Category: 1594-57-6

Application of 1594-57-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1594-57-6, name is N-Hydroxyisonicotinimidamide, molecular formula is C6H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Zn(CH3COO)2·2H2O (21.9 mg, 0.1 mmol) and pyridine-4-amidoxime (27.4 mg, 0.2 mmol) were dissolved in a 30 mL mixture of methanol and dimethylformamide (2:1). The reaction mixture was boiled and stirred for ?20 min, filtered off and then slowly cooled to room temperature, giving yellow crystals. Yield: ?23%. Anal. Calc. for C16H20N6O6Zn: C, 41.98; H, 4.40; N, 18.35. Found: C, 41.25; H, 4.33; N, 18.09%. UV-Vis (CH3OH) [lambdamax, nm (epsilon, dm3 M-1 cm-1)]: 210 (27 619), 273 (9115). IR (cm-1): 3456 (w), 1648 (m), 1614 (v.s), 1586 (v.s), 1550 (s), 1424 (s), 1380 (v.s), 1333 (s), 1223 (m), 1073 (m), 1028 (m), 955 (m), 939 (m), 839 (s), 676 (m), 453 (w), 411 (w).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1594-57-6, N-Hydroxyisonicotinimidamide.

Reference:
Article; Coropceanu, Eduard B.; Croitor, Lilia; Siminel, Anatolii V.; Fonari, Marina S.; Polyhedron; vol. 75; (2014); p. 73 – 80;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1594-57-6 ,Some common heterocyclic compound, 1594-57-6, molecular formula is C6H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: a) To a mixture of the carboxylic acid (5 mmol) in acetone (20 mL) was added EDC (5.5 mmol). The reaction mixture was stirred at room temperature for 30 min, then the amidoxime (5 mmol) was added. The resulting mixture was stirred at room temperature for 12 h. Acetone was evaporated at reduced pressure and to the residue was added water (100 mL). The resulting precipitate was filtered off, washed with water (50 ml) and dried under vacuum at rt.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1594-57-6, its application will become more common.

Reference:
Article; Baykov, Sergey; Sharonova, Tatyana; Osipyan, Angelina; Rozhkov, Sergey; Shetnev, Anton; Smirnov, Alexey; Tetrahedron Letters; vol. 57; 26; (2016); p. 2898 – 2900;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1594-57-6, name is N-Hydroxyisonicotinimidamide, molecular formula is C6H7N3O, molecular weight is 137.14, as common compound, the synthetic route is as follows.category: pyridine-derivatives

Example 1: 4- (3-Pyridin-4-yl- [1, 2,4] oxadiazol-5-ylmethoxy) piperidine-1-carboxylic acid tert- butyl ester A stirred solution of triethylamine (123mul, 0. 87mmol) and 4-carboxymethoxypiperidine- 1-carboxylic acid tert-butyl ester (Preparation 1,227mg, 0. 87mmo1) in toluene (10ml) was treated with isobutylchloroformate (113mul, 0. 87mmol). After 20min, activated powdered 3A molecular sieves (0.7g) andN-hydroxyisonicotinamidine (lOOmg, 0. 73mmol) were added and the mixture heated under reflux for 18h. On cooling, the mixture was filtered through celite, the solvent removed in vacuo and the residue purified by flash chromatography (IH-EtOAc, 7: 13) to afford the title compound: RT = 3. 29min ; m/z (ES+) 361.3 [M+H] + ; OH (CDC13) 1.40 (9H, s), 1.55-1. 63 (2H, m), 1.80-1. 92 (2H, m), 3.05-3. 15 (2H, m), 3.64-3. 79 (3H, m), 4.80 (2H, s), 7.90 (2H, d), 8.75 (2H, d).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1594-57-6, N-Hydroxyisonicotinimidamide, and friends who are interested can also refer to it.

Reference:
Patent; PROSIDION LIMITED; WO2005/61489; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1594-57-6 ,Some common heterocyclic compound, 1594-57-6, molecular formula is C6H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 4- (Boc-aminomethyl)-benzoic acid (187 mg) in DMF (0.25 M) were added DIEA (5 eq), TBTU (1 eq) and HOBt (0.2 eq). The solution was stirred at RT for 3 minutes, and then isonicotinamide oxime (102mg, 1 eq) was added. After 1 hour, the solvent was evaporated. The residue was triturated with 0.05 M NaOH (5 ml). The solid was filtered off, washed with water and dried under vacuum. The solid was dissolved in DMF (0.25 M). The reaction mixture was heated at 110C for 2 hours. The reaction mixture was cooled down at RT. The precipitate was filtered off, washed with water, and then dried under vacuum. The solid was dissolved in 3N HCI. The solution was heated at 50C for 2 hours. The solvent was evaporated and the residue was dried under vacuum. The title product was obtained as a white powder (74% yield).’H NMR (300 MHz, DMSO-d6): 4.15 ppm (q, 2H, J=5.7 Hz); 5.00 ppm (bs, 2H); 7.80 ppm (d, 2H, J=8.4 Hz); 8.24 ppm (m, 4H); 8.95 ppm (d, 2H, J=6.0 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1594-57-6, N-Hydroxyisonicotinimidamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DEVGEN NV; WO2005/82367; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1594-57-6, name is N-Hydroxyisonicotinimidamide, molecular formula is C6H7N3O, molecular weight is 137.14, as common compound, the synthetic route is as follows.COA of Formula: C6H7N3O

Preparation 3: trans-4- (3-Pyridin-4-yl- [1, 2,4] oxadiazol-5-yl) cyclohexanecarboxylic acid methyl ester A solution of cyclohexane-1, 4-dicarboxylic acid monomethyl ester (1.053g, 5.66mmol) and triethylamine (800gel, 5. 66mmol) in toluene (30ml) was cooled to 0C and isobutylchloroformate (735} il, 5. 66mmol) introduced dropwise. The mixture was stirred at rt for 30min whereupon activated, powdered 3A molecular sieves (5g) and N- hydroxyisonicotinamidine (705mg, 5.14mmol) were added. The mixture was heated under reflux for 18h, cooled and filtered through celite. The solvent was removed in vacuo and the residue purified by flash chromatography (IH-EtOAc, 1: 1) to afford the title compound: RT = 3. 20min ; m/z (ES) = 288. 2 [M+H] +.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1594-57-6, N-Hydroxyisonicotinimidamide, and friends who are interested can also refer to it.

Reference:
Patent; PROSIDION LIMITED; WO2005/61489; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1594-57-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1594-57-6, name is N-Hydroxyisonicotinimidamide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 0.51 g 3-fluoro-4-methoxybenzoic acid (2,3 mmol) in 10 cm3 of DMF 1.15 g 1-[bis(dimethylamino)methylene]-1H-[1,2,3]-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate (HATU, 3 mmol) was addedfollowed by 1 cm3 N-methylmorpholine (9 mmol) andlastly substituted aryl amidoximes 1a-1f in DMF. Thereaction mixture was stirred and refluxed for 3 h. Afterremoval of solvent under vacuum, the reaction mixture waspurified on a silica gel column eluting with 1-5 %methanol in dichloromethane. The desired 3,5-disubstituted1,2,4-oxadiazoles were isolated and crystallized from ethanol.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1594-57-6, N-Hydroxyisonicotinimidamide.

Reference:
Article; Dinesha; Viveka, Shivapura; Khandige, Prasanna S.; Nagaraja, Gundibasappa K.; Monatshefte fur Chemie; vol. 147; 2; (2016); p. 435 – 443;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem