Category: 154237-70-4

Related Products of 154237-70-4, Adding some certain compound to certain chemical reactions, such as: 154237-70-4, name is 4-Bromo-3-cyanopyridine,molecular formula is C6H3BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154237-70-4.

Step 3, Method 15: 4-[5-(2-Fluoroethoxy)-l-benzofuran-2-yl]pyridine-3- carbonitrile[0204] To a stirred solution of [5-(2-fluoroethoxy)-l-benzofuran-2-yl]boronic acid (120 mg, 0.54 mmol) and 4-bromo-3-cyanopyridine (98 mg, 0.54 mmol) in 1,4- dioxane (3 mL) under nitrogen were added copper(I) iodide (10 mg, 0.054 mmol), caesium fluoride (163 mg, 1.07 mmol) and tetrakis(triphenylphosphine)palladium(0) (31 mg, 0.027 mmol). The reaction mixture was degassed using a stream of nitrogen for 10 minutes then heated under a nitrogen atmosphere to 60 C and stirred for 18 hours. The mixture was concentrated, ethyl acetate (10 mL) and water (10 mL) added and the layers separated. The organic layer was washed with water (2 x 10 mL), brine (2 x 10 mL), dried over magnesium sulphate, filtered and concentrated. Purification by FCC (silica, 0-30% ethyl acetate in heptane) and recrystallisation from heptane- dichloromethane (5:2) gave the title compound 46 mg (30% yield) as a yellow solid. Example 1, Method 15: 4-[5-(2-Fluoroethoxy)-l-benzofuran-2-yl]pyridine-3- carbonitrile[0205] 5H MR (500 MHz, DMSO) 9.11 (s, 1H), 8.92 (d, J= 5.4 Hz, 1H), 8.07 (d, J = 5.4 Hz, 1H), 7.93 (s, 1H), 7.64 (d, J= 9.0 Hz, 1H), 7.40 (d, J= 2.4 Hz, 1H), 7.13 (dd, J= 9.0, 2.5 Hz, 1H), 4.78 (dt, J = 47.9, 3.8 Hz, 2H), 4.30 (dt, J = 30.1, 3.7 Hz, 2H). Tr(MET-uHPLC-AB-lOl) = 3.21 min, (ES+) (M+H)+283.

According to the analysis of related databases, 154237-70-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHDI FOUNDATION, INC.; DOMINGUEZ, Celia; WITYAK, John; BARD, Jonathan; BROWN, Christopher, John; PRIME, Michael, Edward; WEDDELL, Derek, Alexander; WALTER, Daryl, Simon; GILES, Paul, Richard; WIGGINTON, Ian, James; TAYLOR, Malcolm, George; GALAN, Sebastien, Rene, Gabriel; JOHNSON, Peter, David; KRUeLLE, Thomas, Martin; MORAO, Inaki; CLARK-FREW, Daniel; SCHAERTL, Sabine; HERRMANN, Frank; GRIMM, Steffen, Kaspar; KAHMANN, Jan, Dirk; SCHEICH, Christoph; (120 pag.)WO2016/33460; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 154237-70-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 154237-70-4, name is 4-Bromo-3-cyanopyridine. A new synthetic method of this compound is introduced below.

3-Cyano-4-(phenylethynyl)pyridine (35). Copper(l) iodide (9.6 mg, 0.05 mmol), bis- (triphenylphosphine)palladium(ll) dichloride (29 mg, 0.025 mmol) and sodium ascorbate (9.9 mg, 0.05 mmol) were placed in a flask, which was degassed and filled with argon. Triethylamine (5.0 mL) was added, followed by 4-bromo-3-cyanopyridine 34 (92 mg, 0.5 mmol) in tetrahydrofuran (5.0 mL). The mixture was stirred at 40C for 30 min. Phenylethyne (76.5 mg, 0.75 mmol) was added and the mixture was stirred at 40C for 10 h. Evaporation and chromatography (petroleum ether / ethyl acetate 3: 1) gave 3-cyano-4-(phenylethynyl)pyridine 35 (80 mg, 78%) as an off-white powder: mp 74-75C (lit.91 85-87C); IR vmax 2222 (C?N), 2150 (C?C), 1582 (C=CAr), 1495 (C=N) cm”1; 1H NMR (CDCI3) delta 7.39-7.43 (3 H, m, Ph 3,4,5-H3), 7.45 (1 H, d, J = 5.2 Hz, 5-H), 7.63 (2 H, d, J = 8.2 Hz, Ph 2,6-H2), 8.75 (1 H, d, J = 5.2 Hz, 6-H), 8.87 (1 H, s, 2-H); 13C NMR (CDCI3) (HSQC / HMBC) delta 83.50 (ethyne 2-C), 101.29 (ethyne 1-C), 1 1.74 (4-C), 1 15.54 (C?N), 120.76 (Ph 1-C), 125.06 (5-C), 128.59 (Ph 3,5-C2), 130.28 (Ph 4- C), 132.38 (Ph 2,6-C2), 134.87 (3-C), 152.40 (2-C), 152.68 (6-C); MS m/z 227.0569 (M + Na)+ (C14H8N2Na requires 227.0585).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,154237-70-4, its application will become more common.

Reference:
Patent; UNIVERSITY OF BATH; THREADGILL, Michael David; LLOYD, Matthew David; THOMPSON, Andrew Spencer; NATHUBHAI, Amit; WOOD, Pauline Joy; PAINE, Helen Angharad; KUMPAN, Ekaterina; SUNDERLAND, Peter Thomas; CHUE YEN WOON, Esther; WO2014/87165; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 154237-70-4, 4-Bromo-3-cyanopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H3BrN2, blongs to pyridine-derivatives compound. Computed Properties of C6H3BrN2

Into a 20 mL vial were added dimethylamine (295.63 mg, 6.557 mmol, 2.00 equiv) , 4-bromopyridine-3-carbonitrile (600 mg, 3.279 mmol, 1 equiv) and K 2CO 3 (1.36 g, 9.836 mmol, 3.00 equiv) at room temperature. The resulting mixture was stirred for 2 h at 40. The resulting mixture was filtered, the filter cake was washed with DCM (2×20 mL) . The filtrate was concentrated under reduced pressure. The residue was purified by Prep-TLC (EtOAc) to afford 4- (dimethylamino) pyridine-3-carbonitrile (470mg, 97.40%) as an off-white solid (crude) . 1H-NMR (400 MHz, CDCl 3) delta 3.26 (6H, s) , 6.55 (1H, d) , 8.23 (1H, d) , 8.47 (1H, s)

The synthetic route of 154237-70-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.; QI, Changhe; TSUI, Honchung; ZENG, Qingbei; YANG, Zhenfan; ZHANG, Xiaolin; (399 pag.)WO2020/35052; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem