Category: 15506-18-0

Some scientific research about 1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

The chemical industry reduces the impact on the environment during synthesis 15506-18-0, I believe this compound will play a more active role in future production and life.

Reference of 15506-18-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15506-18-0, name is 1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C7H7NO3, molecular weight is 153.1354, as common compound, the synthetic route is as follows.

b) 3-({9-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)methyl]-3,9- diazaspiro[5.5]undec-3-yl}carbonyl)-1-methylpyridin-2(lH)-oneN-methyl-2-hydroxynicotinic acid (45 mg, 0.29 mmol), Intermediate A (76 mg, 0.24 mmol), HATU (91.9 mg, 0.24 mmol) and triethylamine (43 mg, 0.43 mmol) in CH2Cl2 (4 mL) were mixed and stirred for Ih. The reaction mixture was diluted with saturated aqueous sodium carbonate (2 mL) and the product was extracted with dichloromethane and dried. The pure title compound was obtained by preparative HPLC.1H NMR (399.99 MHz, CD3OD) delta 7.81-7.71 (m, IH), 7.60-7.52 (m, IH), 7.32-7.26 (m, IH), 7.23-7.16 (m, IH), 6.97-6.88 (m, IH), 6.48-6.36 (m, IH), 4.32-4.19 (m, 2H), 3.79- 3.67 (m, 2H), 3.62-3.55 (m, 3H), 3.45-3.35 (m, 2H), 3.26-3.06 (m, 4H), 2.08-1.96 (m, 2H), 1.84-1.37 (m, 14H)APCI-MS m/z: 450.5 [MH+]HPLC (Method A) Retention time: 5.63 minHPLC (Method B) Retention time: 7.07 min

The chemical industry reduces the impact on the environment during synthesis 15506-18-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; WO2007/30061; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

The chemical industry reduces the impact on the environment during synthesis 15506-18-0, I believe this compound will play a more active role in future production and life.

Application of 15506-18-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15506-18-0, name is 1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C7H7NO3, molecular weight is 153.1354, as common compound, the synthetic route is as follows.

b) 3-({9-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)methyl]-3,9- diazaspiro[5.5]undec-3-yl}carbonyl)-1-methylpyridin-2(lH)-oneN-methyl-2-hydroxynicotinic acid (45 mg, 0.29 mmol), Intermediate A (76 mg, 0.24 mmol), HATU (91.9 mg, 0.24 mmol) and triethylamine (43 mg, 0.43 mmol) in CH2Cl2 (4 mL) were mixed and stirred for Ih. The reaction mixture was diluted with saturated aqueous sodium carbonate (2 mL) and the product was extracted with dichloromethane and dried. The pure title compound was obtained by preparative HPLC.1H NMR (399.99 MHz, CD3OD) delta 7.81-7.71 (m, IH), 7.60-7.52 (m, IH), 7.32-7.26 (m, IH), 7.23-7.16 (m, IH), 6.97-6.88 (m, IH), 6.48-6.36 (m, IH), 4.32-4.19 (m, 2H), 3.79- 3.67 (m, 2H), 3.62-3.55 (m, 3H), 3.45-3.35 (m, 2H), 3.26-3.06 (m, 4H), 2.08-1.96 (m, 2H), 1.84-1.37 (m, 14H)APCI-MS m/z: 450.5 [MH+]HPLC (Method A) Retention time: 5.63 minHPLC (Method B) Retention time: 7.07 min

The chemical industry reduces the impact on the environment during synthesis 15506-18-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; WO2007/30061; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 15506-18-0

The synthetic route of 15506-18-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 15506-18-0, 1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

[0625] To a solution of 2-(4-(2,4-difluorophenoxy)piperidin-l-yl)-5- (etaiotaomicronphi1etaomicron8Homicronetanu1)rhonupieta-3-3etapietaepsilon (50.00 mg, 1 10.0 muiotaetaomicron, 1.00 eq) and 1 -methyl -2 -oxo- 1,2- dihydropyridine-3-carboxylic acid (20.22 mg, 132.0 mutauetaomicron, 1.20 eq) in DMF (2 mL) was added HATU (62.75 mg, 165,02 muiotaetaomicron, 1.50 eq) and DIPEA (42.65 mg, 330.0 muetaiotaomicron, 57.64 mu,, 3.00 eq). The resulting mixture was stirred at 25C for 12 hours, then diluted with EtOAc (50 mL) and washed with saturated aq N’a >(*<) > (20 rnL) and brine (20 mL). The organic layers were dried over anhydrous NazSC filtered, concentrated in vacuo, and purified by preparative HPLC (basic mode) to give the title compound as a white solid (18 mg, 27%). .H NMR (400 MHz, CDCb) delta ppm 2.09 – 2.27 (m, 4 H), 3.01 – 3.15 (m, 4 H), 3.15 – 3.24 (m, 2 H), 3.54 – 3.63 (m, 2 H), 3.72 (s, 3 H), 3.75 – 3.85 (m, 4 H), 4.42 (dt,./ 7. 1. 3.5 Hz, 1H), 6.49 (t,./ 7. 1Hz, 1H), 6.74 – 6,83 (m, 1 I D. 6.87 (ddd, J=l 1.0, 8.4, 3.1Hz, 1H), 7.03 (td,,7=9.2, 5.5 Hz, 1H), 7.64 (dd, J=6.6, 1.8 Hz, 1H), 8.43 (d, J=2.2 Hz, 1H), 8.60 (dd, J=7.3, 2.0 Hz, 1H), 9.07 (d, J=2.2 Hz, 1H), 12.23 (s, 1H); ESI-MS m/z] M · Pi | 590.0.

The synthetic route of 15506-18-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; GREEN, Jason; HOPKINS, Maria; JONES, Benjamin; KIRYANOV, Andre A.; KUEHLER, Jon; MONENSCHEIN, Holger; MURPHY, Sean; NIXEY, Thomas; SUN, Huikai; (300 pag.)WO2018/183145; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem