Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists was written by Simeone, Joseph P.;Bugianesi, Robert L.;Ponpipom, Mitree M.;Yang, Yi Tien;Lo, Jane-Ling;Yudkovitz, Joel B.;Cui, Jisong;Mount, George R.;Ren, Rena Ning;Creighton, Mellissa;Mao, An-Hua;Vincent, Stella H.;Cheng, Kang;Goulet, Mark T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Computed Properties of C7H8BrN This article mentions the following:
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-ethylpyridine (cas: 156761-88-5Computed Properties of C7H8BrN).
4-Bromo-2-ethylpyridine (cas: 156761-88-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C7H8BrN