Category: 15854-87-2

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15854-87-2, name is 4-Iodopyridine, molecular formula is C5H4IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4-Iodopyridine

General procedure: A mixture of aryl halide (1.0 mmol), K4[Fe(CN)6](0.22 mmol), 0.05 g [PS-ttet-Pd(II)], and sodium carbonate(1.0 mmol) was stirred in 5 cm3 DMF at 120 C for 1 h under an argon atmosphere. To the aryl nitrile compound generated in situ was added sodium azide (1.5 mmol) and the mixture was stirred at 120 C for appropriate time. After completion of the reaction (as indicated by TLC), the catalyst was centrifuged, washed with EtOH and the residue was diluted with 35 cm3 ethyl acetate and 20 cm3 HCl(4 N) and stirred vigorously. The resultant organic layer was separated and the aqueous layer was extracted with 25 cm3 ethyl acetate. The combined organic layer was washed with 8 cm3 water and concentrated to give a crude product. Column chromatography using silica gel gave thepure product. All products were characterized by 1H NMR and melting point which were in agreement with literature

With the rapid development of chemical substances, we look forward to future research findings about 15854-87-2.

Reference:
Article; Tajbakhsh, Mahmood; Alinezhad, Heshmatollah; Nasrollahzadeh, Mahmoud; Kamali, Taghi A.; Monatshefte fur Chemie; vol. 147; 12; (2016); p. 2135 – 2142;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 15854-87-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15854-87-2, name is 4-Iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.

The intermediates and final products were obtained via establishedcross-coupling reactions [5,15,17]. Briefly, 4-trimethylsililyethynylpyridine was obtained by reacting an equimolarquantity of 4-iodopyridine (2.0 mmol) with trimethylsilylethyne(TMSE, 2.0 mmol) in THF/iPrNH2 using Pd(II)/Cu(I) catalysts(Scheme 1). The crude product obtained was purified by silicacolumn chromatography using hexane/dichloromethane eluantsystems. This was followed by a protodesilylation reaction underbasic condition (aq. KOH in MeOH/THF) and the 4-ethynylpyridinewas separated by silica column chromatography using puredichloromethane as eluant. In the next phase of the reaction,respective aryl halides (2.0 mmol) and 4-ethynylpyridine (2.0mmol) were coupled via a Sonogashira cross-coupling reaction.Final products were purified using an alumina column and obtainedas tan to light brown solid in quantitative yields.

According to the analysis of related databases, 15854-87-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Haque, Ashanul; Al Balushi, Rayya A.; Al-Busaidi, Idris Juma; Ilmi, Rashid; Al Rasbi, Nawal; Jayapal, Maharaja; Khan, Muhammad S.; Raithby, Paul R.; Journal of Organometallic Chemistry; vol. 892; (2019); p. 75 – 82;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem