-2-tritylphenol, and di-(2-picolyl)amine. Reaction with Zn(N(SiMe3)2)2 gave LZnN(SiMe3)2. The complex was shown by X-ray diffraction study, variable temperature NMR, and DFT calculations to coordinate only one pyridine ligand, which allows for fast and facile complex isomerisation. LZnN(SiMe3)2 was active in rac-lactide polymerization, but in contrast to previous complexes of this type, it did not show any evidence for isotactic monomer enchainment via a catalytic-site mediated chain-end control mechanism. Addition of alc. led to increased activity, but the complex was unstable in the presence of free alc. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The first structurally characterized sulfonamide derivatized Zn(II)-dipicolylamine complexes with eight membered chelate rings. Synthetic and structural studies》 was written by Darshani, Taniya; Weldeghiorghis, Thomas K.; Fronczek, Frank R.; Perera, Theshini. COA of Formula: C12H13N3This research focused onzinc dipicolylamine naphthalenesulfonyl eight membered preparation crystal mol structure. The article conveys some information:

Di(2-picolyl)amine has attracted a great deal of attention as the most popular chelating group in synthesizing biol. sensors to detect zinc(II) ions. This study reveals the first structurally characterized zinc complexes of the sulfonamide derivatized di(2-picolyl)amine (dpa) moiety with a rare eight membered chelate ring. The novel synthesized zinc(II) complexes; Zn(N(SO2R1)dpa)Cl2 (C1), Zn(N(SO2R2)dpa)Cl2 (C2), Zn(N(SO2R3)dpa)Cl2 (C3), where R1 = 1-naphthalene, R2 = 2-naphthalene, R3 = 5-(dimethylamino)naphthalene were characterized using single crystal x-ray diffraction anal., 1H NMR, FTIR, UV-Visible and fluorescence spectroscopy. Structural anal. showed that the complexes possess distorted tetrahedron geometry around the zinc center and that the zinc metal center is bound to the two pyridyl nitrogens of the dpa group in a bidentate fashion creating a large eight membered chelate ring. The signal attributed to the methylene group (CH2) in the free ligand spectra remains a singlet in the 1H NMR spectra of the zinc complexes but has shifted more downfield. Spectral studies of the complexes revealed that the complexes are fluorescent at concentrations of 0.1 mM with intense fluorescence peaks (C1: 335 nm, C2: 343 nm and C3: 528-551 nm) and, thus, can be further investigated on their potential to be used as imaging agents or biol. sensors. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Clark, Brandon; Gilles, Genesis; Tarpeh, William A. published an article in 2022. The article was titled 《Resin-Mediated pH Control of Metal-Loaded Ligand Exchangers for Selective Nitrogen Recovery from Wastewaters》, and you may find the article in ACS Applied Materials & Interfaces.Product Details of 1539-42-0 The information in the text is summarized as follows:

Highly selective separation materials that recover total ammonia nitrogen (i.e., ammonia plus ammonium, or TAN) from wastewaters as a pure product can supplement energy-intensive ammonia production and incentivize pollution mitigation. We recently demonstrated that com. acrylate cation exchange polymer resins loaded with transition metal cations, or metal-loaded ligand exchangers, can recover TAN from wastewater with high selectivity (TAN/K+ equilibrium selectivity of 10.1) via metal-ammine bond formation. However, the TAN adsorption efficiency required further improvement (35%), and the optimal concentration and pH ranges were limited by both low ammonia fractions and an insufficiently strong resin carboxylate-metal bond that caused metal elution. To overcome these deficiencies, we used a zinc-acrylate ligand exchange resin and a tertiary amine acrylic weak base resin (pH buffer resin) together to achieve resin-mediated pH control for optimal adsorption conditions. The high buffer capacity around pH 9 facilitated gains in the adsorbed TAN per ligand resin mass that enhanced the TAN adsorption efficiency to greater than 90%, and constrained zinc elution (below 0.01% up to 1 M TAN) because of decreased ammonia competition for zinc-carboxylate bonds. During TAN recovery, resin-mediated pH buffering facilitated recovery of greater than 99% of adsorbed TAN with 0.2% zinc elution, holding the pH low enough to favor ammonium but high enough to prevent carboxylate protonation. For selective ion separation, solid phase buffers outperform aqueous buffers because the initial solution pH, the buffering capacity, and the ion purity can be independently controlled. Finally, because preserving the resin-zinc bond is crucial to sustained ligand exchange performance, the properties of an ideal ligand resin functional group were investigated to improve the properties beyond those of carboxylate. Ultimately, ligand exchange adsorbents combined with solid pH buffers can advance the selective recovery of nitrogen and potentially other solutes from wastewaters. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Fluorescent enhancement sensing of cadmium (II) ion based on a perylene bisimide derivative》 were Xiong, Jiu-Kai; Wang, Ke-Rang; Wang, Kai-Xin; Han, Tian-Lei; Zhu, Hong-Yu; Rong, Rui-Xue; Cao, Zhi-Ran; Li, Xiao-Liu. And the article was published in Sensors and Actuators, B: Chemical in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

A perylene bisimide derivative (PBI-Lac-DPA) with lactose and DPA moiety conjugates was synthesized, and this compound exhibited fluorescence turn-on sensing for Cd2+ ions in an aqueous solution with a binding constant of (6.0 ± 0.3) × 104 M-1, and detection limit of 5.2 ± 10-7 M. PBI-Lac-DPA exhibited high selectivity for the Cd2+ ion with a 2:1 binding stoichiometry between PBI-Lac-DPA and Cd2+ ions due to the addnl. coordinating sites in the self-assembly process of PBI-Lac-DPA itself. Furthermore, PBI-Lac-DPA exhibited fluorescence enhancement upon complexation with the Cd2+ ion in living cells. This work explored a new method for increasing the selectivity for Cd2+ ions via the enhanced addnl. complex sites of the DPA moiety from self-assembly process. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《pH-Switchable Coordinative Micelles for Enhancing Cellular Transfection of Biocompatible Polycations》 were Zhang, Qingyan; Zhou, Zhanwei; Li, Chenzi; Wu, Pengkai; Sun, Minjie. And the article was published in ACS Applied Materials & Interfaces in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Inefficient transfection of biocompatible low-mol.-weight (LMW) polycations, such as 1.8k polyethylenimine (PEI), is a major challenge for successful nucleic acid delivery. Current strategies to improve transfection efficiency are bottlenecked by maintaining the balance between efficient gene encapsulation and on-demand cargo release. Here, we developed a new class of Zn(II)-coordinated micelles, which showed tight small interfering RNA (siRNA) binding and pH-switchable release. The dipicolylamine-modified PEI 1.8k (PD) and dopamine-conjugated cholesterol (Chol-Dopa) assemble into coordinative micelles (Zn-PD/Chol-Dopa) via the coordination of 2,2′-dipicolylamine (DPA) and Dopa through Zn(II) as a bridge. The high phosphate-binding affinity of Zn-DPA enhanced the siRNA packaging and the interaction between cholesterol and cell membranes enhanced cellular uptake. Moreover, the coordination effect weakened in the acidic environment of lyso/endosome, triggering the disassembly of micelles and siRNA release. These properties of the micelles resulted in strong siRNA transfection efficiencies in various cell lines. Our strategy of constructing coordinative micelles improves the transfection efficiency of LMW PEI and holds tremendous potential to develop the endogenous responsive gene delivery systems. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem