Category: 1539-42-0

《A new tripodal 8-hydroxyquinoline as a high sensitivity fluorescence sensor for Zn(II) in ethanol and its two morphology in solid》 was written by Kong, Mengjiao; Xing, Feifei; Zhu, Shourong. Recommanded Product: Bis(pyridin-2-ylmethyl)amineThis research focused onzinc hydroxyquinolinlymethylbipyridinylmethylamine complex preparation fluorescent sensor; crystal structure zinc hydroxyquinolinlymethylbipyridinylmethylamine complex. The article conveys some information:

A new tripodal chelate HL was synthesized from tridentate chelate bis(pyridin-2-ylmethyl)amine (BPA) and 8-hydroxyquinoline (8-HQ) to increase interaction between HL and Zn2+ and improve fluorescence sensitivity. Asym. and sym. dinuclear Zn(II) complex in rod and block shape were formed in CH3CN with identical formula, 1H NMR and fluorescence spectra in solution, but different IR, TG, and PXRD in solid. The fluorescence quantum yields are 0.0145 and 0.602 for HL and [ZnL]2+2 in ethanol resp. LOD reached 2.3 nM Zn2+, which is the highest sensitivity. The 7-position functionalization of 8-HQ is critical to the strong coordination and high fluorescence sensitivity. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ditopic dithiocarbamate ligands for the production of trinuclear species》 was published in Arabian Journal of Chemistry in 2020. These research results belong to Marin-Carrillo, Edgar; Ruiz-Martinez, Adrian; Valdes, Hugo; Reyes-Martinez, Reyna; Hernandez-Ortega, Simon; Adriana Aguilar-Castillo, Bethsy; Morales-Morales, David. Application of 1539-42-0 The article mentions the following:

Reactions of group 10 transition metals with the ditopic ligand dipicolyldithiocarbamate (DPDTC) were performed. Thus, 1:2 reactions of [Ni(CH3COO)2], [Pd(COD)Cl2] or [Pt(COD)Cl2] with DPDTC produced monomeric complexes of the type [M(κ2-SCS-DPDTC)2, M = Ni (1), Pd (2) or Pt (3)] with the dithiocarbamate ligand (DTC) coordinated in a typical chelate κ2-SCS fashion. Interestingly, the reaction of [NiCl2] with DPDTC, under similar conditions, afforded the organic compound 2-(pyridin-2-ylmethyl)imidazo[1,5-a]pyri-dine-3(2 H)-thione (4) as unique product. In order to prove the ditopic nature of the ligand DPDTC, complex [Pd(κ2-SCS-DPDTC)2] (2) was further reacted with [ZnCl2] in a 1:2 M ratio to yield the trinuclear complex [Cl2Zn(κ2-NN-DPDTC-SCS-κ2)Pd(κ2-SCS-DPDTC-NN-κ2)ZnCl2] (5). The mol. structures of all compounds were determinate by typical anal. techniques including the unequivocal determination of all structures by single crystal x-ray diffraction anal. As expected, complexes 1-3 are isostructural, and the metal centers exhibiting slightly distorted square-planar geometries. While in 5, the trinuclear nature of the complex in confirmed exhibiting a nice combination of tetrahedral-square planar-tetrahedral geometries for the Zn-Pd-Zn centers resp. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Sensors and Actuators, B: Chemical included an article by Dugandzic, Vera; Kupfer, Stephan; Jahn, Martin; Henkel, Thomas; Weber, Karina; Cialla-May, Dana; Popp, Juergen. Related Products of 1539-42-0. The article was titled 《A SERS-based molecular sensor for selective detection and quantification of copper(II) ions》. The information in the text is summarized as follows:

A novel SERS-based mol. sensor for detection and quantification of copper(II) ions with very good specificity and selectivity is reported in this work. The sensing is enabled by the employment of a synthesized dipicolylamine-based ligand anchored onto plasmonic gold nanoparticles through the sulfur atom of the methylthio group. The interaction of the ligand with copper(II) ions is followed by changes in the spectral features associated with pyridine ring breathing, as indicated by quantum chem. calculations performed at the d. functional level of theory, which are proportional to the copper(II) concentration The detection of copper(II) was possible down to 5 × 10-8 M in water. The proposed mol. sensor was applied for the detection of copper(II) ions in white wine, with the ability to detect amounts of copper(II) in wine lower than the maximum recommended amount of 7.87 × 10-6 M (0.5μg/mL), indicating that the proposed mol. sensor is of potential interest as a routine test for the control of the copper(II) content in wine during wine production and in the final product. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Tu, Yujie; Liu, Junkai; Zhang, Haoke; Peng, Qian; Lam, Jacky W. Y.; Tang, Ben Zhong. SDS of cas: 1539-42-0. The article was titled 《Restriction of Access to the Dark State: A New Mechanistic Model for Heteroatom-Containing AIE Systems》. The information in the text is summarized as follows:

Restriction of intramol. motion (RIM), as the working mechanism of aggregation-induced emission (AIE), cannot fully explain some heteroatom-containing systems. Now, two excited states are taken into account and a mechanism, restriction of access to dark state (RADS), is specified to elaborate RIM and complete the picture of AIE mechanism. A nitrogen-containing mol. named APA is chosen as a model compound; its weak fluorescence in solution is ascribed to the easy access from the bright (π,π*) state to the close-lying dark (n,π*) state. By either metal complexation or aggregation, the dark state is less accessible due to restriction of the mol. motion leading to the dark state and elevation of the dark state energy, thus the bright state emission is restored. RADS is powerful in elucidating the AIE effect of mols. with excited states favoring non-radiative decay, including overlap-forbidden states such as (n,π*) and CT states, spin-forbidden triplet states, and so on. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2021 ,《Going the dHis-tance: Site-Directed Cu2+ Labeling of Proteins and Nucleic Acids》 was published in Accounts of Chemical Research. The article was written by Gamble Jarvi, Austin; Bogetti, Xiaowei; Singewald, Kevin; Ghosh, Shreya; Saxena, Sunil. The article contains the following contents:

Conspectus: In this Account, we showcase site-directed Cu2+ labeling in proteins and DNA, which has opened new avenues for the measurement of the structure and dynamics of biomols. using ESR (EPR) spectroscopy. In proteins, the spin label is assembled in situ from natural amino acid residues and a metal complex and requires no post-expression synthetic modification or purification procedures. The labeling scheme exploits a double histidine (dHis) motif, which utilizes endogenous or site-specifically mutated histidine residues to coordinate a Cu2+ complex. Pulsed EPR measurements on such Cu2+-labeled proteins potentially yield distance distributions that are up to 5 times narrower than the common protein spin label-the approach, thus, overcomes the inherent limitation of the current technol., which relies on a spin label with a highly flexible side chain. This labeling scheme provides a straightforward method that elucidates biophys. information that is costly, complicated, or simply inaccessible by traditional EPR labels. Examples include the direct measurement of protein backbone dynamics at β-sheet sites, which are largely inaccessible through traditional spin labels, and rigid Cu2+-Cu2+ distance measurements that enable higher precision in the anal. of protein conformations, conformational changes, interactions with other biomols., and the relative orientations of two labeled protein subunits. Likewise, a Cu2+ label has been developed for use in DNA, which is small, is nucleotide independent, and is positioned within the DNA helix. The placement of the Cu2+ label directly reports on the biol. relevant backbone distance. Addnl., for both of these labeling techniques, we have developed models for interpretation of the EPR distance information, primarily utilizing mol. dynamics (MD) simulations. Initial results using force fields developed for both protein and DNA labels have agreed with exptl. results, which has been a major bottleneck for traditional spin labels. Looking ahead, we anticipate new combinations of MD and EPR to further our understanding of protein and DNA conformational changes, as well as working synergistically to investigate protein-DNA interactions. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Molecular Insights Into Di(2-Picolyl) Amine-Induced Cytotoxicity and Apoptosis in Human Kidney (HEK293) Cells》 was published in International Journal of Toxicology in 2020. These research results belong to Satyo, Lindelwa; Amoako, Daniel G.; Somboro, Anou M.; Sosibo, Sphelele C.; Kumalo, Hezekiel M.; Mhlongo, Ndumiso N.; Khan, Rene B.. Category: pyridine-derivatives The article mentions the following:

Di(2-picolyl) amine (DPA) is a pyridine derivative known to chelate metal ions and thus has potential anticancer properties; however, its effect on normal cells remains unchartered necessitating further research. This study, therefore, investigated the mechanistic effects of DPA-induced cytotoxicity and apoptosis in the HEK293 cell line. Methods required that an half the maximum inhibition concentration (IC50) was derived using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Analyses aimed to assess oxidative stress, membrane damage, and DNA fragmentation by means of biochem. assays were performed. Luminometry anal. was carried out to understand the mechanism of apoptosis induction by determining the levels of ATP and the activities of caspase-8, -9, and -3/7. An IC50 of 1,079μM DPA was obtained. Antioxidant effect correlated with a min. increase in reactive oxygen species induced lipid peroxidation. The increase in initiator caspase-8 and -9 and executioner caspase-3/7 activities by DPA-induced apoptosis albeit prompting a decline in the levels of ATP. Furthermore, DPA brought about the following consequences on HEK293 cells: markedly elevated tail lengths of the comets, poly (ADP-ribose) polymerase 1 cleavage, and apoptotic body formation observed in the late stages. The cytotoxic effects of DPA in HEK293 cells may be mediated by induction of apoptosis via the caspase-dependent mechanism. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Bis(pyridin-2-ylmethyl)amineIn 2021 ,《Electrochemical Sensing of Adenosin Triphosphate by Specific Binding to Dipicolylamine Group in Cyclodextrin Supramolecular Complex》 was published in ACS Applied Bio Materials. The article was written by Casulli, Maria Antonietta; Taurino, Irene; Hashimoto, Takeshi; Carrara, Sandro; Hayashita, Takashi. The article contains the following contents:

Electrochem. detection based on cyclodextrin supramol. complexes is founded on the competitive binding between electroactive probes and target mols. This limits their versatility to be used for sensing a broad range of metabolites. In this work, we demonstrate the significant role of zinc ions as well as of β-cyclodextrins modified with dipicolylamine and of a phenylboronic acid-modified ferrocene probe to address a selective electrochem. detection of ATP (ATP). Our findings will definitively have an impact in oncol. point-of-care systems, since a high level of extracellular ATP reveals the inflammatory response due to chemotherapeutic treatments. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《High in vitro and in vivo antitumor activities of luminecent platinum(II) complexes with jatrorrhizine derivatives》 appeared in European Journal of Medicinal Chemistry. The author of the article were Qin, Qi-Pin; Zou, Bi-Qun; Wang, Zhen-Feng; Huang, Xiao-Ling; Zhang, Ye; Tan, Ming-Xiong; Wang, Shu-Long; Liang, Hong. The article conveys some information:

Two highly active anticancer Pt(II) complexes, [Pt(Jat1)Cl]Cl (Pt1) and [Pt(Jat2)Cl]Cl (Pt2), containing jatrorrhizine derivative ligands (Jat1 and Jat2) are described. Cell intake study showed high accumulation in cell nuclear fraction. Pt1 and Pt2 exhibited high selectivity for HeLa cancer cells (IC50 = 15.01 ± 1.05 nM and 1.00 ± 0.17 nM) comparing with HL-7702 normal cells (IC50 > 150μM), by targeting p53 and telomerase. Pt2 containing Jat2 ligand was more potent and showed high selectivity for telomerase. It also caused mitochondria and DNA damage, sub-G1 phase arrest, and a high rate of cell apoptosis at the low dose of 1.00 nM. The HeLa tumor inhibition rate (TIR) of Pt2 was 48.8%, which was even higher than cisplatin (35.2%). In addition, Pt2 displayed green luminescent property and potent telomerase inhibition. Our findings demonstrated the promising development of platinum(II) complexes containing jatrorrhizine derivatives as novel Pt-based anticancer agents. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A BODIPY based emission signal turn-on probe toward multiple heavy metals》 was published in Molecular Crystals and Liquid Crystals in 2020. These research results belong to Li, Xiaochuan; Tian, Guixiu; Shao, Danyang; Xu, Yue; Wang, Yan; Ji, Guangqian; Ryu, Jiwon; Son, Young-A.. SDS of cas: 1539-42-0 The article mentions the following:

A heavy metals sensor (2-N,N-bis(pyridin-2-ylmethyl)methanamine-BODIPY, ) for the recognition of Pb2+, Ba2+, Cr2+, Cd2+, Hg2+, Sn2+, and Zn2+ was developed by anchoring (bis(pyridin-2-ylmethyl)amine) DPA unit to the BODIPY framework. It exhibited excellent sensitivity and selectivity against other competent metal ions. The stoichiometry of and metal ions were determined to be 1:1. The limit of detection of toward Pb2+, Ba2+, Cr2+, Cd2+, Hg2+, Sn2+, and Zn2+ was ranged from 60.07 to 89.37 nM. Photo induced transfer (PET) leads to the weak emission of BODIPY unit. When metal ions anchored with DPA, PET was blocked due to the weak electron donating ability of N in DPA to BODIPY and the highly emissive character of BODIPY was recovered, establishing a fluorescence switch. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,European Journal of Medicinal Chemistry included an article by Zhu, Zhenzhu; Yang, Tao; Zhang, Lei; Liu, Lulu; Yin, Enmao; Zhang, Changli; Guo, Zijian; Xu, Chen; Wang, Xiaoyong. SDS of cas: 1539-42-0. The article was titled 《Inhibiting Aβ toxicity in Alzheimer’s disease by a pyridine amine derivative》. The information in the text is summarized as follows:

Alzheimer’s disease (AD) is a neurodegenerative disorder with no radical therapy. Aggregation of amyloid β-peptide (Aβ) induced by various factors is associated with pathogenesis of AD. A pyridine amine derivative, 3-bis(pyridin-2-ylmethyl)aminomethyl-5-hydroxybenzyltriphenylphosphoniumbromide(PAT), is synthesized. The inhibition of self- and metal-induced Aβ aggregation by PAT is confirmed by thioflavine T fluorescence, CD spectroscopy, and TEM. Western blot, RT-PCR and fluorescence imaging indicate that PAT can alleviate the Aβ-induced paralysis, reduce the production of ROS, and protect the mitochondrial function in transgenic C. elegans. Genetic analyses indicate that heat shock protein is involved in the alleviation of Aβ toxicity. PAT also inhibits the activity of acetylcholinesterase in C. elegans. Morris water maze test shows that the memory and cognitive ability of APP/PS1 AD model mice are significantly improved by PAT. Both in vitro and in vivo studies demonstrate that PAT is effective in counteracting Aβ toxicity and ameliorating cognitive functions in AD mice, and therefore a potential lead compound of anti-AD drugs. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem