Category: 159503-91-0

Application of 159503-91-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 159503-91-0, name is tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

2nd step: under the protection of nitrogen, the 1M isopropyl magnesium chloride-lithium chloride (88 ml, 88mmol) into the reaction bottle, temperature control -15 C to -5 C, dropwise N-Boc-1, 2, 5, 6-tetrahydro-pyridine-4-bromo, 2-methyl tetrahydrofuran (90 ml) solution, stirring finishing joining 1-2 hours. After the end of the exchange, then drop by adding isopropoxy boric acid pinacone ester (16.4g, 88mmol), subsequently maintain the reaction at room temperature overnight. Adding 10% hydrochloric acid aqueous solution quenching reaction, adjusting PH= 4-5, by adding 160 ml ethyl acetate, saturated salt water an organic layer, the organic layer after evaporation to dryness, add ethanol/heptane 5:1 obtained after pulping 18.9g N-Boc-1 needle-like white crystals, 2, 5, 6-tetrahydro-pyridine-4-boronic acid frequency that alcohol ester, GC: 99.6%, yield: 61%.

According to the analysis of related databases, 159503-91-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cangzhou Purui Oriental Technology Co., Ltd; Leng, Yanguo; Zhang, Shihong; Liu, Jinzou; (6 pag.)CN105566367; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 159503-91-0, name is tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C10H16BrNO2

In the third step, a Grignard exchange reaction of 26.21 g (0.1 mol) of N-Boc piperidin-4-enyl bromide with 12.9 g (0.105 mol) of isopropyl bromide in tetrahydrofuran, and then, under the protection of nitrogen, At 0 C, 19.03 g (0.11 mol) of pinacol methoxyboronic acid was added dropwise to the Grignard reaction solution, the reaction was held for 4 h, and then the temperature was raised to reflux for 1 h. After the reaction was completed, 10 ml of 10% dilute hydrochloric acid was added to quench the reaction. After the solvent was distilled off, 120 ml of ethanol was added for beating. The white solid was filtered to obtain 26.9 g, and the yield was 87%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 159503-91-0, tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate.

Reference:
Patent; Zhonghao (Dalian) Chemical Design Yuan Co., Ltd.; Wang Kewei; Cai Xiaochuan; Zhao Wenwu; Tang Peikun; Han Jianguo; (6 pag.)CN110526936; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 159503-91-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 159503-91-0, name is tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

2nd step: the metal lithium (1.0g, 0 . 15mol) and double (diisopropylamine) boron bromide (21.8g, 75mmol) by adding 2-methyl tetrahydrofuran (90 ml) in, temperature control -20 C to -10 C, dripping is dissolved in 2-methyl tetrahydrofuran (35 ml) of in N-Boc-1, 2, 5, 6-tetrahydro-pyridine-4-bromo (18.9g, 72mmol), stirring after 5 hours, the end of the detection reaction, adding npg (8.6g, 83mmol), heating to reflux reaction. Cooling, adding 10% hydrochloric acid aqueous solution to adjust PH= 5-6, organic layer by adding 10% palladium carbon (1.2g), after the replacement of nitrogen, filled with 1 atmospheric pressure hydrogen, after the reaction, drying of the organic layer, by adding 45 ml normal heptane cooling -10 C pulping, filtering to obtain 14.3g kind of white solid N-Boc-piperidin-4-boronic acid new pentamethylene glycol ester, GC: 98.5%, HNMR: > 98%, yield: 67%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 159503-91-0, tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate.

Reference:
Patent; Puri Cangzhou Orient Technology Co., Ltd.; Leng, Yanguo; Feng, Xuemin; Gui, Wenwu; (6 pag.)CN105566368; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem