Category: 16063-70-0

16063-70-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16063-70-0, name is 2,3,5-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 8 850 g of sulfolane, 204.3 g (3.3 mol) of potassium fluoride/cesium fluoride (9:1), 7.5 g of potassium carbonate and 20.4 g of tetra-n-octylphosphonium bromide as the phase transfer catalyst were azeotropically dried by removal of about 100 g of sulfolane by distillation (170¡ã C.). 273.5 g (1.5 mol) of 2,3,5-trichloropyridine were then added at 190¡ã C. and the reaction mixture was heated to 215¡ã C. After about 2 h reflux commenced. This was maintained for 20 h, and all the substance which boiled below 3 mm Hg/140¡ã C. was then removed from the reaction mixture by distillation. A first fraction (15.8 g) which contained 14.2 g of 5-chloro-2,3-difluoropyridine and 1.3 g of 3,5-dichloro-2-fluoropyridine (determined by GC by means of internal standard) was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16063-70-0, 2,3,5-Trichloropyridine.

Reference:
Patent; Hoechst Aktiengesellschaft; US5468863; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16063-70-0, Adding a certain compound to certain chemical reactions, such as: 16063-70-0, 2,3,5-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16063-70-0, blongs to pyridine-derivatives compound.

40.0 g of 2,3,5-trichloropyridine was dissolved in 240 g of dimethyl sulfoxide.65.2 g of methyl cyanoacetate and 75.8 g of potassium carbonate were sequentially added to the reaction solution.The reaction was stirred at 120 C. for 7.5 hours.After completion of the reaction, the reaction solution was cooled to 40 C., and 200 g of water and 114 g of 35 mass% hydrochloric acid were added to the reaction solution.The reaction was stirred at room temperature for 1 hour.The solid precipitated in the reaction solution was separated by filtration.The obtained solid was washed sequentially with 50 g of water, 50 g of normal hexane, and 100 g of diisopropyl ether, and then dried under reduced pressure to obtain 41.8 g of the desired product as a yellow solid (yield: 77.7%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16063-70-0, its application will become more common.

Reference:
Patent; Nissan Chemical Industries, Ltd.; Nakayama, Yosuke; Saito, Fumiyo; Nanju, Yusuke; (53 pag.)JP2019/34892; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16063-70-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16063-70-0, name is 2,3,5-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of 4a (74.5 g, 410 mmol) in DMF (450 mL) was added NaH (60% dispersion in oil, 19.7 g, 491 mmol) at 0 C and the mixture was stirred at the temperature for 30 min. Then 2,3-dichloro-5-(trifluoromethyl)pyridine (60.0 mL, 433 mmol) was added to the mixture, which was allowed to warm to room temperature, and stirred at room temperature for 1 h and at 50 C for 1 h. The reaction was quenched with sat. NH4Cl on ice-bath and extracted with EtOAc and the combined organic layer was washed with water and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residual solid was purified by silica gel chromatography (hexane-EtOAc, 9:1 to 2:1) to give a pale-yellow solid, which was recrystallized from EtOAc/hexane to give 5a (79.0 g, 53%) as white crystals.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16063-70-0, 2,3,5-Trichloropyridine.

Reference:
Article; Rikimaru, Kentaro; Wakabayashi, Takeshi; Abe, Hidenori; Tawaraishi, Taisuke; Imoto, Hiroshi; Yonemori, Jinichi; Hirose, Hideki; Murase, Katsuhito; Matsuo, Takanori; Matsumoto, Mitsuharu; Nomura, Chisako; Tsuge, Hiroko; Arimura, Naoto; Kawakami, Kazutoshi; Sakamoto, Junichi; Funami, Miyuki; Mol, Clifford D.; Snell, Gyorgy P.; Bragstad, Kenneth A.; Sang, Bi-Ching; Dougan, Douglas R.; Tanaka, Toshimasa; Katayama, Nozomi; Horiguchi, Yoshiaki; Momose, Yu; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3332 – 3358;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16063-70-0 as follows., 16063-70-0

767 mg of ethyl 2-cyanopropionate and then 833 mg of potassium carbonate were added to a solution of 500 mg of 2,3,5-trichloropyridine in 5 ml of dimethyl sulfoxide.The reaction was stirred at 100 C. for 5 hours.After completion of the reaction, the reaction solution was cooled to room temperature, 10 ml of water was added, and the mixture was partitioned with 20 ml of ethyl acetate.The obtained organic layer is concentrated under reduced pressure, and the obtained residue is purified by silica gel chromatography (ethyl acetate: hexane = 1: 2)Thus, 270 mg of the desired product was obtained as a colorless oil (yield 49%).

The chemical industry reduces the impact on the environment during synthesis 16063-70-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nissan Chemical Industries, Ltd.; Nakayama, Yosuke; Saito, Fumiyo; Nanju, Yusuke; (53 pag.)JP2019/34892; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem