Category: 159451-66-8

Reference of 159451-66-8, Adding some certain compound to certain chemical reactions, such as: 159451-66-8, name is N-Boc-2-Amino-5-bromopyridine,molecular formula is C10H13BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 159451-66-8.

(VI) Scheme VI: Intermediate 41: tert-butyl (5-(1-((1s,4s)-4-hydroxycyclohexyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)pyridin-2-yl)carbamate Under the protection of nitrogen, 0.218 g (0.8 mmol) of tert-butyl 2-carbamate -5-bromopyridine (Intermediate 38), 0.244 g (0.96 mmol) of bis(pinacolato)diboron, 0.234 g (2.4 mmol) of potassium acetate and 0.052 g (0.064 mmol) of [1,1-bis(di-phenylphosphino)ferrocene]palladium chloride were suspended in 15 ml of dioxane, and heated at 100 C for 2 h. The reaction was monitored by TLC. After the reaction was completed, the crude reaction solution was cooled to room temperature, added with 0.2 g (0.54 mmol) of Intermediate 40, 0.9 g (2.7 mmol) of cesium carbonate, 10 ml of dioxane, 10 ml of 2M sodium carbonate solution and 0.044 g (0.054 mmol) of [1,1-bis(di-phenylphosphino)ferrocene]palladium chloride, and heated at 110 C for 5 h. The reaction was monitored by TLC. After the reaction was completed, most of dioxane was removed from the reaction solution, and the residue was added with water and extracted with dichloromethane. The organic phases were combined, dried, and rotary evaporated to dryness to afford a crude product. The crude product was purified by preparative silica gel plate (dichloromethane/methanol =10/1, V/V) to afford a product (240 mg) as a reddish brown solid. Yield: 90.9%.

According to the analysis of related databases, 159451-66-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Forelandpharma Co. Ltd.; ZHANG, Xingmin; JI, Qi; WANG, Lei; GAO, Congmin; WANG, Ensi; DU, Zhenjian; GONG, Longlong; CHEN, Bo; (137 pag.)EP3072893; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 159451-66-8, name is N-Boc-2-Amino-5-bromopyridine, molecular formula is C10H13BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C10H13BrN2O2

To a solution of 1B (7.65 g, 28 mmol) in THF (50 mL)-MeOH (50 mL) at RT was added phenylboronic acid (6.83 g, 56 mmol), PXPd (500 mg, 0.93 mmol), followed by K2CO3 (15.5 g, 112 mmol). The reaction mixture was stirred at 70 C. in a preheated oil bath for 1 h. After this time, the reaction mixture was cooled to RT. The reaction mixture was poured into water (100 mL), and the resultant mixture was extracted with EtOAc (3¡Á100 mL). The combined organic layers were washed with saturated NaCl. The organic layer was dried (Na2SO4), filtered and concentrated. The resulting residue was purified by silica gel (120 g) column chromatography eluting with a gradient of EtOAc (0-60%) in hexane to give the title compound as an off-white solid (5.4 g, 72%). LC/MS (method A): retention time=3.07 min, (M+H)+=271.

With the rapid development of chemical substances, we look forward to future research findings about 159451-66-8.

Reference:
Patent; Sun, Chongqing; Ewing, William R.; Sulsky, Richard B.; Huang, Yanting; US2006/155126; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 159451-66-8, N-Boc-2-Amino-5-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: N-Boc-2-Amino-5-bromopyridine, blongs to pyridine-derivatives compound. Recommanded Product: N-Boc-2-Amino-5-bromopyridine

To a mixture of anhydrous CuCN (2.7 g, 30.4 mmol) in 100 mL of THF was added a solution of tert-butylmagnesium chloride (30.4 mL, 60.2 mmol, 2M solution in THF) under N2 at -78 C. After 20 minutes, tert-butyl 5-bromopyridin-2-ylcarbamate (2.1 g, 7.6 mmol, Aldrich) was added. The reaction mixture was stirred for 2 hours at -78 C. and then at room temperature for 12 hours. The mixture was quenched with saturated aqueous NH4OH and basified to pH 7 with 20% aqueous NaOH. The solid was filtered through a pad of Celite. The filtrate was extracted with ether and washed with water. The organic extract was dried over MgSO4 and concentrated. Purification by column chromatography (SiO2: 0-15% hexanes/ethyl acetate gradient) afforded 0.4 g of the title compound. MS (ESI+) m/z 251 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,159451-66-8, N-Boc-2-Amino-5-bromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem