Category: 16063-70-0

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 16063-70-0, Name is 2,3,5-Trichloropyridine, SMILES is ClC1=CN=C(Cl)C(Cl)=C1, in an article , author is Cai, Yimin, once mentioned of 16063-70-0, Safety of 2,3,5-Trichloropyridine.

Highly efficient actinide(III)/lanthanide(III) separation by novel pillar[5] arene-based picolinamide ligands: A study on synthesis, solvent extraction and complexation

Selective extraction of highly radiotoxic actinides(III) is an important and challenging task in nuclear wastewater treatment. Many proposed ligands containing S or P atoms have drawbacks including high reagent consumption and possible secondary pollution after incineration. The present work reports five novel pillar[5]arene-based extractants that are anchored with picolinamide substituents of different electronic nature by varying spacer. These ligands reveal highly efficient separation of actinides(III) over lanthanides(III). Specifically, almost all of these ligands could extract Am(III) over Eu(III) selectively at around pH 3.0 (SFAm/Eu > 11) with fast extraction kinetics. Variation of the pyridine nitrogen basicity via changing para-substitution leads to an increase in the distribution ratios by a factor of over 300 times for Am(III) with an electron-withdrawing group compared to those with an electron donating group. Investigation of complexation mechanism by slope analysis, NMR, IR, EXAFS, and DFT techniques indicates that each ligand binds two metal ions by pyridine nitrogen and amide oxygen. Finally, these ligands do not show obvious decrease in both extraction and separation ability after being exposed to 250 kGy absorbed gamma radiation. These results demonstrate the potential application of pillar[5] arene-picolinamides for actinide(III) separation.

Interested yet? Read on for other articles about 16063-70-0, you can contact me at any time and look forward to more communication. Safety of 2,3,5-Trichloropyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 16063-70-0, Name is 2,3,5-Trichloropyridine. In a document, author is Mohammadi, Abdorreza, introducing its new discovery. Quality Control of 2,3,5-Trichloropyridine.

Heterocyclic aromatic amines in doner kebab: Quantitation using an efficient microextraction technique coupled with reversed-phase high-performance liquid chromatography

The safety of doner kebab as a traditional Middle East tasty food can threaten via the formation of dangerous compounds such as heterocyclic aromatic amines during heat process. In this regard, the current investigation was devoted to measuring of 4 HAAs (2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)) in doner kebab samples with an innovative microextraction technique combined with high-performance liquid chromatography. The limit of detection was in the range of 4.8 and 5.3 ng/g, while relative standard deviations were between 6.5% and 8.3%, and recoveries were calculated in the range of 89%-97%. The most and the least total mean values of HAA levels were 13.30 ng/g for MeIQx and 5.0 ng/g for IQ. The proposed method showed a high capability to extract trace amount of HAAs from a complex matrix such as doner kebab. Also, this technique is easy, high sensitive, selective, accurate and efficient.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 16063-70-0 help many people in the next few years. Quality Control of 2,3,5-Trichloropyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16063-70-0, Name is 2,3,5-Trichloropyridine, molecular formula is C5H2Cl3N, belongs to pyridine-derivatives compound. In a document, author is Petrova, P. R., introduce the new discover, COA of Formula: C5H2Cl3N.

Conjugates of 9-and 11-Halo-Substituted Cytisines with 1 ‘-N-Methylurocanic Acid

New (-)-cytisine derivatives were synthesized by conjugating 9- and 11-halo-substituted cytisines with 1 ‘-N-methylurocanic acid using N-hydroxysuccinimide.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 16063-70-0. COA of Formula: C5H2Cl3N.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Related Products of 16063-70-0, Adding some certain compound to certain chemical reactions, such as: 16063-70-0, name is 2,3,5-Trichloropyridine,molecular formula is C5H2Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16063-70-0.

To 30.74 g of potassium tert-butoxide in 100 ml of dimethylsulfoxide, 16.72 g of nitromethane was added dropwise with stirring under cooling with ice, and after the addition, the mixture was stirred at room temperature for another 1 hour. Then, the reaction mixture was cooled with ice again, and to the reaction mixture, 25.00 g of 2,3,5-trichloropyridine in 100 ml of dimethylsulfoxide was added dropwise with stirring, and after the addition, the mixture was stirred at 70 C. for another 6 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, poured into 200 ml of 10% aqueous hydrochloric acid with stirring under cooling with ice and extracted with ethyl acetate (200 ml¡Á1). The resulting organic layer was washed with water (100 ml¡Á1) and dried over saturated aqueous sodium chloride and then anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 5:95 to 10:90) as the eluent to obtain 10.10 g of the desired product as a pale yellow oil

According to the analysis of related databases, 16063-70-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES LIMITED; Iwasa, Motoyoshi; Tomizawa, Mitsutaka; Tsuji, Keisuke; Nakamura, Toshiyuki; Mita, Takeshi; Kuwahara, Hidehito; asahi, Miho; Imanaka, Hotaka; (342 pag.)JP2016/11286; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 16063-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16063-70-0, name is 2,3,5-Trichloropyridine. A new synthetic method of this compound is introduced below.

At room temperature, 2,3,5-trichloropyridine (20 g, 109 mmol) and 2-methoxyphenylboronic acid (21.5 g, 141.7 mmol) are added to a 2-neck flask.Pd (PPh 3) 4 (5.04 g, 5.67 mmol) and potassium fluoride (15.8 g, 272.5 mmol) are added.After addition of 300 ml of toluene, the mixture was stirred at 100 C for 5 hours. After completion of the reaction, the solution is filtered through silica.Column chromatography after solvent removal (MC: Hexane = 1: 1)After purification, an oil type transparent compound S-1 (32.6 g, yield 90%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16063-70-0, its application will become more common.

Reference:
Patent; Doosan Co., Ltd; Shin Hwan-gyu; Park Jeong-geun; (76 pag.)KR2019/76376; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16063-70-0, name is 2,3,5-Trichloropyridine. A new synthetic method of this compound is introduced below., Product Details of 16063-70-0

23.7 g of the above product, 20 g of TCP, 15 g of anhydrous potassium carbonate, and 22 ml of dimethyl sulfoxide were mixed and stirred at 120 C for 4 h.After the reaction mixture was cooled, water and benzene were layered, and the organic phase was separated and washed with 1N aqueous sodium hydroxide.After drying over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure to give a pale yellow crystalline solid.Recrystallization from n-hexane-ethyl acetate gave a white crystalline solid.M.p. 105.5-107 C, the total yield was 50.1%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16063-70-0, 2,3,5-Trichloropyridine.

Reference:
Patent; Hunan Qiwei Technology Co., Ltd.; Zhu Shefeng; Cheng Wangsheng; (6 pag.)CN108440516; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16063-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16063-70-0, name is 2,3,5-Trichloropyridine. A new synthetic method of this compound is introduced below.

Step 1 : In a sealed tube, 2,3,5-trichloro pyridine (8.0 g, 44mmol), 4-chloro aniline (6.17 g, 49 mmol), triphenyl phosphine (1.16 g, 44 mmol) and sodium-te/t-butoxide (5.09 g, 53mmol) were mixed in c-xylene (80 mL). The resulting mixture was purged with argon, added Pd(OAc)2 (0.49 g, 2.2mmol) and heated at 110 C for 12 h. After completion of the reaction, the reaction mixture was filtered through celite bed and concentrated under vacuum. The residue obtained was diluted with ethyl acetate (200 mL), washed with water, brine solution and dried over anhydrous Na2S04. The organic phase was concentrated and purified by the column chromatography (60-120 size mesh) to get the yellow solid 3,5-dichloro-//-(4-chlorophenyl)pyridin-2-amine (7.0 g, 58.23%). LCMS: (Method B) 275 (M+H), RT. 3.69 min, 1H NMR (400 MHz, DMSO-d6) : delta 8.68 (s, 1H), 8.14 (d, J = 2.28 Hz, 1H), 8.04 (d, J = 2.32 Hz, 1H), 7.68-7.66 (m, 2H), 7.34-7.32 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16063-70-0, 2,3,5-Trichloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; SPANGENBERG, Thomas; (129 pag.)WO2016/827; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 16063-70-0, 2,3,5-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16063-70-0, blongs to pyridine-derivatives compound. 16063-70-0

To a solution of ethyl (2E) -3- [2-hydroxy-4- (2- methoxyethoxy) phenyl] acrylate (900 mg) in N,N- dimethylformamide .(15 ml) was added sodium hydride (60% in oil, 188 mg) , and the mixture was stirred at room temperature for 1 hr. 2, 3, 5-Trichloropyridine (925 mg) was added to the reaction mixture, and the. mixture was stirred at 800C for 36 hr. After cooling, water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) , and concentrated. The obtained residue was subjected to silica EPO gel column chromatography, and eluted with ethyl acetate- hexane (1:4, v/v) . The obtained crude crystals were recrystallized from ethyl acetate-hexane to give ethyl (2E) -3- [2- [ (3, 5-dichloropyridin-2-yl) oxy] -4- (2- methoxyethoxy) phenyl] acrylate (1.01 g, yield: 72%) as colorless crystals, melting point 70.7-71.30C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16063-70-0, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some common heterocyclic compound, 16063-70-0, molecular formula is C5H2Cl3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.16063-70-0

400 g of sulfolane and 400 g of dimethylsulfoxide were weighed into a 1000 mL flask and dehydrated to a temperature of less than 0.05% at 200 C under a pressure of 0.07 MPa (negative pressure)96 g (1.66 mol) of cesium fluoride, 96 g (1.66 mol) of potassium fluoride, 120 g (0.67 mol) of trichloropyridine, 2 g of 18-crown ether and 3 g of potassium carbonate were weighed into a reaction flask at 120 C and heated to 200 C The product was collected in about 3 hours. 95 g (0.51 mol) of the product was obtained in 90% yield. The purity was 96.8% as determined by gas chromatography.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16063-70-0.

Reference:
Patent; Weixun Chemical (Nanjing) Co., Ltd; Wang, Faqiang; (4 pag.)CN106008329; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16063-70-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16063-70-0, name is 2,3,5-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of /e/ – butyl N-(2-amino-5-fluoro-phenyl)-N-methyl-carbamate (142.0 g, 0.591 mol) and 2,3,5-trichloropyridine (108.0 g, 0.591 mol) in dioxane (2.0 L) was added CS2CO3 (385.0 g, 1.18 mol). The mixture was degassed with nitrogen for 2 min before Pd(OAc)2 (13.3 g, 0.059 mol) and BINAP (73.5 g, 0.118 mol) were addedunder nitrogen. After the charging was completed, the suspension was heated to 110 C and stirred for 3 h. After TLC (petrolieum ether:EtOAc = 20 : 1) showed the reaction was completed, the reaction mixture was cooled back to r.t., diluted with EtOAc (3.0 L) and filtered. The filtrate was concentrated in vacuo to give a crude product, which was purified by silica gel flash chromatography (petroleum ether:EtOAc = 500 : 1 ~ 20 : 1) to give ieri-butyl N-[2-[(3,5-dichloro-2-pyridyl)amino]-5-fluoro- phenyl]-N-methyl-carbamate (190.0 g, 83.2% yield) as a white solid. MS (ESI): 385.9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16063-70-0, 2,3,5-Trichloropyridine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Xiao; LIU, Yongqiang; SHEN, Hong; SHI, Houguang; TAN, Xuefei; ZHOU, Chengang; ZHOU, Mingwei; (163 pag.)WO2020/64661; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem