Related Products of 1589541-56-9 ,Some common heterocyclic compound, 1589541-56-9, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of compound 6-amino-2,4-dichloronicotinonitrile (0.26 g, 1.37mmol) in chloroform (7.0 mL) was added diisopropylethylamine (0.49 mL, 2.75 mmol)followed by imidazole (0.47 g, 6.87 mmol) and CDI (1.15 g, 6.87 mmol) at 0 C and allowed to stir at room temperature for 12 h. After the clear solution is formed (R)-(+)-phenyl ethyl amine (1.08 g, 8.9 mmol) was added at room temperature and stirred for 2 h. After confirming the completion of starting material by TLC, the reaction mixture was concentrated underreduced pressure and dissolved in ethyl acetate and then washed with water. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure to get crude product which was purified by column chromatography (hexanes:ethyl acetate=7:3) to afford desired product. 1H NMR (ppm, 400 MHz, DMSO-d6): delta 10.07 (s, 1H), 8.03 (s, 1H), 7.37-7.32 (m, 5H), 7.28-7.24 (m, 1H), 4.84 (t, J= 8.00 Hz, 1H), 1.41 (d, J= 8.00Hz, 3H). MS ES calc?d. for C15H12Cl2N4O [M+H]+ 335; Found 335.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1589541-56-9, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WILSON, Kevin, J.; WITTER, David, J.; SILIPHAIVANH, Phieng; LIPFORD, Kathryn; SLOMAN, David; FALCONE, Danielle; O’BOYLE, Brendan; MANSOOR, Umar Faruk; LIM, Jongwon; METHOT, Joey, L.; BOYCE, Christopher; CHEN, Lei; DANIELS, Matthew, H.; FEVRIER, Salem; HUANG, Xianhai; KURUKULASURIYA, Ravi; TONG, Ling; ZHOU, Wei; KOZLOWSKI, Joseph; MALETIC, Milana, M.; SHINKRE, Bidhan, A.; THATAI, Jayanth Thiruvellore; BAKSHI, Raman Kumar; KARUNAKARAN, Ganesh Babu; WO2014/52563; (2014); A2;,
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