1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Computed Properties of 1603-41-4
Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Computed Properties of 1603-41-4.
Liu, Chao;Li, Yining;Sheng, Ren;Han, Xiaowan;Bao, Li;Wang, Chenyin;Wang, Weizhi;Jiang, Xinhai;Han, Jiangxue;Lei, Lijuan;Li, Ni;Zhang, Jing;Chen, Minghua;Li, Yan;Wu, Yexiang;Li, Shunwang;Ren, Yu;Xu, Yanni;Si, Shuyi research published 《 Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis》, the research content is summarized as follows. Herein, 36 derivatives of E09241 I [X = N, O,methylamino; R1 = H, 5-Me, 5-Cl etc.; R2 = Ph, 3-pyridyl, 4-methyl-2-pyridyl etc.] were prepared The synthesis, up-regulation of OPG activities, SAR (structure-activity relationship) and cytotoxicity of these compounds I were presented. Compounds with good up-regulating OPG activities was inhibited RANKL (the receptor activator of nuclear factor-kappa B ligand)-induced osteoclastogenesis in RAW264.7 cells. Particularly, compounds I [X = N; R1 = 5-Me; R2 = 4-methyl-2-pyridyl, 4-cyclopropyl-2-pyridyl] significantly reduced NFATc1 and MMP-9 protein expression through inhibition of the NF-κB and MAPK pathways in RANKL induced RAW264.7 cells. In addition, compounds I [X = N; R1 = 5-Me, 5-Cl; R2 = 4-methyl-2-pyridyl, 4-cyclopropyl-2-pyridyl, 2-phenylethyl] significantly promoted osteoblast differentiation in MC3T3-E1 cells in osteogenic medium and compounds I [X = N; R1 = 5-Me, 5-Cl; R2 = 4-methyl-2-pyridyl, 4-cyclopropyl-2-pyridyl, 2-phenylethyl, 4-cyclopropyl-2-pyridyl] obviously increased OPG protein expression and secretion in MC3T3-E1 cells. Furthermore, the pharmacokinetic profiles, acute toxicity and hERG K+ channel effects of compounds I [X = N; R1 = 5-Me, 5-Cl, 5-Br; R2 = 4-methyl-2-pyridyl, 4-cyclopropyl-2-pyridyl, 2-phenylethyl, 4-cyclopropyl-2-pyridyl] were investigated. Taken together, these results indicated that N-methylpyridine-chlorofuranformamide analog I [X = N; R1 = 5-Me; R2 = 4-cyclopropyl-2-pyridyl] was served as a promising lead for the development of new agents for treating osteoporosis.
1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Computed Properties of 1603-41-4
Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem