Category: 15862-31-4

Introduction of a new synthetic route about 15862-31-4

Statistics shows that 15862-31-4 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-nitropyridin-2-amine.

Synthetic Route of 15862-31-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15862-31-4, name is 3-Bromo-5-nitropyridin-2-amine, molecular formula is C5H4BrN3O2, molecular weight is 218.01, as common compound, the synthetic route is as follows.

Compound 1 (2.6 g, 12.52 mmol) and iodo benzene (2.5 g,13.77 mmol )were dissolved in Toluene( 25 m) and the solution was degassed with argon. Palladium acetate (0.28 g, 6.26 mmol ) ,xanthaphos (0.545 g, 1.252 mmol) , sodium tertiary butaoxide(l .65 g, 18.78 mmol )were added. The reaction was heated at reflux under argon for 2h.The solvent was removed in vacuum and crude mass was purified by column chromatography by eluting with 20percent ethyl acetate in pet ether to get desired compound 2 ( 1 g )

Statistics shows that 15862-31-4 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-nitropyridin-2-amine.

Reference:
Patent; VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita; WO2013/42035; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 3-Bromo-5-nitropyridin-2-amine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-31-4, its application will become more common.

Related Products of 15862-31-4 ,Some common heterocyclic compound, 15862-31-4, molecular formula is C5H4BrN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Into a 30-mL flask, compound 2a-c was suspended in MeOH(6.0 mL). A solution of NH4Cl (5.0 equivalent.) in H2O (6.0 mL)was added followed by Fe powder (5.0 equivalents.). The suspensionwas stirred at 80 C for 2 h. which was filtered off at about50 C. The filtrate was concentrated and purified by column chromatography(KANTO 60 N, CH2Cl2/MeOH = 97/3 to 92/8) to give ared solid compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-31-4, its application will become more common.

Reference:
Article; Wang, Lei; Taniguchi, Yosuke; Okamura, Hidenori; Sasaki, Shigeki; Bioorganic and Medicinal Chemistry; vol. 25; 14; (2017); p. 3853 – 3860;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem