Category: 1570-48-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1570-48-5, name is 1-(Pyridin-3-yl)propan-1-one. A new synthetic method of this compound is introduced below., Safety of 1-(Pyridin-3-yl)propan-1-one

A solution of the 3-propionylpyridine (5g, 37 mmol) , (S)-(-)-2-methylpropane-2- sulfinamide (4.7 g, 38.8 mmol) and titanium (IV) ethoxide (17.8g, 78 mmol) in THF (100 mL) was heated at 80C for 3 days. After cooling, brine (100 mL) and EA (100 mL) were added. The mixture was stirred at RT for 1 h. The mxture was filtered through Celite, and the pad was washed with EA. The organic phase was seperated, concentrated, and the residue was chromatographed (eluted with 2:1 hexane:EA) to give the product as a colorless oil (8.15g, 92%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1570-48-5, 1-(Pyridin-3-yl)propan-1-one.

Reference:
Patent; EXITHERA PHARMACEUTICALS, INC.; CHENARD, Bertrand, L.; XU, Yuelian; STASSEN, Frans, L.; HAYWARD, Neil, J.; (225 pag.)WO2018/118705; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1570-48-5, 1-(Pyridin-3-yl)propan-1-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9NO, blongs to pyridine-derivatives compound. Computed Properties of C8H9NO

Precursor 3 n: 1-Pyridin-3-yl-propylamine 0.9 g of the title compound was obtained from 1 g of 3-propionylpyridine according to general method 3 B. Precursor 3 s: 1-Cyclopropyl-1-phenylmethylamine Hydrochloride

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1570-48-5, 1-(Pyridin-3-yl)propan-1-one, and friends who are interested can also refer to it.

Reference:
Patent; Brendel, Joachim; Pirard, Bernard; Peukert, Stefan; Kleemann, Heinz-Werner; Hemmerle, Horst; US2003/187033; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1570-48-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1570-48-5, name is 1-(Pyridin-3-yl)propan-1-one, molecular formula is C8H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of 2-methylcyclopropanecarboxylic acid [1-(3-pyridinyl)propylidene]hydrazide, Compound 313 A mixture of 8.0 gm (0.07 mole) of 2-methylcyclopropanecarboxylic acid hydrazide, 9.46 gm (0.07 mole) of ethyl-3-pyridyl ketone, 10 drops of glacial acetic acid and 100 ml of EtOH was refluxed 20 hr. Tlc (9:1 Skellysolve B/Ethyl acetate on silica gel) shows no remaining starting material. The reaction mixture was cooled to room temperature and evaporated in vacuo to give a liquid. The liquid solidified on standing. The solid was slurried in ether, collected and dried to give 4.77 gm (29%) of the title compound having a melting point of 137.3 C. Analysis Calcd: C, 67.51; H, 7.41; N, 18.86. Found: C, 66.99; H, 7.48; N, 18.08.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1570-48-5, 1-(Pyridin-3-yl)propan-1-one.

Reference:
Patent; Upjohn Company; US5011932; (1991); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem