Application of 156094-64-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.156094-64-3, name is 3-Bromo-2-(bromomethyl)-6-methoxypyridine, molecular formula is C7H7Br2NO, molecular weight is 280.9446, as common compound, the synthetic route is as follows.
A mixture of 3-bromo-2-(bromomethyl)-6-methoxypyridine (1.4 g, 5.0 mmol), methyl 3-iodo-4-hydroxybenzoate (1.52 g, 5.5 mmol), potassium phosphate (1.6 mg, 7.5 mmol) in DMF (10 mL) was stirred at 60 C for 3 h. Then the reaction mixture was cooled to rt, diluted with water (40 mL), extracted with EA (80 mLx2). The combined organic layers were washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography eluted with PE/EA (v/v = 20/1) to give the title compound as a white solid (2.2 g, 92 %).MS (ESI, pos. ion) m/z: 477.9 [M+H]t
The chemical industry reduces the impact on the environment during synthesis 156094-64-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; WANG, Xiaojun; YANG, Xinye; WU, Junwen; XIONG, Shaohui; PAN, Shengqiang; CAO, Shengtian; ZHANG, Yingjun; (121 pag.)WO2018/24224; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem