Category: 16133-25-8

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Electric Literature of 16133-25-8.

Kan, Chun;Shao, Xiaotao;Wu, Linyun;Zhang, Yao;Bao, Xiaofeng;Zhu, Jing research published 《 A novel “OFF-ON-OFF” fluorescence chemosensor for hypersensitive detection and bioimaging of Al(III) in living organisms and natural water environment》, the research content is summarized as follows. High-selectivity detection of trace Al³⁺ ions in water and biol. systems by a fluorescence imaging method is not yet mature. Herein, we synthesized a novel reversible Al³⁺-specific fluorescent probe named RBLF by linking Rhodamine B and pyridine-3-sulfonyl chloride through o-phenylenediamine in several reactions. RBLF exhibited an ultra-high sensitive and excellent selective response towards Al³⁺ by fluorescence and UV-vis spectra in aqueous solutions What is more worth mentioning is that its response is fast, dual changes in color and fluorescence of the probe solution that can occur instantaneously after adding with Al³⁺. Its detection limit for Al³⁺ ions in aqueous system solutions is 14.23 nM, which is far below the maximum allowable amount of Al³⁺ in drinking water. Moreover, the probe provided an effective method for detecting low concentrations of Al³⁺ in natural water, living cells, zebrafish and plant tissues.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Electric Literature of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Category: pyridine-derivatives.

Abdelsamie, Ahmed S.;Salah, Mohamed;Siebenbuerger, Lorenz;Merabet, Ahmed;Scheuer, Claudia;Frotscher, Martin;Mueller, Sebastian T.;Zierau, Oliver;Vollmer, Guenter;Menger, Michael D.;Laschke, Matthias W.;van Koppen, Chris J.;Marchais-Oberwinkler, Sandrine;Hartmann, Rolf W. research published 《 Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis》, the research content is summarized as follows. Osteoporosis is predominantly treated with drugs that inhibit further bone resorption due to estrogen deficiency. Yet, osteoporosis drugs that not only inhibit bone resorption but also stimulate bone formation, such as potentially inhibitors of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), may be more efficacious in the treatment of osteoporosis. Blockade of 17β-HSD2 is thought to increase intracellular estradiol and testosterone in bone, thereby inhibiting bone resorption by osteoclasts and stimulating bone formation by osteoblasts, resp. We here describe the design, synthesis, and biol. characterization of a novel bicyclic-substituted hydroxyphenylmethanone 17β-HSD2 inhibitor (I). Compound I is a nanomolar potent inhibitor of human 17β-HSD2 (IC₅₀ of 6.1 nM) and rodent 17β-HSD2 with low in vitro cellular toxicity, devoid of detectable estrogen receptor α affinity, displays high aqueous solubility and in vitro metabolic stability, and has an excellent oral pharmacokinetic profile for testing in a rat osteoporosis model. Administration of I in a rat osteoporosis model demonstrates its bone-sparing efficacy.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 16133-25-8, Pyridine-3-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H4ClNO2S, blongs to pyridine-derivatives compound. Formula: C5H4ClNO2S

5- (2-fluorophenyl) pyrrole-3-carbaldehyde 10g, 4- dimethylaminopyridine 1.3g, triethylamine 7.5g and acetonitrile (40ml) added to the reaction flask, stirred at room temperature; pyridine-3-sulfonyl chloride 11.3g and acetonitrile (10ml), the reaction flask was added dropwise; the reaction was heated to 45 1.5 hours; cooled to 25 , was added water (30ml); the system with concentrated hydrochloric acid adjusted to ph 4-5, stirred for half an hour at 25 deg.] C; was cooled to 0-5 deg.] C stirred for 1 hour; the filter cake with acetonitrile: water (1: 2) 30ml rinsed again with water (20ml) was rinsed 2 times, 50 deg.] C and dried in vacuo to give 5- (2-fluorophenyl yl) -1- (pyridin-3-sulfonyl) pyrrole-3-carbaldehyde 15g;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16133-25-8, Pyridine-3-sulfonyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang Sincerity Pharmaceutical Co., Ltd.; Mao Liping; (9 pag.)CN104860926; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 16133-25-8, Pyridine-3-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16133-25-8, blongs to pyridine-derivatives compound. Recommanded Product: 16133-25-8

Reference Example 23; tert-butyl { [5-bromo-l- (pyridin-3-ylsulfonyl) -lH-pyrrol-3- yl]methyl }methylcarbamate; To a suspension of sodium hydride (60percent in oil, 7.4 g) in tetrahydrofuran (300 mL) was added a solution of tert-butyl [ (5-bromo-lH-pyrrol-3-yl) methyl]methylcarbamate (44.5 g) in tetrahydrofuran (60 mL) at 0°C, and 15-crown-5 (40.7 g) and pyridine-3-sulfonyl chloride (30.1 g) were added at the same temperature. The mixture was stirred at room temperature for 30 min, water was added and the mixture was concentrated under reduced pressure. The residue was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was washed with a mixed solvent of diisopropyl ether-hexane=l : 1 to give the title compound as colorless crystals (yield 45.2 g, 68percent) . 1H-NMR (CDCl3) delta: 1.47(9H,s), 2.80 (3H,brs) , 4.18 (2H,brs) ,6.28(lH,brs) , 7.35 (lH,brs) , 7.48-7.52 (IH,m) , 8.18-8.22 (lH,m) , 8.85-8.88 ( IH,m), 9.12-9.13 (IH, m) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16133-25-8, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/108380; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16133-25-8, name is Pyridine-3-sulfonyl chloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H4ClNO2S

To a solution of (6-phenylpyridazin-3-ylmethyl)amine hydrochloride (121 mg) (containing 0.458 mmol of a pure content) obtained in Reference Example 2-(c) in methylene chloride (1 ml) were added triethylamine (0.26 ml, 1.8 mmol) and 3-pyridylsulfonyl chloride (see The Journal of Organic Chemistry, 54, 389 (1989)) (83.2 mg, 0.468 mmol), followed by stirring at room temperature for 17 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure, and water was added to the residue, followed by extraction with ethyl acetate. The separated organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (eluent; ethyl acetate_acetonitrile=1:00:1 (V/V), then chloroform), and fractions containing the desired compound were concentrated under reduced pressure to afford the title compound (130 mg) as a slightly brown solid. (Yield: 87percent) Mass spectrum (CI, m/z): 327 (M++1). 1H-NMR spectrum (CDCl3, ppm): 9.11 (dd, J=2.4, 0.9Hz, 1H), 8.75 (dd, J=4.8, 1.6Hz, 1H), 8.19 (ddd, J=8.1, 2.4, 1.6Hz, 1H), 8.05-8.00 (m, 2H), 7.82 (d, J=8.8Hz, 1H), 7.56-7.49 (m, 4H), 7.42 (ddd, J=8.1, 4.8, 0.9Hz, 1H), 6.30 (brs, 1H), 4.57 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 16133-25-8.

Reference:
Patent; Ube Industries, Ltd.; EP2264009; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 16133-25-8, Pyridine-3-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H4ClNO2S, blongs to pyridine-derivatives compound. COA of Formula: C5H4ClNO2S

4-(a) tert-Butyl (tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate To 14 ml of a methylene chloride solution containing 640 mg (3.60 mmol) of 3-pyridylsulfonyl chloride were added 1.20 g (3.56 mmol) oftert-butyl [(6-aminomethylpyridin-2-yl)tert-butoxycarbonylamino]acetate obtained by the same manner as in Reference example 1-(e) and 2.24 ml (16.2 mmol) of triethylamine, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, to the reaction mixture was added a 5percent aqueous potassium hydrogen sulfate solution, and the mixture was extracted with chloroform. The organic layer was successively washed with a saturated aqueous sodium hydrogen carbonate solution and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was applied to silica gel column chromatography (eluent; n-hexane:ethyl acetate=1:1–>1:2 (V/V)), and the fractions containing the objective material were concentrated under reduced pressure to obtain 1.45 g of the title compound as colorless oil. (Yield: 85percent) Mass spectrum (CI, m/z): 479 (M++1). 1H-NMR spectrum (CDCl3, delta ppm): 9.06 (d, J=2.2 Hz, 1H), 8.71 (dd, J=4.6, 1.5 Hz, 1H), 8.13-8.08 (m, 1H), 7.68 (d, J=8.2 Hz, 1H), 7.52 (dd, J=8.2, 7.4 Hz, 1H), 7.38-7.32 (m, 1H), 6.77 (d, J=7.4 Hz, 1H), 5.80 (t, J=5.1 Hz, 1H), 4.40 (s, 2H), 4.24 (d, J=5.1 Hz, 2H), 1.53 (s, 9H), 1.46 (s, 9H).

The synthetic route of 16133-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ube Industries, Ltd.; EP2476678; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 16133-25-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16133-25-8, name is Pyridine-3-sulfonyl chloride. A new synthetic method of this compound is introduced below.

In 500m reaction flask, 200ml of acetonitrile was added,5- (2-fluorophenyl) -1H-pyrrole-3-carbonitrile (50 g, 0.27 mol),N, N-diisopropylethylamine (41.6 g 0.32 mol) and4-N, N-dimethylaminopyridine (4.69 g, 38.4 mmol),Stir at room temperature. The temperature of the reaction solution was controlled to be not higher than 30 ¡ã C, and a mixed solution of 3-pyridinesulfonyl chloride (52.5 g, 0.29 mol) in 100 ml of acetonitrile was added dropwise.Dropping completed, 25 ¡ã C for 2 hours, the reaction is completed, 300ml of purified water was added to the reaction solution, the reaction temperature was controlled not higher than 30 ¡ã C, the dropwise addition of concentrated hydrochloric acid to adjust the pH to 4-5, 25 ¡ã C with stirring 2 hours, filtered, washed with a mixture of acetonitrile and water, and the solid was collected and dried under reduced pressure at 50 ¡ã C to give 79.5 g of 5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) 3-Nitrile yield 90 ? 5percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16133-25-8, its application will become more common.

Reference:
Patent; Shandong Kangmeile Pharmaceutical Technology Co., Ltd.; Geng Fengluan; Liu Yunfeng; Liu Xiaojun; (8 pag.)CN104860923; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16133-25-8, name is Pyridine-3-sulfonyl chloride, molecular formula is C5H4ClNO2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Pyridine-3-sulfonyl chloride

I4- |2-(2,4-dichlorophenyl)-5-methyl-4-[(piperidin- 1 -ylamino)carbonvil- lH-imidazol- 1 – vUphenyl pyridine-3 -sulfonate 2-(2,4-Dichlorophenyl)- 1 -(4-hydroxyphenyl)-5-methyl-N-piperidin- 1 -yl- lH-imidazole-4- carboxamide, prepared as described in B, Step 1 (100 mg, 0.22 mmol) and triethylamine (0.31 ml, 2.25 mmol) in dichloromethane (5.0 ml) were cooled to -780C. 3- Pyridinesulfonyl chloride (144 mg, 0.67 mmol) was added in small portions to the reaction EPO mixture. The resulting mixture was stirred at -78¡ãC for Ih, and at room temperature overnight. Water was added to the reaction, the phases were separated and the organic phase washed with water and dried. The solvent was removed under reduced pressure and separation by preparatory HPLC gave the title compound (110 mg, 84percent) as a solid. s 1H NMR (400 MHz) delta 8.96 (s, IH), 8.92 (s, IH), 8.09-8.06 (m, IH), 7.89 (s, IH), 7.51- 7.49 (m, IH), 7.36 (d, IH), 7.30-7.25 (m, 2H), 7.06 (s, 4H), 2.88-2.84 (m, 4H), 2.48 (s, 3H), 1.79-1.74 (m, 4H), 1.47-1.41 (m, 2H). MS m/z 586 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 16133-25-8.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/31720; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 16133-25-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16133-25-8 as follows.

Example 64Pyridine-3-sulfonic acid [3-(4,4-dimethyl-6-trifluoromethyl-l,2,3,4-tetrahydro- quinolin-2-yl)-phenyl]-amideTo a stirred solution of 3-(4,4-dimethyl-6-trifluoromethyl-l,2,3,4-tetrahydro-quinolin-2-yl)- phenylamine (150 mg, 0.47 mmol) in pyridine (0.74 mg, 0.94 mmol) and dichloromethane (3 mL) at 0¡ãC was added dropwise a solution of pyridine-3-sulfonyl chloride (100 mg, 0.56 mmol) in dichloromethane (1 mL). The mixture was stired at room temperature overnight. Thin layer chomatography and LC-MS indicated that 3-(4,4,6-trimethyl-l,2,3,4-tetrahydro- quinolin-2-yl)-phenylamine was consumed completely. The mixture was quenched with water (5 mL) and extracted with dichloromethane (5 mL x 2). The combined organic layers were dried over anhydrous sodium sulfate and evaporated. The residue was purified by column chomatography on silica gel to afford pyridine-3 -sulfonic acid [3-(4,4-dimethyl-6- trifluoromethyl-l,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide (170 mg, 78.7percent) as a white solid. MS (ESI+APCI) M+l=442.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16133-25-8, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; FENG, Lichun; HUANG, Mengwei; LIU, Yongfu; WU, Guolong; ZHOU, Mingwei; WO2012/52372; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16133-25-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16133-25-8, name is Pyridine-3-sulfonyl chloride. This compound has unique chemical properties. The synthetic route is as follows.

Under the protection of the Ar, 3 – pyridine sulfonyl chloride (1.457 g) is added in excess ammonia water (4.5 ml, ammonia content: 25 – 28percent), the temperature of the 40 ¡ãC reaction, 30 min after stopping the reaction, steaming and the removal of unreacted ammonia, adding 10 ml water precipitated yellow solid, filtering ethanol after heats crystallization (1.1 g, 85percent),

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16133-25-8, Pyridine-3-sulfonyl chloride.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Shen Zhufang; Bie Jianbo; Mu Yongzhao; Chen Hualong; Liu Lvnan; Zhou Jie; Li Caina; Cao Ran; Huan Yi; Sun Shujuan; (258 pag.)CN107098846; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem