Category: 1539-42-0

The author of 《Fast Oxygen Reduction Catalyzed by a Copper(II) Tris(2-pyridylmethyl)amine Complex through a Stepwise Mechanism》 were Langerman, Michiel; Hetterscheid, Dennis G. H.. And the article was published in Angewandte Chemie, International Edition in 2019. Formula: C12H13N3 The author mentioned the following in the article:

Catalytic pathways for the reduction of dioxygen can either give H2O or peroxide as the reaction product. The electrocatalytic reduction of O2 by the pyridylalkylamine Cu complex [Cu(tmpa)(L)]2+ in a neutral aqueous solution follows a stepwise 4 e-/4 H+ pathway, in which H2O2 is formed as a detectable intermediate and subsequently reduced to H2O in two sep. catalytic reactions. These homogeneous catalytic reactions are 1st order in catalyst. Coordination of O2 to CuI is the rate-determining step in the formation of the peroxide intermediate. Also, electrochem. studies of the reaction kinetics revealed a high turnover frequency of 1.5 × 105 s-1, the highest reported for any mol. Cu catalyst. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattacharyya, Arnab; Jameei, Aida; Karande, Anjali A.; Chakravarty, Akhil R. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《BODIPY-attached zinc(II) complexes of curcumin drug for visible light assisted photo-sensitization, cellular imaging and targeted PDT》.Quality Control of Bis(pyridin-2-ylmethyl)amine The article contains the following contents:

Boron-dipyrromethene (BODIPY) based photosensitizers as porphyrinoids and curcumin as natural product possess exciting photophys. features suitable for theranostic applications, namely, imaging and photodynamic therapy (PDT). Limited aqueous solubility and insufficient physiol. stability, however, reduce their efficacy significantly. We have designed a novel strategy to deliver these two unusable cytotoxins simultaneously in cancer cells and herein, report the synthesis, characterization and imaging-assisted photocytotoxicity of three zinc(II) complexes containing N3-donor dipicolylamine (dpa) ligands (L1-3) and O,O-donor curcumin (Hcur) viz. [Zn(L1)(cur)]Cl (1), [Zn(L2)(cur)]Cl (2) and [Zn(L3)(cur)]Cl (3), where L2 and L3 have pendant fluorescent BODIPY and non-emissive di-iodo-BODIPY moieties. Metal chelation imparted remarkable biol. stability (pH ∼7.4) to the resp. ligands and induces significant aqueous solubility These ternary complexes could act as replacements of the existing metalloporphyrin-based PDT photosensitizers as their visible-light photosensitizing ability is reinforced by the dual presence of blue light absorbing curcumin and green light harvesting BODIPY units. Complex 2 having emissive BODIPY unit L2 and curcumin, showed mitochondria selective localization in HeLa, MCF-7 cancer cells and complex 3, the di-iodinated analog of complex 2, exhibited type-I/II PDT activity via inducing apoptosis through mitochondrial membrane disruption in cancer cells while being significantly nontoxic in dark and to the healthy cells. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Quality Control of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Quality Control of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《Synthetic Polymers To Promote Cooperative Cu Activity for O2 Activation: Poly vs. Mono》 was published in Journal of the American Chemical Society. The article was written by Thanneeru, Srinivas; Milazzo, Nicholas; Lopes, Aaron; Wei, Zichao; Angeles-Boza, Alfredo M.; He, Jie. The article contains the following contents:

The authors report polymer-promoted cooperative catalysis of Cu for O activation. Random copolymers containing dipicolylamine as binding motifs are designed to coordinate type-3 Cu sites. The Cu-copolymers show a 6-8-fold activity enhancement, compared to the mol. complex of Cu with an identical coordination site. Michaelis-Menten anal. demonstrates that the kinetic enhancement results from flexible polymer-promoted cooperative catalysis among multi-Cu sites despite the imposed thermodn. barrier. These observations provide guidance for the bioinspired design of metallopolymers as soluble catalysts with high activity. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Safety of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Safety of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Simultaneous Fluorescence Imaging Reveals N-Methyl-D-aspartic Acid Receptor Dependent Zn2+/H+ Flux in the Brains of Mice with Depression》 was written by Wang, Xin; Bai, Xiaoyi; Su, Di; Zhang, Yandi; Li, Ping; Lu, Shuyi; Gong, Yulin; Zhang, Wen; Tang, Bo. Category: pyridine-derivatives And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020. The article conveys some information:

Depression is immensely attributed to the overactivation of N-methyl-D-aspartic acid (NMDA) receptor in the brains. As regulatory binding partners of NMDA receptor, both Zn2+ and H+ are intimately interrelated to NMDA receptor’s activity. Therefore, exploring synergistic changes on the levels of Zn2+ and H+ in brains will promote the knowledge and treatment of depression. However, the lack of efficient, appropriate imaging tools limits simultaneously tracking Zn2+ and H+ in living mouse brains. Thus, a well-designed dual-color fluorescent probe (DNP) was fabricated for the simultaneous monitoring of Zn2+ and H+ in the brains of mice with depression. Encountering Zn2+, the probe evoked bright blue fluorescence at 460 nm. Meanwhile, the red fluorescence at 680 nm was decreased with H+ addition With blue/red dual fluorescence signal of DNP, we observed the synchronous increased Zn2+ and H+ in PC12 cells under oxidative stress. Notably, in vivo imaging for the first time revealed the simultaneous reduction of Zn2+ and pH in brains of mice with depression-like behaviors. Further results implied that the NMDA receptor might be responsible for the coinstantaneous fluctuation of Zn2+ and H+ during depression. Altogether, this work is conducive to the knowledge of neural signal transduction mechanisms, advancing our understanding of the pathogenesis in depression. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Imaging and therapeutic applications of Zn(II)-cryptolepine-curcumin molecular probes in cell apoptosis detection and photodynamic therapy》 was written by Qin, Qi-Pin; Wei, Zu-Zhuang; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Zou, Hua-Hong; Liang, Hong. Electric Literature of C12H13N3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Novel red Zn(II) complex-based fluorescent probes featuring cryptolepine-curcumin derivatives, namely, [Zn(BQ)Cl2] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biol. process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Fluorescence Lifetime Imaging of p-tau Protein in Single Neuron with a Highly Selective Fluorescent Probe》 were Ge, Lihong; Tian, Yang. And the article was published in Analytical Chemistry (Washington, DC, United States) in 2019. HPLC of Formula: 1539-42-0 The author mentioned the following in the article:

Hyperphosphorylated tau (p-tau) protein is one of the key markers of Alzheimer’s disease (AD). However, a lack of anal. methods for p-tau protein with high selectivity and accuracy is the bottleneck to understand the pathol. processes of AD. In the present work, a highly selective fluorescence lifetime imaging microscopic (FLIM) probe (τ-p-tau) was rationally designed and developed for determination of p-tau protein, in which binuclear zinc units were designed as the recognition groups, and an improved cyanine was synthesized as the dye unit. The FLIM measurement is independent of the concentration of fluorescent probes, irradiation light sources, and measurement environments. Meanwhile, the developed τ-p-tau probe demonstrated strong affinity toward p-tau protein, thus enhancing the selectivity of determination of p-tau protein against Aβ, Aβ fibril, tau, protein kinases, ATP, and so on. The fluorescence lifetime of τ-p-tau probe showed a good linearity with the concentration of p-tau protein from 1.0 to 5.0 μM with a low detection limit of 85.15±0.03 nM. The response time of the present probe for p-tau protein was estimated to be less than 6.2 s. Furthermore, taking the advantages of low toxicity and good biocompatibility, the developed probe was successfully applied to monitor the fluctuation of concentration of p-tau protein by FLIM imaging at single neuron level. It was found that the concentration of p-tau protein inside live neurons obviously changed upon oxidative stress. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Bis(pyridin-2-ylmethyl)amineIn 2021 ,《Design of 99mTc-labeled zinc-chelating imaging probe for SPECT imaging of the pancreas》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Eeda, Venkateswararao; Hedrick, Andria; Awasthi, Vibhudutta. The article contains the following contents:

Early and sensitive diagnosis of pancreatic diseases is a contemporary clin. challenge. Zinc level in pancreatic tissue and its secretion in pancreatic juice has long been considered a surrogate marker of pancreatic function. The objective of this study was to design a Zn-chelating imaging probe (ZCIP) which could be labeled with 99mTc radionuclide for imaging of pancreas using single photon emission tomog. (SPECT). We synthesized ZCIP as a bifunctional chelate consisting of diethylene triamine pentaacetic acid for 99mTc-chelation at one end and bispicolylethylamine for Zn-complexation at the other end. ZCIP was labeled with 99mTc by standard Sn2+-based reduction method. The 99mTc-labeled ZCIP was studied in normal mice (0.3 mCi) for SPECT imaging. We found that ZCIP consistently labeled with 99mTc radionuclide with over 95% efficiency. Addition of ZCIP altered the spectrum of standard dithizone-Zn complex, indicating its ability to chelate Zn. SPECT data demonstrated the ability of 99mTc-ZCIP to image pancreas with high sensitivity in a non-invasive manner; liver and spleen were the other major organs of 99mTc-ZCIP uptake. Based on these results, we conclude that 99mTc-ZCIP presents as a novel radiotracer for pancreas imaging for diagnosis of diseases such as pancreatitis. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Synthesis of Novel Pseudocloso Ruthenacarboranes based on an Unsubstituted nido-C2B9H112- Ligand》 was published in European Journal of Inorganic Chemistry. The article was written by Kaltenberg, Alexander A.; Somov, Nikolay V.; Malysheva, Yulia B.; Vorozhtsov, Dmitry L.; Grishin, Ivan D.. The article contains the following contents:

The reaction of the known closo-ruthenacarborane 3-H-3-Cl-3,3-(PPh3)2-closo-3,1,2-RuC2B9H11 with tridentate nitrogen-based bis(pyridylmethyl)amine ligands of the general formula (2-C5H4NCH2)2NR (R = H, Me, Et, iPr, tBu) in benzene solution at 60° allowed us to isolate novel ruthenacarborane clusters 3,3,3-[(2′-NC5H4CH2)2NR]-pseudocloso-3,1,2-RuC2B9H11. According to the performed X-ray study, the obtained compounds are the first examples of pseudocloso-metallacarboranes bearing unsubstituted C2B92-nido-carborane ligand. In spite of the determined pseudocloso structure of the complexes in the solid state, the recorded 11B{1H} NMR spectra indicate that some of them are converted into the closo isomers in solution The conducted quantum-chem. calculations have confirmed the subtle difference between two configurations and possible rearrangement in solution The performed electrochem. investigations show the ability of the formed ruthenacarboranes to undergo reversible oxidation to Ru(III) species. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Xia, Wu; Ren, Ying-Yi; Liu, Jing; Deng, Bo-Yi; Wang, Feng published an article in Journal of Photochemistry and Photobiology, A: Chemistry. The title of the article was 《Non-synergistic photocatalysis of CO2-to-CO conversion by a binuclear complex of rigidly linking two cobalt catalytic centers》.COA of Formula: C12H13N3 The author mentioned the following in the article:

A novel binuclear cobalt complex C1 of rigidly linking two [Co(TPA)Cl]Cl moieties at meta positions of a benzene was synthesized and characterized as a catalyst for homogeneous photocatalytic CO2 reduction Different from state-of-the-art binuclear catalyst catalyzing CO2 reduction with a synergistic catalysis mechanism, C1 catalyzes CO2-to-CO conversion independently at each cobalt catalytic center. At an optimal condition, system of C1 produced CO with a TON of 721 (based on C1, corrsoponding to TON 360 per cobalt center) and a high selectivity of 91.5%. Electrochem. and steady state spectroscopy studies revealed that a CoICoI species, generated via successive photoinduced electron transfer from excited photosensitizer to C1, is the active species of CO2 conversion. No synergistic effect of two cobalt centers exists for CO2 reduction because of larger Co-Co distance and rigid structure of C1. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Highly efficient and selective photocatalytic CO2 to CO conversion in aqueous solution》 was written by Chai, Xiaomin; Huang, Hai-Hua; Liu, Huiping; Ke, Zhuofeng; Yong, Wen-Wen; Zhang, Ming-Tian; Cheng, Yuan-Sheng; Wei, Xian-Wen; Zhang, Liyan; Yuan, Guozan. Reference of Bis(pyridin-2-ylmethyl)amine And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Five mol. complexes with different non-noble metal centers were synthesized. The Co-based complex displays the highest photocatalytic performance for CO2 to CO conversion in aqueous media. It achieves high activity (TON = 41 017 and TOF = 3.80 s-1) and selectivity (87%) for the production of CO. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem