Category: 16013-85-7

Synthetic Route of 16013-85-7, Adding some certain compound to certain chemical reactions, such as: 16013-85-7, name is 2,6-Dichloro-3-nitropyridine,molecular formula is C5H2Cl2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16013-85-7.

Method for svnthesising A.4m; 2,6-dichloro-3-nitro-pyridine (2.5 g, 12.9 mmol) is taken up in a solvent mixture of THF and NMP (5:1, 13 mL), combined with two spatula tips of silicon carbide and CuCN (2.3 g, 26.0 mmol) and heated to 1800C in the microwave reactor for 45 min. Then the solid obtained is suspended in H2O, extracted with ethyl acetate, washed with NaCl-sln., the organic phase is dried on MgSO4, the solvent is eliminated in vacuo and 6-chloro-3- nitro-pyridine-2-carbonitrile (HPLC-MS: tRet. = 1.01 min, MS(M+H)+ = 182, method LCMSBASl) is obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16013-85-7, 2,6-Dichloro-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; MCCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7116; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16013-85-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16013-85-7, name is 2,6-Dichloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Reference Example 15 2,6-dibromo-3-nitropyridine 2,6-Dichloro-3-nitropyridine (5.0 g) was dissolved in 25% hydrogen bromide-acetic acid solution (50 mL), and the mixture was stirred at 80C for 6 hr. The mixture was returned to room temperature, concentrated under reduced pressure to a liquid amount of about 20 mL, neutralized using a 12N aqueous sodium hydroxide solution at 0C, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The yellow solid obtained as a residue was washed with a mixed solvent of diisopropyl ether and hexane to give the title compound as yellow crystals (yield 5.6 g, including impurity). 1H-NMR (CDCl3) delta: 7.65 (1H, d, J = 8.4 Hz), 8.03 (1H, d, J = 8.4 Hz).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16013-85-7, 2,6-Dichloro-3-nitropyridine.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1787991; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16013-85-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16013-85-7 as follows.

Intermediate 6: 2,6-dibromo-3-nitropyridine (Scheme 12); A mixture of commercially available 2,6-dichloro-3-nitropyridine (10.0 g; 51.8 mmol) and 33 w% HBr/AcOH (120 mL) is heated at 80C for 3h. The solution is concentrated in vacuo, the resulting residue is taken into EtOAc and ished with saturated aqueous sodium bicarbonate. The organic phase is dried over sodium sulfate and concentrated in vacuo. The resulting product 14.4 g (99%) is used without further purification (Intermediate 6). GC/MS: 94% purity, tR 7.56 min (tR(SM) 6.93 min), m/z (CsI^B^) 280/282/284 (M, 38), 222/224/226 (35), 76 (100) Finnegan LCQ.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16013-85-7, its application will become more common.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2006/24666; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A common compound: 16013-85-7, name is 2,6-Dichloro-3-nitropyridine,molecular formula is C5H2Cl2N2O2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 16013-85-7

At room temperature2,6-dichloro-3-nitropyridine (2.50 g) of N-methylpyrrolidone (25 mL) Copper cyanide (1) (2.32 g), and stirred at 180 C for 1 hour.After the reaction mixture was cooled to room temperature, ethyl acetate and water were added, and the mixture was filtered through celite. The filtrate was washed with saturated brine, and the aqueous layer was re-extracted with ethyl acetate. The combined organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and distilled under reduced pressure to remove the organic layer. The obtained crude product was purified by silica gel column chromatography (elution solvent: n-hexane / ethyl acetate = 90/10 to 70/30) to obtain the title compound (0.90 g).

With the rapid development of chemical substances, we look forward to future research findings about 16013-85-7.

Reference:
Patent; KISSEI PHARMACEUTICAL CO., LTD.; SHIMIZU, KAZUO; MIYAGI, TAKASHI; OHNO, KOHSUKE; UENO, YASUNORI; ONDA, YUSUKE; SUZUKI, HIKARU; (70 pag.)TW2016/5823; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding some certain compound to certain chemical reactions, such as: 16013-85-7, name is 2,6-Dichloro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16013-85-7. 16013-85-7

Prior synthesis of pyrido[3,2-d]pyrimidines utilized ethoxyethanol and aniline for substitution on 3 (Scheme 1) whereas for substituted anilines, strong bases such as LDA were used to facilitate the reaction. Both methods suffer from long durations and stringent reaction conditions, respectively. A simpler and versatile synthetic route to obtain 4-18 from 3 was envisioned using appropriate anilines at reflux in isopropanol at 120 C, a highly versatile reaction process that provided good yields (75-83%). Reduction of the nitro group was performed using iron in cone. HCl (Bechamp reduction) or using H2/Pd to give quantitative yields. Cyclization of the resultant intermediate with chlorformamidine in dimethylsulfone at 140 C provided the desired target compounds.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16013-85-7.

Reference:
Patent; DUQUESNE UNIVERSITY OF THE HOLY SPIRIT; GANGJEE, Aleem; (140 pag.)WO2017/31176; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem