Category: 15862-50-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15862-50-7, name is 3-Bromo-2-methoxy-5-nitropyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 3-Bromo-2-methoxy-5-nitropyridine

Step 1: tert-Butyl (1-(4-((2-methoxy-5-nitropyridin-3-yl)ethynyl)phenyl)cyclobutyl) carbamate: 3-Bromo-2-methoxy-5-nitropyridine (161 mg, 0.691 mmol) was stirred in 1 : 1 , Et3N/1 ,4-dioxane (1.5 mL) at RT and the reaction mixture degassed under an atmosphere of N2. The temperature was reduced to 0 C and Pd(‘Bu3P)2 (14.1 mg, 0.0276 mmol) was added. After 10 minutes, Cu(l)l (1.3 mg, 0.0092 mmol), followed by dropwise addition of tert-butyl (1-(4-ethynylphenyl)cyclobutyl)carbamate (125 mg, 0.461 mmol) in Et3N (0.75 mL). After 4 hours, the solvents were removed in vacuo, coevaporating to remove residual Et3N. The residue was dissolved in DCM, filtered through Celite, washing with DCM. The solvents were removed in vacuo and the remaining residue was purified by flash chromatography (Si02, 0?25%, EtOAc in n- hexane) to give the title compound (127 mg, 65%) as a pale yellow solid. 1H NMR (500 MHz, CDCI3): delta 9.00 (d, 1 H), 8.50 (d, 1 H), 7.55 (d, 2H), 7.44 (d, 2H), 5.13 (s, 1 H), 4.15 (s, 3H), 2.62-2.43 (m, 4H), 2.18-2.08 (m, 1 H), 1.94-1.83 (m, 1 H). 1.49-1.05 (m, 9H).

The synthetic route of 15862-50-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALMAC DISCOVERY LIMITED; BELL, Mark, Peter; O’DOWD, Colin, Roderick; ROUNTREE, James, Samuel, Shane; TREVITT, Graham, Peter; HARRISON, Timothy; MCFARLAND, Mary, Melissa; WO2011/55115; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-Bromo-2-methoxy-5-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 3-Bromo-2-methoxy-5-nitropyridine

A slurry of potassium carbonate (4.45 g, 32.2 mmol), potassium isopropenyltrifluoroborate (9b; 3.18 g, 21.46 mmol), PdCl2(AmPhos)2(0.152 g, 0.215 mmol), and 3-bromo-2-methoxy-5-nitropyridine (30b, 2.50 g, 10.73 mmol) in dioxane (50 mL) and water (20 mL) was sparged with nitrogen for 5 min, then placed in a sealed vessel and heated at 80 C for 1 h. The reaction mixture was then cooled to ambient temperature and partitioned between water and DCM. The organic layer was separated, and the aqueous layer was extracted with DCM (3×). The combined organic extracts were then dried over sodium sulfate, filtered, and concentrated in vacuo to give 2-methoxy-5-nitro-3-(prop-1-en-2-yl)pyridine (2.27 g, 11.69 mmol, >99% yield) as a red solid, which was used without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Article; Lanman, Brian A.; Reed, Anthony B.; Cee, Victor J.; Hong, Fang-Tsao; Pettus, Liping H.; Wurz, Ryan P.; Andrews, Kristin L.; Jiang, Jian; McCarter, John D.; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Wang, Ling; Whittington, Douglas A.; Wu, Tian; Zalameda, Leeanne; Zhang, Nancy; Tasker, Andrew S.; Hughes, Paul E.; Norman, Mark H.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5630 – 5634;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15862-50-7, name is 3-Bromo-2-methoxy-5-nitropyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H5BrN2O3

The title compound (Intermediate 65, 6.20 g, 32.9 mmol) was prepared in four steps from 3-bromo-2-methoxy-5-nitropyridine (Intermediate 64, 20.0 g total, 85.8 mmol),tributyl(1-ethoxyvinyl)stannane (31.1 g total, 86.1 mmol) andtetrakis(triphenylphosphine)palladium(0) (5.97 g total, 5.17 mmol) in DMAC (200 mL total) in a microwave reactor at 135C for 15 mm (reactions were carried out in 10 equal scale batches under identical conditions); aqueous HC1 (1M, 93.0 mL) in THF (95 mL) at rt for 2 h; DAST (27 mL) at 50C for 16 h; and iron powder (10.3 g, 184 mmol) and ammonium chloride (17.7 g, 331 mmol) in EtOH/water (5:2, 140 mL) at 80C for 4 h, using the methods of Intermediate 56.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine.

Reference:
Patent; HEPTARES THERAPEUTICS LIMITED; CHRISTOPHER, John Andrew; BUCKNELL, Sarah Joanne; CONGREVE, Miles Stuart; TEHAN, Benjamin Gerald; NONOO, Rebecca Helen; BROWN, Giles Albert; SWAIN, Nigel Alan; MILLS, Mark; (111 pag.)WO2019/86902; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem