Synthetic Route of 160599-70-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160599-70-2, name is 2,5-Dibromo-3-chloropyridine, molecular formula is C5H2Br2ClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A 100-mL pressure vessel was charged with 4,4,5, 5-tetramethyl-2-(4- (phenylsulfonyl)phenyl)-l,3,2-dioxaborolane (6.34 g, 18.43 mmol), 2,5-dibromo- 3-chloropyridine (5.00 g, 18.43 mmol, Sigma-Aldrich, St. Louis, MO), potassium carbonate (7.64 g, 55.3 mmol), tetrakis(triphenylphosphine)palladium (1.06 g, 0.92 mmol, Strem Chemical Inc, Newburyport, MA), 20 mL of 1,2- dimethoxy ethane, and 4 mL of water. The vessel was sealed and the reaction mixture was heated at 100 C for 8 h. After cooling to room temperature, the mixture was diluted with EtOAc (30 mL) and water. The layers were separated and the organic phase was dried (MgS04), filtered, and concentrated under a vacuum to give an oil. Purification via column chromatography (40 g of silica gel, 0 to 50% EtOAc in hexanes) produced 5-bromo-3-chloro-2-(4- (phenylsulfonyl)phenyl)pyridine (2.56 g) as a tan solid.
According to the analysis of related databases, 160599-70-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; ASHTON, Kate; BOURBEAU, Matthew, Paul; HONG, Fang-Tsao; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; POON, Steve, F.; STEC, Markian, M.; ST. JEAN, David, J., JR; TAMAYO, Nuria, A.; YANG, Kevin, C.; WO2013/123444; (2013); A1;,
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