Category: 1594-58-7

Application of 1594-58-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1594-58-7, name is N-Hydroxynicotinimidamide, molecular formula is C6H7N3O, molecular weight is 137.14, as common compound, the synthetic route is as follows.

3-(3-(pyridin-3-yl)-1 ,2,4-oxadiazol-5-yl)benzonithle 3-Pyridylamideoxime (Aldrich, 5.5 g, 40 mmol) was dissolved in 60 mL of pyridine and 3-cyanobenzoyl chloride (Aldrich, 6.6 g, 40 mmol) was added. The reaction mixture was heated to reflux for 4 hours and then cooled to room temperature. The solution was poured into water (500 mL), filtered, and the solid were collected and dried under vacuum. ^ H NMR (300 MHz, methanol- d4) delta ppm 7.87 (td, J=8.0, 0.7 Hz, 1 H), 8.10 (dt, J=8.1 , 1.4 Hz, 1 H), 8.23 (ddd, J=8.1 , 5.6, 0.8 Hz, 1 H), 8.56 (ddd, J=8.0, 1.7, 1.2 Hz, 1 H), 8.64 (td, J=1 .7, 0.7 Hz, 1 H), 9.04 (dd, J=5.4, 1 .0 Hz, 1 H), 9.23 (dt, J=8.1 , 1 .7 Hz, 1 H), 9.57 (d, J=1.7 Hz, 1 H); MS (+ESI) m/z 249 (M+H)+.

Statistics shows that 1594-58-7 is playing an increasingly important role. we look forward to future research findings about N-Hydroxynicotinimidamide.

Reference:
Patent; ABBOTT LABORATORIES; WO2008/73942; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1594-58-7, name is N-Hydroxynicotinimidamide, molecular formula is C6H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of N-Hydroxynicotinimidamide

Add 0.05 mol (6.85 g) to a 250 mL three-necked flaskN-hydroxynicotinamide,100mL acetonitrile as solvent,0.055 mol (5.5 g) of triethylamine as an acid binding agent, and stirring, 0.05 mol (16.5 g) of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride Diluted with 50 mL of ethyl acetate and added dropwise to the reaction flask.The reaction was carried out for 2 h after the completion of the dropwise addition.TLC monitoring until the reaction is complete,Add an appropriate amount of saturated sodium bicarbonate solution,Filtering,Made a brown solid,Rinse with methanol to obtain 18.1 g of a yellow solid.The yield was 96.02%.

With the rapid development of chemical substances, we look forward to future research findings about 1594-58-7.

Reference:
Patent; Qingdao University of Science and Technology; Wang Minghui; Xu Liangzhong; Liu Liancai; Sun Jianxin; Cui Huanqi; (7 pag.)CN109336879; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1594-58-7, name is N-Hydroxynicotinimidamide, the common compound, a new synthetic route is introduced below. Safety of N-Hydroxynicotinimidamide

To a solution of 5-(lH-pyrrol-l-yl)nicotinic acid (Maybridge, 188 mg, 1.00 mmol) in dimethylformamide (anhydrous, 5 mL) was added N-(3-methylaminopropyl)-N’- ethylcarbodiimide hydrochloride (EDC) (Aldrich, 192 mg, 1.00 mmol) and 1- hydroxybenzotriazole (HOBT) hydrate (Fluka, 153 mg, 1.00 mmol). The mixture was stirred at ambient temperature for 20 minutes. lambdaf’-Hydroxynicotinimidamide (137 mg, 1.0 mmol) was added and the mixture was stirred for 6-10 hours, and then warmed to 140 0C for 2-4 hours. The reaction was cooled to ambient temperature and triturated with water (10 mL). The precipitate was filtered and dried under vacuum to give the titled compound. 1H NMR (300 MHz, DMSO-J6) delta 6.34 – 6.44 (m, 2 H), 7.60 – 7.82 (m, 3 H), 8.50 (dt, J=8.1, 1.9 Hz, 1 H), 8.71 (dd, J=2.5, 1.9 Hz, 1 H), 8.84 (dd, J=4.6, 1.5 Hz, 1 H), 9.21 (d, J=1.7 Hz, 1 H), 9.26 (d, J=2.4 Hz, 1 H), 9.31 (d, J=I .7 Hz, 1 H) ppm; MS (DCI/NH3) m/z 290 (M+H)+.

The synthetic route of 1594-58-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; WO2009/148452; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1594-58-7, Adding some certain compound to certain chemical reactions, such as: 1594-58-7, name is N-Hydroxynicotinimidamide,molecular formula is C6H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1594-58-7.

General procedure: The newly synthesized acyl chloride dissolved intoluene (10 mL) was slowly added to a solution ofamidoxime (2.5 mmol) dissolved in toluene (40 mL) in a250 mL round-bottomed flask at 25 oC and under constantstirring. After the addition, the solution was refluxed for20 h, and then washed with sodium carbonate solution. Theorganic phase was dried with anhydrous sodium sulfateand thereafter the toluene was removed under vacuumby heating. A solid was obtained, which was purified byfash column chromatography using a hexane/ethyl acetatemixture as eluent with an increasing polarity gradient (9:1to 6:4).20

According to the analysis of related databases, 1594-58-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cunha, Felipe S.; Nogueira, Joseli M. R.; De Aguiar, Alcino P.; Journal of the Brazilian Chemical Society; vol. 29; 11; (2018); p. 2405 – 2416;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1594-58-7, Adding some certain compound to certain chemical reactions, such as: 1594-58-7, name is N-Hydroxynicotinimidamide,molecular formula is C6H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1594-58-7.

General procedure: Parent amidoxime (2mmol) was dissolved in the indicated solvent (0.15M) and cooled to 0C under an argon atmosphere. Triethylamine (0.28mL, 2mmol) was added, followed by the required sulfonyl chloride (2mmol) and the mixture was stirred for the indicated period allowing the temperature to slowly rise to 25C. Then, water (70mL) was added and the mixture was extracted with dichloromethane (2×70mL). The combined organic extracts were dried (Na2SO4) and concentrated under vacuum (rotary evaporator) to give a residue which was either recrystallized or purified using column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1594-58-7, N-Hydroxynicotinimidamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Doulou, Ismini; Kontogiorgis, Christos; Koumbis, Alexandros E.; Evgenidou, Eleni; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 145 – 153;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1594-58-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1594-58-7, name is N-Hydroxynicotinimidamide. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 15 4.7 g (5.5 ml; 55 mmol) of piperidine are added over 20 minutes to the solution of 5.1 g (4.3 ml; 55 mmol) of epichlorohydrin in 5.2 ml of tert-butanol under cooling by water while stirring vigorously. The reaction mixture is stirred at room temperature for 1 hour, then 50 ml of pure dry DMF, 6.9 g (50 mmol) of nicotinic acid amidoxime and 3.2 g (80 mmol) of powdered sodium hydroxide are added. After stirring the suspension at 70 C. for 12 hours the reaction mixture is worked up as described in Example 1 to give 13.2 g (75%) of O(3-amino-2-hydroxypropyl) nicotinic acid amidoxime dihydrochloride.

According to the analysis of related databases, 1594-58-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinoin Gyogyszar es Vegyeszeti Termekek Gyara Rt.; US5239077; (1993); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1594-58-7 ,Some common heterocyclic compound, 1594-58-7, molecular formula is C6H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-(Chloromethyl)-3-(pyridine-2-yl)-1 ,2,4-oxadiazole (SO2-065): To a solution of N- hydroxypicolinimidamide (0.2g g, 1 .5 mmol) in DCM (20 ml) and chloroacetyl chloride (0.2 g, 1 .8 mmol) at 0 C, diisopropylethylamine (0.23 g, 1 .8 mmol) was added (dropwise). The mixture was warmed up to r.t. and stirred for 24 h. and organic solvent was evaporated and the residue was refluxed overnight in toluene (20 ml_) to complete the cyclization. The product obtained was purified using Si02 chromatography (EtOAc: hexane gradient elution). The required compound SO2-065 (0.24 g, 81 %) was obtained as a white solid.1 H NM R (400 M Hz, CDCI3) delta 8.81 (ddd, J = 4.8, 1 .6, 1 .0 Hz, 1 H), 8.14 (d, J = 7.9 Hz, 1 H), 7.87 (ddd, J = 7.9 Hz, 4.8 , 1 .8 Hz, 1 H), 7.46 (ddd, J = 7.7, 4.8, 1 .2 Hz, 1 H), 4.79 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1594-58-7, its application will become more common.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; LAWRENCE, Harshani R.; SEBTI, Said M.; OZCAN, Sevil; WO2012/129564; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1594-58-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1594-58-7, name is N-Hydroxynicotinimidamide. A new synthetic method of this compound is introduced below.

General procedure: 0.002 mol amidoximes and 0.008 mol triethylamine dissolved in 10 ml dichloromethane. The solution was then instilled to 10 ml dichloromethane containing 0.004 mol Vilsmeier salt and stirred for 4 h . The whole progress was monitored by TLC and evaporated the solvent then followed by column chromatography column chromatography to get terminated material.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1594-58-7, N-Hydroxynicotinimidamide, and friends who are interested can also refer to it.

Reference:
Article; Su, Dongshan; Duan, Haifeng; Wei, Zhonglin; Cao, Jungang; Liang, Dapeng; Lin, Yingjie; Tetrahedron Letters; vol. 54; 50; (2013); p. 6959 – 6963;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1594-58-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1594-58-7, name is N-Hydroxynicotinimidamide. A new synthetic method of this compound is introduced below.

General procedure: To a solution of amidoxime 1 (2.5 mmol) in DMSO (2-3 mL) a cyclic anhydride 2 (2.5 mmol) was added. The reaction mixture was stirred at room temperature for 2 h. Next, to the reaction mixture powdered NaOH (5 mmol) was rapidly added and the reaction mixture was stirred at room temperature for 1 h. The reaction mixture was then diluted with cold water (30 mL) followed by the addition of hydrochloric acid to pH ~1. The resulting precipitate was filtered off, washed with cold water (25 mL) and dried in air at 50 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1594-58-7, N-Hydroxynicotinimidamide, and friends who are interested can also refer to it.

Reference:
Article; Tarasenko, Marina; Duderin, Nikolay; Sharonova, Tatyana; Baykov, Sergey; Shetnev, Anton; Smirnov, Alexey V.; Tetrahedron Letters; vol. 58; 37; (2017); p. 3672 – 3677;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1594-58-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1594-58-7, name is N-Hydroxynicotinimidamide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of heteroaromatic amidoximes 7 (7mmol) and distilled triethylamine (7mmol) in anhydrous DCM (70mL), solutions of the aromatic and heteroaromatic hydroximoyl chlorides 6 (7mmol) in the same solvent (70mL) were added dropwise. After keeping the reaction mixtures for two days at room temperature, the organic phases were washed twice with brine and dried over anhydrous Na2SO4. Upon evaporation of the solvent, the residues were submitted to chromatographic separation to isolate the desired compounds. 1,2,4-Oxadiazole-4-oxides 5Aa, 5Bb, and 5Dd are known compounds.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1594-58-7, N-Hydroxynicotinimidamide.

Reference:
Article; Memeo, Misal Giuseppe; Dondi, Daniele; Mannucci, Barbara; Corana, Federica; Quadrelli, Paolo; Tetrahedron; vol. 69; 35; (2013); p. 7387 – 7394;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem