Category: 1603-41-4

In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reference of 1603-41-4.

Bou-Puerto, Amelia;Bellezza, Delia;Martinez-Morro, Carlota;Gonzalez-Sanchis, Nerea;Ballesteros, Rafael;Cunat, Ana C.;Ballesteros-Garrido, Rafael research published 《 6-Amino-7-azaindole synthesis from 2,6-diaminopyridine and diols》, the research content is summarized as follows. 6-Amino-7-azaindoles were prepared by dehydrogenative condensation of 2,6-diaminopyridine with diols. In addition, the similar reactions of 2-aminopyridines gave the corresponding pyrrolo[3,2-b]pyrroles. All these transformations were performed using accessible heterogeneous catalysts (Pd/C and ZnO).

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Reference of 1603-41-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Quality Control of 1603-41-4.

Bhawale, Rajesh T.;Sarothiya, Durgesh;Kshirsagar, Umesh A. research published 《 Synergistic Approach for Decarboxylative Ortho C-H Aroylation of 2-Aryl-pyrido[1,2-a]pyrimidin-4-ones and Thiazolopyrimidinones by Merging Palladium Catalysis with Photocatalysis》, the research content is summarized as follows. A mild and efficient synergistic approach for decarboxylative aroylation of 2-aryl-pyrido[1,2-a]pyrimidin-4-ones having intrinsic directing group was developed by merging of palladium catalysis and photoredox catalysis at room temperature Therapeutically interesting aryl ketones of pyrido[1,2-a]pyrimidin-4-one was synthesized in good to excellent yield with good functional group tolerance.

Quality Control of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Recommanded Product: 2-Amino-5-methylpyridine.

Basappa, Basappa;Pookunoth, Baburajeev Chumadathil;Kempasiddegowda, Mamatha Shinduvalli;Subbegowda, Rangappa Knchugarakoppal;Lobie, Peter E.;Pandey, Vijay research published 《 Novel biphenyl amines inhibit oestrogen receptor (ER)-α in ER-positive mammary carcinoma cells》, the research content is summarized as follows. Herein, the activity of adamantanyl-tethered-biphenyl amines (ATBAs) as estrogen receptor alpha (ERα) modulating ligands is reported. Using an ERα competitor assay it was demonstrated that ATBA compound 3-(adamantan-1-yl)-4-methoxy-N-(4-(trifluoromethyl) phenyl) aniline (AMTA) exhibited an inhibitory concentration 50% (IC50) value of 62.84 nM and demonstrated better binding affinity compared to tamoxifen (IC50 = 79.48 nM). Treatment of ERα pos. (ER+) mammary carcinoma (MC) cells (Michigan Cancer Foundation-7 (MCF7)) with AMTA significantly decreased cell viability at an IC50 value of 6.4 μM. AMTA treatment of MC cell-generated three-dimensional (3D) spheroids resulted in significantly decreased cell viability. AMTA demonstrated a superior inhibitory effect compared to tamoxifen-treated MC cell spheroids. Subsequently, by use of an estrogen response element (ERE) luciferase reporter construct, it was demonstrated that AMTA treatment significantly deceased ERE transcriptional activity in MC cells. Concordantly, AMTA treatment of MC cells also significantly decreased protein levels of estrogen-regulated CCND1 in a dose-dependent manner. In silico mol. docking anal. suggested that AMTA compounds interact with the ligand-binding domain of ERα compared to the co-crystal ligand, 5-(4-hydroxyphenoxy)-6-(3-hydroxyphenyl)-7- methylnaphthalen-2-ol. Therefore, an analog of AMTA may provide a structural basis to develop a newer class of ERα partial agonists.

Recommanded Product: 2-Amino-5-methylpyridine, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Name: 2-Amino-5-methylpyridine.

Barboza, Cristina A.;Gawrys, Pawel;Banasiewicz, Marzena;Kozankiewicz, Boleslaw;Sobolewski, Andrzej L. research published 《 Substituent effects on the photophysical properties of tris(salicylideneanilines)》, the research content is summarized as follows. The role of electron acceptor/donor group substitution on the photophys. properties of tris(salicylideneanilines) (TSANs) was investigated. These compounds were synthesized and characterized through spectroscopic techniques including steady state absorption and emission spectroscopies. Their photochem. reaction mechanisms and properties were explored with the aid of ab initio methods of quantum chem. The obtained results allow us to verify the dependence of multiple emission bands on the substitution of electron donating and accepting groups to the tris(salicylideneaniline) core. The results also stress the differences in phosphorescence behavior of TSANs for which this type of emission has not been reported so far.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Name: 2-Amino-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. COA of Formula: C6H8N2.

Acharya, Swadhin Swaraj;Bhaumick, Prabhas;Kumar, Rohit;Choudhury, Lokman H. research published 《 Iodine-Catalyzed Multicomponent Synthesis of Highly Fluorescent Pyrimidine-Linked Imidazopyridines》, the research content is summarized as follows. Herein, we report a metal-free one-pot three-component reaction of aryl Me ketones, 2-aminopyridines, and barbituric acids for the synthesis of pyrimidine-linked imidazopyridines using a catalytic amount of mol. iodine in DMSO medium. This process involves a one-pot C-H oxidation, followed by the formation of one C-C and two C-N bonds. A wide variety of aryl Me ketones and 2-aminopyridines were found to be suitable for this methodol. The UV and fluorescence properties of the synthesized products were studied in water and DMSO media. Most of the synthesized products exhibited very good to excellent fluorescence quantum yield. Among all the products, compounds 4p (I) and 4q (II) showed the maximum fluorescence quantum yield (0.36) in water medium under basic conditions and compound 4c (III) showed the maximum fluorescence quantum yield (0.75) in DMSO medium.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, COA of Formula: C6H8N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1603-41-4, name is 2-Amino-5-methylpyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 1603-41-4

3.40 mL of 50% sulfuric acid (v / v) was added to a 25 mL reaction flask followed by the addition of 1.00 g (10 mmol) of 2-amino-5-methylpyridine (Compound 1), the ice salt bath was cooled to below 10 C, After a few minutes, the reaction solution became milky white; and then slowly slowly adding 1.72 g (25 mmol) of a mixture of NaNO2 and 3 mL of H2O to form a brownish-colored irritating odor gas, and the reaction solution Into a pale yellow, with 10% dilute sulfuric acid to adjust the pH to 7-8, reflux stirring reaction about 20min, spin off most of the water, to which the appropriate amount of 300 mesh silica gel, spin dry, into the glass sand core funnel, The ester was filtered and the filtrate was spin-dried to obtain the crude product (Compound 3) which was used in the next step without purification.

The synthetic route of 1603-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sichuan University; Yin, Shu-Fan; Li, Yong; Cao, Tingting; Yang, Ziyao; (16 pag.)CN105998016; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1603-41-4 ,Some common heterocyclic compound, 1603-41-4, molecular formula is C6H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-amino 5-methyl pyridine (5.0 g) was cooled to 5°C and Con. HCI (90 mL) was added. Sodium nitrite (5.16 g) was added portion wise slowly to the reaction mixture in 15 minutes. The reaction mixture was allowed to warm to 30°C and stirred for 1 .5 hours at the same temperature. Cooled the reaction mixture to 5°C and 40percent aqueous sodium hydroxide solution (150 mL) was added and pH adjusted to 13. Extracted the reaction mixture with ethyl acetate (3 x 50 mL) and washed the combined organic layer with brine solution (50 mL). The solution was dried over sodium sulfate and evaporated the solvent under reduced pressure to afford crude compound. The crude product was purified by column (0376) chromatography using 60-120 silica mesh and (10percent to 20percent) ethyl acetate / hexane as eluent to obtain title compound as colorless liquid. Yield: 2.62 g; Purity by HPLC: 99.97percent

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1603-41-4, its application will become more common.

Reference:
Patent; DR. REDDY?S LABORATORIES LIMITED; DAHANUKAR, Vilas Hareshwar; ORUGANTI, Srinivas; RAO, Pallavi; CHAKKA, Ramesh; BAIG, Mohammed Azeezulla; VYALA, Sunitha; SALADI, Venkata Narasayya; PEDDY, Vishweshwar; ELATI, Raviram Chandrasekhar; MOHANARANGAM, Saravanan; RAJ, Gopal; MAMIDIPALLI, Phani; (73 pag.)WO2017/175161; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1603-41-4 as follows., 1603-41-4

Water (20 mL),3-Chloro-4- (4-methylphenyl) -4-oxobutanoic acid(5.02 g, 0.022 mol),2-Amino-5-methylpyridine (3) (3.58 g, 0.033 mol)And sodium carbonate (2.33 g, 0.022 mol) were successively added to a 100 mL reaction flask,After mixing,Slowly warmed to 80 internal temperature, nitrogen protection,Insulation reaction 7h, stop the reaction.With 6N hydrochloric acid pH = 0.5 ~ 1, Stirred at room temperature for 30min,No change in pH after the test, adding an equal amount of ethyl acetate,Stir 15min, points to the reservoir,Water layer plus activated carbon 0.1g, 50 decolorization 30min, hot filtration,The filtrate was adjusted to pH = 3.0 ~ 3.5 with 6N aqueous sodium hydroxide solution to precipitate a solid,Cooling to 0 ~ 5 insulation 1h, suction filtration, the filter cake with 10mL ice water rinse,80 vacuum drying 6h,3.21 g of pale yellow solid (HPLC: 97.6%) was obtained in a yield of 52.0%.

The chemical industry reduces the impact on the environment during synthesis 1603-41-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; East China University of Science and Technology; Zhao Jianhong; Guan Yu; Liao Fan; Deng Weiping; Shi Xiaoxin; Zhao Jinyuan; Ma Lirong; Chen Chunyan; Yang Jun; Li Jie; Lei Qingyun; (11 pag.)CN107383005; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem