Category: 1597-33-7

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1597-33-7, name is 2-Fluoropyridin-3-amine, molecular formula is C5H5FN2, molecular weight is 112.11, as common compound, the synthetic route is as follows.SDS of cas: 1597-33-7

To a solution of the corresponding amines (1 equiv.) in dichloromethane was added pyridine (1 equiv.) and phenyl chloroformate (1 equiv.) at 0 C. Stirring was continued for 2 h followed by the addition of the scaffold amine (1 equiv.) and DMAP (0.2 equiv.). The reaction mixture was refluxed overnight. After cooling, water was added and extracted with dichloromethane. The pooled organic fractions were brine washed, dried, concentrated and purified by Reverse Phase Prep-HPLC to provide compounds A6.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1597-33-7, 2-Fluoropyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco Gerald; SAUNDERS, Jeffrey Owen; TRAVINS, Jeremy; YAN, Shunqi; WO2014/62511; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1597-33-7, name is 2-Fluoropyridin-3-amine. A new synthetic method of this compound is introduced below., name: 2-Fluoropyridin-3-amine

A solution of 2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzoic acid (may be prepared as described in Description 79; 0.12 g, 0.34 mmol), EDC (0.16 g, 0.84 mmol) and HOBT (0.13 g, 0.84 mmol) in dimethy.formamide (2 ml) was stirred in air at room temperature for 1 h. 2-Fluoropyridin-3-amine (0.04 g, 0.37 mmol) was then added in one charge. The reaction mixture was stirred at 25 C overnight. Another batch of HOBT (0.13 g, 0.84 mmol), EDC (0. 61 g, 0.842 mmol) and 2-fluoropyridin~3-amine (0.04 g, 0.37 mmol) was added into the mixture and heating was continued at 40C for 38 hours. The reaction mixture was diluted with water (30 ml) and extracted with ethyl acetate (60 ml x 3). The organic phases were combined, washed with brine (50 ml x 3), dried over anhydrous MgS04l and concentrated. The residue was purified by chromatography (silica gel, 40 g, eluent: dichloromethane/methanol=50:1 , 1L). The solid was washed by methanol (3 ml x 2) and dried in vacuo to yield the title compound as a grey solid. 31 mg.1HNMR (400 MHz, DMSO-d6): 10.31 (s, 1 H), 8.64-8.61 (m, 3H), 8.26(d, 1 H, J=2.0), 8.04 (dd, 1H, J=2.4, 9.2), 7.97 (d, 1 H, J=4.8), 7.74 (dd, 2H, J=1.6, 4.8), 7.56 (d, 2H, J=7.2), 7.50(d,1 H, J=8.8), 7.43-7.36 (m, 4H), 5.42 (s, 2H).MS (electrospray): m/z [M+H]+ = 400.0

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1597-33-7, 2-Fluoropyridin-3-amine.

Reference:
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem