Category: 1539-42-0

《A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery》 was written by Ren, Lanfang; Lv, Jia; Wang, Hui; Cheng, Yiyun. Product Details of 1539-42-0 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Cytosolic protein delivery is a prerequisite for the development of protein therapeutics that act on intracellular targets. Proteins are generally membrane-impermeable and thus need a carrier such as a polymer to facilitate their internalization. However, the efficient binding of proteins with different isoelec. points to polymeric carriers is challenging. In this study, we designed a coordinative dendrimer to solve this problem. The dendrimers modified with dipicolylamine/zinc(II) complex were capable of binding proteins through a combination of ionic and coordination interactions. The best polymer efficiently delivered 30 cargo proteins and peptides into the cytosol, while maintaining their bioactivity after intracellular release. The removal or replacement of zinc ions in the polymer with other transition-metal ions lead to significantly decreased efficiency in cytosolic protein delivery. This study provides a new strategy to develop robust and efficient polymers for cytosolic protein delivery. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Madide, Thobeka; Somboro, Anou M.; Amoako, Daniel G.; Khumalo, Hezekiel M.; Khan, Rene B. published an article in 2021. The article was titled 《Di-2-picolylamine triggers caspase-independent apoptosis by inducing oxidative stress in human liver hepatocellular carcinoma cells》, and you may find the article in Biotechnology and Applied Biochemistry.Application of 1539-42-0 The information in the text is summarized as follows:

The basis of this study was to determine the effects of DPA on the proliferation and apoptosis of human hepatocellular carcinoma cells and elucidate the possible mechanisms. The methylthiazol tetrazolium assay served to measure cell viability and generated an IC50 of 1591μM. Luminometry was used to investigate caspase activity and ATP concentration It was observed that the decreased cell viability was associated with reduced ATP levels. Despite increased Bax and caspase 9 activity, cell death was caspase independent as indicated by the reduction in caspase 3/7 activity. This was associated with the downregulation poly(ADP-ribose) polymerase cleavage (Western blotting). However, the Hoescht assay depicted nuclear condensation and apoptotic body formation with elevated DPA levels suggesting DNA damage in HepG2 cells. DNA damage assessed by the comet assay confirmed an increased comet tail formation. The presence of oxidative stress was investigated by quantifying reactive species (malondialdehyde and nitrates concentration) and Western blotting to confirm the expression of antioxidant proteins. The DPA increased lipid peroxidation (RNS), a marker of oxidative stress, consequently causing cell death. The accompanying upregulation of stress-associated proteins superoxide dismutase (SOD2), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and Hsp70 verifies oxidative stress. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc Photocages with Improved Photophysical Properties and Cell Permeability Imparted by Ternary Complex Formation》 was written by Basa, Prem N.; Barr, Chelsea A.; Oakley, Kady M.; Liang, Xiaomeng; Burdette, Shawn C.. Application of 1539-42-0This research focused onzinc photocage photophys cell permeability ternary complex; crystal structure. The article conveys some information:

Photocaged complexes can control the availability of metal ions to interrogate cellular signaling pathways. The authors describe a new photocage, {bis[(2-pyridyl)methyl]amino}(9-oxo-2-xanthenyl)acetic acid (XDPAdeCage, 1), which utilizes a 2-xanthone acetic acid group to mediate a photodecarboxylation reaction. XDPAdeCage photolyzes with a quantum yield of 27%, and binds Zn2+ with 4.6 pM affinity, which decreases by over 4 orders of magnitude after photolysis. For comparison to the previous approach to Zn2+ release via photodecarboxylation, the analogous photocage {bis[(2-pyridyl)methyl]amino}(m-nitrophenyl)acetic acid (DPAdeCage, 2), which uses a m-nitrobenzyl chromophore, was also prepared and characterized. The advantages of the 2-xanthone acetic acid chromophore include red-shifted excitation and a higher extinction coefficient at the preferred uncaging wavelength. The neutral ternary complex of [Zn(XDPAdeCage)]+ with the anionic ligand pyrithione is membrane permeable, which circumvents the need to utilize invasive techniques to introduce intracellular Zn2+ fluctuations. Using fluorescent imaging, the authors have confirmed transport of Zn2+ across membranes; in addition, RT-PCR experiments demonstrate changes in expression of Zn2+-responsive proteins after photolysis. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization》 were Gandra, Upendar Reddy; Sinopoli, Alessandro; Moncho, Salvador; NandaKumar, Manjula; Ninkovic, Dragan B.; Zaric, Snezana D.; Sohail, Muhammad; Al-Meer, Saeed; Brothers, Edward N.; Mazloum, Nayef A.; Al-Hashimi, Mohammed; Bazzi, Hassan S.. And the article was published in ACS Applied Materials & Interfaces in 2019. Application of 1539-42-0 The author mentioned the following in the article:

Carbon monoxide (CO) is an important biol. gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clin. application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent d. functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ovchenkova, Ekaterina N.; Tsaturyan, Arshak A.; Bichan, Nataliya G.; Lomova, Tatyana N. published an article in 2021. The article was titled 《N Basicity of Substituted Fullero[60]/[70]pyrrolidines According to DFT/TD-DFT Calculations and Chemical Thermodynamics》, and you may find the article in Journal of Physical Chemistry A.Related Products of 1539-42-0 The information in the text is summarized as follows:

The basicity thermodn. parameters of pyridyl/imidazole-substituted fullero[60]/[70]pyrrolidines with respect to N heteroatoms in dichloromethane, which are necessary both to deepen insight into aromaticity “”neque levia”” and to create supramol. chem. structures for application, are obtained and discussed in this work. Because of the presence of a chromophore in the mols., the acid-base reactions of three C60 derivatives functionalized in different ways and one C70 derivative are studied using spectrophotometric titration with trifluoroacetic acid. The dependence of the pK values determined using the data on Hammett′s acidity functions, H0, for a binary nonaqueous solvent on the mol.′s chem. structure is shown. D. functional theory (DFT) and time-dependent DFT (TD-DFT) at the B3LYP/6-311G(d,p) level were used for the optimization of the fullerene derivative structures and modeling of their UV-vis spectra. The pKBH+ values of substituted fullero[60]/[70]pyrrolidines are predicted by quantum-chem. calculations After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《Degradation of organic dyes by water soluble iron(III) mononuclear complexes from bis-(2-pyridylmethyl)amine NNN-derivative ligands》 appeared in Inorganic Chemistry Communications. The author of the article were Carvalho, Samira S. F.; Carvalho, Nakedia M. F.. The article conveys some information:

This work describes the degradation of the dyes methyl orange (MO), methylene blue (MB), crystal violet (CV), Congo red (CR) and Rhodamine B (RhB), catalyzed by four water soluble mononuclear iron(III) complexes, in presence of hydrogen peroxide. The NNN ligands are bis-(2-pyridylmethyl)amine (BMPA) and three -derivatives: N-methylpropanoate-N,N-bis-(2-pyridylmethyl)amine (MPBMPA), N-propanoate-N,N-bis-(2-pyridylmethyl)amine (PBMPA), N-propanamide-N,N-bis-(2-pyridylmethyl)amine (PABMPA). More than 85% of degradation was achieved after 180 min for all dyes. The complex [Fe(MPBMPA)Cl3] was the most active. Kinetic experiments indicated a two-step reaction, where the intermediate Fe(III)-OOH is the catalytic species in the first step (k1), followed by the hydroxyl radical degradation in the second step (k2). The degradation percentage was well correlated with k2, being the degradation of the dye by the hydroxyl radical the most important step. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Quality Control of Bis(pyridin-2-ylmethyl)amine) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Quality Control of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pham, Thanh Chung; Kim, Hyun Sung; Lee, Songyi published an article in 2021. The article was titled 《Polydiacetylenes Functionalized with Chelidamic Acid and 2,2′-Dipicolylamine for Colorimetric Responses to Cadmium Ions》, and you may find the article in Bulletin of the Korean Chemical Society.Computed Properties of C12H13N3 The information in the text is summarized as follows:

A novel polydiacetylene-linked ligand derived from the reaction between chelidamic acid and bis(pyridin-2-ylmethyl)amine (PDA-CB) showed excellent selectivity and sensitivity for Cd2+ ions compared with other metal ions, including Zn2+. An obvious color change between PDA-CB and PDA-CB + Cd2+ is clearly visible to the naked eye. The Cd2+-responsive color change of PDA-CB is attributed to the coordination between Cd2+ and CB ligand units and has been characterized by 1H NMR titrationBis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Computed Properties of C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Computed Properties of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and characterization of new polyoctahedral silsesquioxanes containing zinc coordination compounds on the surface》 was written by Gomes, Marco Antonio G. B.; Pessanha, Quezia S. J.; Toledo, Rosane; Lube, Leonardo M.; Fernandes, Christiane; Horn, Adolfo Jr.. Electric Literature of C12H13N3 And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

The present work reports the synthesis and characterization of six new inorganic-organic hybrid materials containing Si8O12 (T8) or Si7O11H (T7) core built on polyoctahedral silsesquioxanes (POSS) backbone. To these units, tri-, penta- and hexadentate ligands containing N3, N4O and N5O coordinating sites were attached by reacting 3-(glycidyloxypropyl)trimethoxysilane (GPTMS) with primary/secondary amines followed self-condensation reaction, in basic medium. To prove that the ligands attached to the silicate backbone can bind metal ions, the materials were complexed with Zn(II) ions. The functionalized POSSs containing the ligands with N4O and N5O coordinating sites reacted with Zn(II) at 1:1 stoichiometric ratio. However, the reaction between the POSS containing the N3 ligand resulted in a stoichiometric ratio metal:ligand of 1:2. IR spectroscopy revealed the formation of siloxane cores. This feature was further confirmed by 29Si NMR, which is dominated by a signal around -67 ppm, typical of T3 sites. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Cesari, Andrea; Casulli, Maria Antonietta; Hashimoto, Takeshi; Hayashita, Takashi published an article in International Journal of Molecular Sciences. The title of the article was 《NMR Investigation of the Supramolecular Complex Formed by a Phenylboronic Acid-Ferrocene Electroactive Probe and Native or Derivatized β-Cyclodextrin》.Category: pyridine-derivatives The author mentioned the following in the article:

Specifically designed electrochem. sensors are standing out as alternatives to enzyme-based biosensors for the sensing of metabolites. In our previous works, we developed a new electrochem. assay based on cyclodextrin supramol. complexes. A ferrocene moiety (Fc) was chem. modified by phenylboronic acid (4-Fc-PB) and combined with two different kinds of cyclodextrins (CDs): β-CD and β-CD modified by a dipicolylamine group (dpa-p-HB-β-CDs) for the sensing of fructose and adenosine-triphosphate (ATP), resp. The aim of the present work is to better comprehend the features underlining the aforementioned complex formation. For the first time, a study about inclusion phenomena between the 4-Fc-PB electroactive probe with β-CD and with dpa-p-HB-β-CD was performed by using NMR (NMR) anal. In particular, we focused on providing insights on the interaction involved and on the calculation of the binding constant of 4-Fc-PB/β-CD supramol. complex, and elucidation about a drift in the time observed during the control experiments of the electrochem. measurements for the 4-Fc-PB/dpa-p-HB-β-CD supramol. complex. In this sense, this paper represents a step further in the explanation of the electrochem. results obtained, pointing out the nature of the interactions present both in the formation of the inclusions and in the sensing with the analytes. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Bispicolyamine-based supramolecular polymeric gels induced by distinct different driving forces with and without Zn2+》 was published in International Journal of Molecular Sciences in 2020. These research results belong to Park, Jaehyeon; Kim, Ka Young; Kang, Seok Gyu; Lee, Shim Sung; Lee, Ji Ha; Jung, Jong Hwa. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine The article mentions the following:

Metal-coordination polymeric gels are interesting areas as organic/inorganic hybrid supramol. materials. The bispicolylamine (BPA) based gelator (1) showed excellent gelation with typical fibrillar morphol. in acetonitrile. Upon complexing 1 with Zn2+, complexes ([1 + Zn + ACN]2+ and [1 + zinc trifluoromethanesulfonate (ZnOTf)]+) with four coordination numbers were formed, which determine the gel structure significantly. A gel-sol transition was induced, driven by the ratio of the two metal complexes produced. Through NMR anal., the driving forces in the gel formation (i.e., hydrogen-bonding and π-π stacking) were observed in detail. In the absence and the presence of Zn2+, the intermol. hydrogen-bonds and π-π stacking were the primary driving forces in the gel formation, resp. In addition, the supramol. gels exhibited a monolayer lamellar structure irresp. of Zn2+. Conclusively, the gels’ elasticity and viscosity reduced in the presence of Zn2+. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem