A new synthetic route of 15862-37-0

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15862-37-0, 2,5-Dibromo-3-nitropyridine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15862-37-0, name is 2,5-Dibromo-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2Br2N2O2

5-Bromo-2-(3-methoxyphenyl)-3-nitropyridine A stirred mixture of 2,5-dibromo-3-nitropyridine (0.2621 g, 0.930 mmol), 3-methoxyphenylboronic acid (0.155 g, 1.02 mmol), tetrakis(triphenylphosphine)-palladium (0.076 g, 0.065 mmol), and 2.0M sodium carbonate (2.4 mL, 4.80 mmol) in toluene (3.0 mL) and ethanol (1.0 mL) was heated to 70 C. After 2.5 h, the reaction was cooled to rt then diluted with water. After extraction with EtOAc, the organic extraction was dried over anhydrous sodium sulfate. After filtration and concentration, the residue was purified on silica gel (0-20% EtOAc in hexanes) to afford a yellow solid as 5-bromo-2-(3-methoxyphenyl)-3-nitropyridine. 1H NMR (400 MHz, CDCl3) delta ppm 8.91 (1H, d, J=2.2 Hz), 8.27 (1H, d, J=2.2 Hz), 7.42 (1H, m), 7.14 (3H, m), 3.86 (3H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15862-37-0, 2,5-Dibromo-3-nitropyridine.

Reference:
Patent; AMGEN INC.; US2010/331293; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 2,5-Dibromo-3-nitropyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-37-0, its application will become more common.

Reference of 15862-37-0 ,Some common heterocyclic compound, 15862-37-0, molecular formula is C5H2Br2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: Methyl 4-(5-bromo-3-nitropyridin-2-yl)-3-fluorobenzoateTo a solution of (2-fluoro-4-(methoxycarbonyl)phenyl)boronic acid (0.5 00 g, 2.53mmol) and 2,5-dibromo-3-nitropyridine (0.7 12 g, 2.53 mmol) in THF (8.42 mL) wasadded aq. tripotassium phosphate (2M, 2.53 ml, 5.05 mmol). The reaction was degassedwith bubbling nitrogen, then PdC12(dppf)-CH2C12 adduct (0.124 g, 0.152 mmol) wasadded and the reaction was heated to 70 C for 2 h. The reaction was cooled, diluted withwater, and extracted 3 times with EtOAc. The combined organics were concentrated.The residue was purified via ISCO silica gel chromatography (40 g column; Hex/EtOAc;0 to 100%) to give methyl 4-(5-bromo-3-nitropyridin-2-yl)-3-fluorobenzoate (0.6 10 g,68%). ?H NMR (400MHz, CDC13) oe 9.01 (d, J2.1 Hz, 1H), 8.54 (d, J=2.1 Hz, 1H), 8.02(dd, J8.0, 1.5 Hz, 1H), 7.84-7.73 (m, 2H), 3.97 (s, 3H); LCMS (M+H) = 355.1; HPLC RT = 1.15 mm. Analytical HPLC Method 1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-37-0, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; NORRIS, Derek J.; DELUCCA, George V.; GAVAI, Ashvinikumar V.; QUESNELLE, Claude A.; GILL, Patrice; O’MALLEY, Daniel; VACCARO, Wayne; LEE, Francis Y.; DEBENEDETTO, Mikkel V.; DEGNAN, Andrew P.; FANG, Haiquan; HILL, Matthew D.; HUANG, Hong; SCHMITZ, William D.; STARRETT, JR, John E.; HAN, Wen-Ching; TOKARSKI, John S.; MANDAL, Sunil Kumar; WO2015/100282; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: Electric Literature of 15862-37-0

According to the analysis of related databases, 15862-37-0, the application of this compound in the production field has become more and more popular.

Electric Literature of 15862-37-0, Adding some certain compound to certain chemical reactions, such as: 15862-37-0, name is 2,5-Dibromo-3-nitropyridine,molecular formula is C5H2Br2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15862-37-0.

To a solution of 2,5-dibromo-3-nitropyridine (5.00 g, 17.8 mmol) in EtOH (20 mL), water (27 mL) and toluene (30 mL) was added thiophen-3 -ylboronic acid (2.39 g, 18.7 mol) and Na2CO3 (5.68 g, 53.6 mol) under N2. The mixture was purged with N2 for 2 mm and followed by addition of tetrakis(triphenylphosphine)palladium (1.04 g, 0.900 mmol). The reaction mixture was heated to reflux for 16 h. Then the reaction mixture was cooled to r.t.and extracted with EtOAc (100 mL). The collected organic phase was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography using 0-5% EtOAc in hexane to afford the title compound (3.84 g, 76% yield) as a light yellow solid. LC-MS [M+H]= 286.

According to the analysis of related databases, 15862-37-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JACOBIO-BETA PHARMACEUTICALS CO., LTD.; JACOBIO-ALPHA PHARMACEUTICALS CO., LTD.; JACOBIO PHARMACEUTICALS CO., LTD.; FANG, Haiquan; ZHOU, Wenlai; HU, Shaojing; CHEN, Mingming; YANG, Guiqun; WANG, Yanping; DU, Yuelei; LI, Qinglong; WU, Tong; WU, Lingjun; LI, Haijun; LONG, Wei; (179 pag.)WO2019/80941; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem