Category: 15420-02-7

Hou, Gui-Ge et al. published their research in CrystEngComm in 2010 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 15420-02-7

Co-crystallization of oxadiazole-bridged pyridyl-N-oxide building modules with R-aromatics (R = -OH, -NH2 and -COOH) was written by Hou, Gui-Ge;Ma, Jian-Ping;Wang, Le;Wang, Ping;Dong, Yu-Bin;Huang, Ru-Qi. And the article was included in CrystEngComm in 2010.Application of 15420-02-7 This article mentions the following:

The reaction of oxadiazole bridging pyridyl-N-oxides (2,5-bis(4-pyridyl-N-oxide)-1,3,4-oxadiazole (A1) and 2-(4-pyridyl)-5-(4-pyridyl-N-oxide)-1,3,4-oxadiazole (A2)) with different substituted aromatics (R-aromatics, R = -OH, -NH2, -COOH) were studied. Eight new organic co-crystals of 1-8 were synthesized and characterized by elemental anal., FTIR spectroscopy, 1H NMR and single-crystal x-ray diffraction. The results display the distinct substituent effect on the hydrogen-bonded self-assembly systems. The luminescent properties of A1-A2 and 1-8 were studied in the solid state. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Application of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fang, Zhenlan et al. published their research in CrystEngComm in 2012 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C12H8N4O

Solvothermal synthesis of two new coordination polymers: in situ heterocycle conversion and N-alkylation, network topologies and luminescence properties was written by Fang, Zhenlan;Yang, Wenbin;He, Jiangang;Ding, Kaining;Wu, Xiaoyuan;Zhang, Qisheng;Yu, Rongmin;Lu, Canzhong. And the article was included in CrystEngComm in 2012.COA of Formula: C12H8N4O This article mentions the following:

Two new copper complexes [CuI4(L2)I5]n (1, L2 = 3,5-bis(1-ethylpyridinium-4-yl)-1,2,4-triazol-4-ide) and [CuI6(L3)3Br3]n (2, L3 = 3,5-bis(4-pyridyl)-1,2,4-triazolate) were obtained from the solvothermal reactions of different copper halides with 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (L1) in the presence of aqueous ammonia. The x-ray diffraction, IR spectrum and elemental analyses of 1 and 2 clearly show that the 1,3,4-oxadiazole ligand L1 has transformed into the triazolate ligands L2 and L3. Most fascinatingly, 1 represents the first example of an integrated reaction system involving heterocyclic conversion from oxadiazole to triazolate, N-alkylation, and further self-assembly of the in situ generated ligand L2 with metal cations to form a coordination polymer in one solvothermal spot. The possible formation mechanism of 1 is proposed, and in addition, the interesting topologies and luminescence properties of 2 were studied based on the results of the DFT calculations In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7COA of Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bentiss, Fouad et al. published their research in Synthetic Communications in 2001 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 15420-02-7

Rapid synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under microwave irradiation was written by Bentiss, Fouad;Lagrenee, Michel;Barbry, Didier. And the article was included in Synthetic Communications in 2001.Recommanded Product: 15420-02-7 This article mentions the following:

A number of sym. 2,5-disubstituted 1,3,4-oxadiazoles I (Ar = Ph, 2-ClC6H4, 4-pyridyl, etc.) are quickly prepared by the reaction of aromatic acids ArCO2H with hydrazine dihydrochloride in a mixture of orthophosphoric acid and phosphorus pentoxide under microwave irradiation In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhoufal, Ferdaousse et al. published their research in Acta Crystallographica, Section E: Crystallographic Communications in 2019 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Crystal structure, spectroscopic characterization and Hirshfeld surface analysis of trans-diaqua[2,5-bis(pyridin-4-yl)-1,3,4-oxadiazole]dithiocyanatonickel(II) was written by Rhoufal, Ferdaousse;Bentiss, Fouad;Guesmi, Salaheddine;Ketatni, El Mostafa;Saadi, Mohamed;El Ammari, Lahcen. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2019.Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

The reaction of 2,5-bis(pyridin-4-yl)-1,3,4-oxadiazole (4-pox) and thiocyanate ions, used as co-ligand with nickel salt NiCl2·6H2O, produced the title complex, [Ni(NCS)2(C12H8N4O)2(H2O)2]. The NiII atom is located on an inversion center and is octahedrally coordinated by four N atoms from two ligands and two pseudohalide ions, forming the equatorial plane. The axial positions are occupied by two O atoms of coordinated water mols. In the crystal, the mols. are linked into a three-dimensional network through strong O-H···N hydrogen bonds. Hirshfeld surface anal. was used to investigate the intermol. interactions in the crystal packing. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sagitullin, R. S. et al. published their research in Vestnik Moskovskogo Universiteta, Seriya Matematiki, Mekhaniki, Astronomii, Fiziki, Khimii in 1959 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Reactions of the hydrazine derivatives. XXV. Action of acetic anhydride and polyphosphoric acid on acylhydra-zones was written by Sagitullin, R. S.;Kost, A. N.. And the article was included in Vestnik Moskovskogo Universiteta, Seriya Matematiki, Mekhaniki, Astronomii, Fiziki, Khimii in 1959.Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

In the interaction of various acylhydrazones (containing the NH group) with Ac2O, independent of the structure of the acyl residue and the carbonyl components (acetone, cyclohexanone, or benzaldehyde), cyclization took place to yield N-acetyl-oxadiazolines. Under the action of polyphosphoric acid (I) as condensing agent, disproportionation, with the formation of diacylhydrazine and azine, took place; the diacylhydrazine, under the conditions of reaction, separated H2O to give an oxadiazole. Acetone acetylhydrazone (II) (50 g.) and 60 ml. Ac2O was refluxed 45 min., cooled, 100 ml. H2O added, the mixture neutralized with KOH, the oil separated, the aqueous layer extracted twice with Et2O, the combined extracts dried over KOH, the Et2O evaporated, and the residue distilled to yield 70% 2,2,5-trimethyl-3-acetyl-1,3,4-oxadiazoline, b18 88-90°, m. 23-4°, n20D 1.4627, d20 1.0547, MRD 40.75. Cyclohexanone acetylhydrazone, m. 124° (alc.), (2 g.) and 2.5 g. Ac2O was refluxed 1 hr., cooled, 30 ml. H2O added, the mixture neutralized with KOH, and the oil cooled with ice water to yield 51% 5-methyl-2,2-pentamethylene-3-acetyl-1,3,4-oxadiazoline, m. 63-5° (petr. ether). In an analogous manner, 3.5 g. benzaldehyde acetylhydrazone and 7 g. Ac2O was boiled 40 min. to yield 80% 5-methyl-2-phenyl-3-acetyl-1,3,4-oxadiazoline, m. 90-2° (alc.). Acetone benzoylhydrazone (2.5 g.) and 3 g. Ac2O yielded 83% 5,5-dimethyl-2-phenyl-3-acetyl-1,3,4-oxadiazoline, m. 49-50° (petr. ether), λ 292, 305 mμ, log ε 4.176, 4.041. Cyclohexanone benzoylhydrazone (2.5 g.) and 3.3 g. Ac2O yielded (30 min. boiling) 84% 5-phenyl-2,2-pentamethylene-3-acetyl-1,3,4-oxadiazoline, m. 79-80 (petr. ether). Benzaldehyde benzoylhydrazone (15 g.) and 30 g. Ac2O boiled 40 min. yielded 94% 2,5-diphenyl-3-acetyl-1,3,4-oxadiazoline, m. 92-4° (aqueous alc.), λ 290 mμ, log ε 4.16. Cyclohexanone isonicotinoylhydrazone (1 g.) and 2 g. Ac2O yielded 84% 3-acetyl-5-(4-pyridyl)-2,2-pentamethylene-1,3,4-oxadiazoline, m. 104-5°. II (50 g.) and 100 g. I heated 1 hr. at 150-60°, while stirring occasionally the mixture dissolved in 200 ml. H2O, saturated with KOH, the upper oily layer separated, dried thoroughly over KOH, and distilled yielded 82% 3,5,5-trimethylpyrazoline, m. 158-63°; HCl salt m. 168-71°. Acetone benzoylhydrazone (4.5 g.) and 17 g. I was heated 1 hr. at 180-90°, cooled, and poured into cold H2O to yield quant. 2,5-diphenyl-1,3,4-oxadiazole, m. 138-39°, λ 280 mμ, log ε 4.43; traces only of 3,5,5-trimethylpyrazoline were found in the filtrate. In an analogous manner, 15 g. cyclohexanone benzoylhydrazone and 45 g. I boiled 1 hr. at 140-50° yielded 65% 2,5-diphenyl-1,3,4-oxadiazole, m. 137.5-8°; the aqueous solution after the separation of the oxadiazole was neutralized with KOH, extracted with Et2O, the Et2O layer dried over KOH, and Et2O evaporated to yield 1.5 g. cyclohexanone azine, b7 140-3°. Acetone isonicotinoylhydrazone (2.1 g.) and 11 g. I kept 2 hrs. at 170-80° yielded 42% 2,5-di(4-pyridyl)-1,3,4-oxadiazole, m. 185-6° (MeOH). In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Shuang et al. published their research in Dalton Transactions in 2006 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 15420-02-7

Synthesis and characterization of binuclear half-sandwich metal (Co, Ir and Ru) complexes containing ancillary ortho-carborane-1,2-dithiolato ligands was written by Liu, Shuang;Zhang, Jiasheng;Wang, Xin;Jin, Guo-Xin. And the article was included in Dalton Transactions in 2006.HPLC of Formula: 15420-02-7 This article mentions the following:

Pyrazine-, 4,4′-bipyridine-, 1,2-ethenediylbis-4,4′-pyridine-, 2,5-bis(4-pyridinyl)-1,3,4-oxadiazole-bridged binuclear half-sandwich Co, Ir and Ru o-carborane-1,2-dithiolates were prepared by reacting of the corresponding monomeric η5-C5Me5– (for Co and Ir) and η6-p-cymene (for Ru) dithiolates with the heterocyclic bidentate ligands. The prepared complexes are soluble and air-stable. The complexes [[(p-cymene)Ru[S2C2(B10H10)]]2(μ-pyrazine-κN1κN4)] (4), [[Cp*Co[S2C2(B10H10)]]2(μ-pyrazine-κN1κN4)] (5), [[Cp*Co[S2C2(B10H10)]]2(μ-4,4′-bipyridine)] (6), [Cp*Co[S2C2(B10H10)]]2(μ-bpe) (7, bpe = 4-C5H4NCH:CHC5H4N-4) and [[Cp*Ir[E2C2(B10H10)]]2(μ-bpo)] [8a,b; E = S, Se; bpo = 2,5-bis(4-pyridinyl-κN)-1,3,4-oxadiazole], in which organometallic units are bridged by pyridyl-based organic linkers, were prepared The crystal structures of 4, 5, 6, 7 and 8 are reported. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7HPLC of Formula: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Shuang et al. published their research in Dalton Transactions in 2006 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 15420-02-7

Synthesis and characterization of binuclear half-sandwich metal (Co, Ir and Ru) complexes containing ancillary ortho-carborane-1,2-dithiolato ligands was written by Liu, Shuang;Zhang, Jiasheng;Wang, Xin;Jin, Guo-Xin. And the article was included in Dalton Transactions in 2006.HPLC of Formula: 15420-02-7 This article mentions the following:

Pyrazine-, 4,4′-bipyridine-, 1,2-ethenediylbis-4,4′-pyridine-, 2,5-bis(4-pyridinyl)-1,3,4-oxadiazole-bridged binuclear half-sandwich Co, Ir and Ru o-carborane-1,2-dithiolates were prepared by reacting of the corresponding monomeric η5-C5Me5– (for Co and Ir) and η6-p-cymene (for Ru) dithiolates with the heterocyclic bidentate ligands. The prepared complexes are soluble and air-stable. The complexes [[(p-cymene)Ru[S2C2(B10H10)]]2(μ-pyrazine-κN1κN4)] (4), [[Cp*Co[S2C2(B10H10)]]2(μ-pyrazine-κN1κN4)] (5), [[Cp*Co[S2C2(B10H10)]]2(μ-4,4′-bipyridine)] (6), [Cp*Co[S2C2(B10H10)]]2(μ-bpe) (7, bpe = 4-C5H4NCH:CHC5H4N-4) and [[Cp*Ir[E2C2(B10H10)]]2(μ-bpo)] [8a,b; E = S, Se; bpo = 2,5-bis(4-pyridinyl-κN)-1,3,4-oxadiazole], in which organometallic units are bridged by pyridyl-based organic linkers, were prepared The crystal structures of 4, 5, 6, 7 and 8 are reported. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7HPLC of Formula: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem