Category: 159307-02-5

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 159307-02-5, name is 6-Acetylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H6N2O

Step c. To a solution of 6-acetylpicolinonitrile (0.1 g, 0.68 mmol) in acetic acid (10 ml) was added bromine (0.108 g, 0.68 mmol) in glacial acetic acid (5 ml) drop wise at 15C. The reaction mixture was stirred at rt for 20 h. The resulting reaction mixture was poured into saturated NaHC03 solution (30 ml) and neutralized with slow addition of solid Na2C03. The obtained mixture was extracted with EtOAc (3 x 40 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure yielding 6-(2-bromoacetyl)picolinonitrile (0.4 g, 1.77 mmol). MS: ES+ 224.7; 226.7.

With the rapid development of chemical substances, we look forward to future research findings about 159307-02-5.

Reference:
Patent; MISSION THERAPEUTICS LIMITED; KEMP, Mark; STOCKLEY, Martin; JONES, Alison; (138 pag.)WO2017/9650; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.159307-02-5, name is 6-Acetylpicolinonitrile, molecular formula is C8H6N2O, molecular weight is 146.15, as common compound, the synthetic route is as follows.Application In Synthesis of 6-Acetylpicolinonitrile

Compound 4b:to 100 ml by adding three-necked bottle of 2-cyano-6-acetyl-pyridine (3.00g, 20 . 53mmol), 2,6-dimethyl aniline (2.74g, 22 . 58mmol), the toluene sulphonic acid monohydrate (195 mg, 1 . 03mmol), solvent toluene and 50 ml, reflux device installed, heating reaction refluxing 48h. Cooling to room temperature, vacuum concentration, rapid column chromatography purification (ethyl acetate: petroleum ether = 1:20), to get the yellow oily matter (5.04g, 96%),

At the same time, in my other blogs, there are other synthetic methods of this type of compound,159307-02-5, 6-Acetylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Institute of Organic Chemistry; Huang, Zheng; Zuo, Ziqing; Zhang, Lei; (50 pag.)CN105294667; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 159307-02-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.159307-02-5, name is 6-Acetylpicolinonitrile, molecular formula is C8H6N2O, molecular weight is 146.15, as common compound, the synthetic route is as follows.

Compound 4a:to 100 ml by adding three-necked bottle of 2-cyano-6-acetyl-pyridine (2.00g, 13 . 68mmol), 2,6-diisopropyl aniline (2.91g, 16 . 42mmol), the toluene sulphonic acid monohydrate (130 mg, 0 . 68mmol), solvent toluene and 35 ml, reflux device installed, heating reaction refluxing 48h. Cooling to room temperature, vacuum concentration, rapid column chromatography purification (ethyl acetate: petroleum ether = 1:30), to get the yellow solid (4.05g, 97%),

Statistics shows that 159307-02-5 is playing an increasingly important role. we look forward to future research findings about 6-Acetylpicolinonitrile.

Reference:
Patent; Shanghai Institute of Organic Chemistry; Huang, Zheng; Zuo, Ziqing; Zhang, Lei; (50 pag.)CN105294667; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem