Category: 16098-21-8

Related Products of 16098-21-8, Adding some certain compound to certain chemical reactions, such as: 16098-21-8, name is 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one,molecular formula is C6H5BrN2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16098-21-8.

A mixture containing 0.40 g (1.72 mmol) of 3-bromo-1- methyl-5-nitropyridin-2(lH)-one, 0.39 g (2. 60 mmol) of 2,4- dimethylphenyl boronic acid, 0.70 g (5.06 mmol) of potassium carbonate, 0.31 ml (17.22 mmol) of water, and 0.99g (0.86 mmol) of tetrakis(triphenylphosphine)palladium(0) in 80 ml of dioxane was heated to 90C under a nitrogen atm. overnight. The reaction was cooled to room temperature, diluted with ethyl acetate and washed with saturated sodium bicarbonate. The organic phase was dried over magnesium sulfate. Filtration, removal of solvent and purification of the residue via biotage eluting with 60% ethyl acetate/hexanes gave 0 . 37 g (82.55%) of product. ¹H NMR (CDC13) 5: 2.19 (s, 3H) , 2.35 (s, 3H) , 3.71 (s, 3H) , 7.03 – 7 . 09 (m, 3H) , 8 . 06 (d, J = 3.2 Hz, 1H) , 8 . 66 (d, J = 3.2 Hz, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16098-21-8, 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/99688; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16098-21-8, name is 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one

To a stirred solution of 3-bromo-l-methyl-5-nitropyridin-2(lH)-one (2.1 g, 9.012 mmol, 1.0 eq) and potassium (5-chloro-2-fluorophenyl)trifluoroborate (3.2 g, 13.518 mmol, 1.5 eq) in dioxane (50 mL) was added a 2M solution of Na2C03 (1.91 g, 18.024 mmol, 2.0 eq) in H20 at RT. The resulting mixture was purged with nitrogen for 10 min followed by addition of Pd(dppf)Cl2.DCM (0.368 g, 0.450 mmol, 0.05 eq), again purged with nitrogen for 10 min. The reaction mixture was heated at l00C for overnight. The progress of reaction was monitored by LCMS. The reaction mixture was diluted with water (50 mL), extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with water (50 mL), with brine (50 mL), dried over Na2S04, concentrated and purified by combi flash chromatography [silica gel 100-200 mesh: elution 0-30 % EtOAc in Hexane] to afford the desired compound 3-(5-chloro-2-fluorophenyl)-l-methyl-5-nitropyridin-2(lH)-one (1.6 g, 62.99%) as off white solid. LCMS: (M+l)+: 283.2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16098-21-8, 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one.

Reference:
Patent; INTEGRAL BIOSCIENCES PVT. LTD.; PUJALA, Brahmam; PENDHARKAR, Dhananjay; AGARWAL, Anil Kumar; KUMAR, Varun; ARYA, Satish Kumar; CHAKRAVARTY, Sarvajit; (0 pag.)WO2020/12357; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 16098-21-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16098-21-8, name is 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one, molecular formula is C6H5BrN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution containing 0.60 g (2.57 mmol) of 3- bromo-1-methyl-5-nitropyridin-2 (1H)-one in 120 ml of toluene under a nitrogen atmosphere was added 0.64 ml (5.15 mmol) of 2,4-dimethylaniline, 1.61 g (2.57 mmol) of rac- 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (racemic BINAP), 0.37 g (3.85 mol) of sodium t-butoxide and 1.20 g (1.31 mmol) of tris(dibenzylideneacetone)dipalladium (0). The reaction was heated to 95C overnight. The reaction was cooled to room temperature, diluted with ethyl acetate and washed with saturated sodium bicarbonate. The organic phase was dried over magnesium sulfate. Filtration, removal of solvent and purification of the residue via biotage eluting with 60% ethyl acetate/hexanes gave the desired product with some starting aniline. The material was triturated with hexanes and the solids filtered and dried to afford 0.154 g (21.9%) of product. ¹H NMR (CDC13) 5: 2.22 (s, 3H) , 2.35 (s, 3H) , 3.74 (s, 3H) , 6.72 (bs, 1H), 7 .06 – 7.18 (m, 4H), 8. 06 (d, J = 2.8 Hz, 1H)

According to the analysis of related databases, 16098-21-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/99688; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 16098-21-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16098-21-8, name is 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one, molecular formula is C6H5BrN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution containing 0.60 g (2.57 mmol) of 3- bromo-1-methyl-5-nitropyridin-2 (1H)-one in 120 ml of toluene under a nitrogen atmosphere was added 0.64 ml (5.15 mmol) of 2,4-dimethylaniline, 1.61 g (2.57 mmol) of rac- 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (racemic BINAP), 0.37 g (3.85 mol) of sodium t-butoxide and 1.20 g (1.31 mmol) of tris(dibenzylideneacetone)dipalladium (0). The reaction was heated to 95C overnight. The reaction was cooled to room temperature, diluted with ethyl acetate and washed with saturated sodium bicarbonate. The organic phase was dried over magnesium sulfate. Filtration, removal of solvent and purification of the residue via biotage eluting with 60% ethyl acetate/hexanes gave the desired product with some starting aniline. The material was triturated with hexanes and the solids filtered and dried to afford 0.154 g (21.9%) of product. ¹H NMR (CDC13) 5: 2.22 (s, 3H) , 2.35 (s, 3H) , 3.74 (s, 3H) , 6.72 (bs, 1H), 7 .06 – 7.18 (m, 4H), 8. 06 (d, J = 2.8 Hz, 1H)

According to the analysis of related databases, 16098-21-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/99688; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem