Category: 1603-40-3

Related Products of 1603-40-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1603-40-3, name is 3-Methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Example 1; Synthesis of 3-amino-1-hydroxy-3,4-dihydro-1,8-naphthyridin-2(1H)-one, trifluoroacetate salt (8); 3-Methyl-2-nitropyridine (2); To a solution of H2O2 (120 g, 1.1 mol) in fuming sulfuric acid (250 mL) was added a solution of 3-methylpyridin-2-amine (1) (16 g, 0.15 mol) in concentrated sulfuric acid (50 mL) drop-wise, while keeping the reaction temperature at 0 C. After stirring for 3 h at 10-25 C., the reaction mixture was brought to pH=11-12 by adding an aqueous 40% NaOH solution at 0-5 C. The resulting mixture was extracted with ethyl acetate (3×500 mL). The combined organic layers were washed with saturated aqueous sodium chloride solution, dried over Na2SO4 and filtered. The solvent was removed in vacuo to give the desired compound (18.2 g, 89%) as a yellow oil.

According to the analysis of related databases, 1603-40-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc; US2010/324043; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1603-40-3, 3-Methylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1603-40-3, blongs to pyridine-derivatives compound. Product Details of 1603-40-3

General procedure: 3-Chlorophenyl isothiocyanate and phenyl isothiocyanate (1.9 mmol and 3.7 mmol) was dissolved in 10 mL dichloromethane at 0 C. Then aniline (2.7 mmol and 5.5 mmol), was added dropwise with constant stirring, and completion of reaction is checked by TLC analysis. After 45 min a white solid appeared, the resultant solid product was filtered, washed with hexane, triturated with 10 mL of dichloromethane and excess of hexane and dried under vacuum. Recrystallization with methanol afforded the desired solid thiourea 1-38.

The synthetic route of 1603-40-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Khan, Khalid Mohammed; Naz, Farzana; Taha, Muhammad; Khan, Ajmal; Perveen, Shahnaz; Choudhary; Voelter, Wolfgang; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 314 – 323;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1603-40-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1603-40-3, name is 3-Methylpyridin-2-amine. A new synthetic method of this compound is introduced below.

A. Preparation of (X) where Y and Z are Hydrogen A solution of 2-amino-3-methylpyridine (10.8 g) and di-tert-butyl dicarbonate (21.8 g) in tetrahydrofuran was heated under reflux for 12 hours. Evaporation afforded a solid which was recrystallized from ether-tetrahydrofuran to yield 2-(t-butoxycarbonylamino)-3-methylpyridine (10.2 g), a compound of Formula (X), m.p. 132-133 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1603-40-3, 3-Methylpyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Syntex (U.S.A.) Inc.; US5212195; (1993); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1603-40-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1603-40-3, name is 3-Methylpyridin-2-amine. A new synthetic method of this compound is introduced below.

2.4.1 Synthesis of 2-(3-methylpyridin-2-yl)isoindoline-1,3-dione (1) To a solution of phthalic anhydride (7.00 g, 47.26 mmol) in toluene (250 mL) was added 2-amino-3-picoline (5.11 g, 47.26 mmol) followed by triethylamine (5 mL). The mixture was refluxed under a Dean-Stark trap for 48 h. The cold colorless solution was evaporated and the residue was recrystallized from ethanol (60 mL) as white crystalline solid. Yield: (8.71 g, 77%). M.p.: 162-164 C. Anal. Calc. for C14H10N2O2: C, 70.58; H, 4.20; N, 11.76. Found: C, 70.21; H, 4.07; N, 11.55%. IR (cm-1) = 840 w (nu C-N), 1708 s (nus C=O), 1762 m (nuas C=O), 2871, 2920 s (nus CH2). 1H NMR (300 MHz, CDCl3): delta (ppm) = 2.21 (s, 3H, CH3), 7.23-8.42 (m, 7H, Ar-H). 13C NMR (75 MHz, CDCl3): delta (ppm) = 17.52 (CH3), 123.91-147.48 (Ar-C), 166.33 (C=O).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1603-40-3, 3-Methylpyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Article; Singh, Gurjaspreet; Saroa, Amandeep; Girdhar, Shally; Rani, Sunita; Sahoo, Subash; Choquesillo-Lazarte, Duane; Inorganica Chimica Acta; vol. 427; (2015); p. 232 – 239;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1603-40-3, name is 3-Methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H8N2

In a 250-mL round-bottomed flask, a solution of 3-methylpyridin-2-amine (4.57 g, 42.3 mmol) in AcOH (50 mL) was cooled to 0 C. NIS (9.5 g, 42 mmol, Sigma- Aldrich, India) was added in portions to the above solution at the same temperature under nitrogen atmosphere. The reaction mixture was warmed to room temperature and stirred at room temperature for 3 h. The reaction mixture was diluted with cold water (100 mL), followed by a mixture of 5% Na2S203 (40 mL) and NaHC03 (100 mL) at room temperature. The solid that formed was filtered, washed thoroughly with water and dried rigorously under reduced pressure at 50 C to give 5-iodo-3-methyl-2-pyridinamine (6.0 g) as a yellow solid.

With the rapid development of chemical substances, we look forward to future research findings about 1603-40-3.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BOURBEAU, Matthew, Paul; HONG, Fang-Tsao; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; POON, Steve, F.; STEC, Markian, M.; ST. JEAN, David, J., JR; TAMAYO, Nuria, A.; YANG, Kevin, C.; WO2013/123444; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem