Category: 1570-45-2

Reference of 1570-45-2 ,Some common heterocyclic compound, 1570-45-2, molecular formula is C8H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred solution of 5 (0.22 mL, 2.0 mmol) in THF (10 mL) was added LiAlH4 (113 mg, 3.0 mmol) at 0 C, and the resulting mixture was refluxed for 7 h. After cooling, the reaction was quenched with 10% NaOH (aq), and the aqueous mixture was extracted with EtOAc (10 mL 3). The extracts were combined, dried over K2CO3, and evaporated to give alcohol, which was used directly in the next step. To a stirred solution of the alcohol obtained above in DMF (5 mL) was added NaH (60%, 88 mg, 2.2 mmol) at 0 C, and the reaction mixture was stirred at room temperature for 0.5 h. To the reaction mixture was added benzyl chloride (0.23 mL, 2.0 mmol) at 0 C, and the reaction mixture was stirred at room temperature for 2 h. The reactionwas quenched with H2O, and the aqueous mixture was extracted with EtOAc (10 mL x 3). The extracts were combined, dried over K2CO3, and evaporated to give residue, which was chromatographed on silica gel (15 g, hexane:acetone = 10:1) to give 6a (250 mg, 63%) as a pale yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1570-45-2, its application will become more common.

Reference:
Article; Ichihara, Yoshinori; Fujimura, Ryohei; Tsuneki, Hiroshi; Wada, Tsutomu; Okamoto, Kentaro; Gouda, Hiroaki; Hirono, Shuichi; Sugimoto, Kenji; Matsuya, Yuji; Sasaoka, Toshiyasu; Toyooka, Naoki; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 649 – 660;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1570-45-2, name is Ethyl isonicotinate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.COA of Formula: C8H9NO2

In an autoclave, the reactant and Ru(acac)3 were dissolved with 1.4 equivalents of tris(diphenylphosphinomethyl)ethane in isopropanol, and converted at 150 C. and 150 bar of hydrogen pressure for 24 h. After the reaction, the reaction mixture was analyzed by gas chromatography.Conversion, selectivity and yield were determined by means of gas chromatography. Substrates, batch sizes and analysis are compiled in Table 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1570-45-2, Ethyl isonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; US2009/43102; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem