Cobalt(I)-catalyzed cocyclotrimerization of acetylene with 2,6-dicyanopyridines was written by Chelucci, Giorgio;Cabras, M. Antonietta;Saba, A.. And the article was included in Journal of Heterocyclic Chemistry in 1994.Reference of 159727-87-4 The following contents are mentioned in the article:
A procedure of general application to the synthesis of alkyl-substituted 2-cyano-6-(2-pyridyl)pyridines from alkylpyridines is outlined. Thus, [CpCo(COD)] (Cp = cyclopentadienyl, COD = 1,5-cyclooctadiene) catalyzed cocyclotrimerization of acetylene with 2,6-dicyanopyridine gave 70% 6-cyano-2,2′-bipyridine. This study involved multiple reactions and reactants, such as 2-Cyano-5-methylpyridine 1-oxide (cas: 159727-87-4Reference of 159727-87-4).
2-Cyano-5-methylpyridine 1-oxide (cas: 159727-87-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 159727-87-4