Category: 16135-36-7

Electric Literature of 16135-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16135-36-7, name is Methyl 4-aminonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 4 Following the procedure of Example 1, but substituting an equivalent amount of methyl 4-amino-nicotinate for methyl 2-amino-nicotinate and using methylene chloride as eluent for the column chromatography, methyl 4-(2-acetylthiomethyl-propionamido)-nicotinate is obtained; m.p. 55-57 C., from petroleum ether.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16135-36-7, Methyl 4-aminonicotinate.

Reference:
Patent; Simes, Societa Italiana Medicinalle Sintetici; US4528296; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 16135-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16135-36-7, name is Methyl 4-aminonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of dichloromethane (100 mL), 4-amino-nicotinic acid methyl ester (4.60 g, 30.2 [MMOL)] and diisopropylethyl amine (8.25 mL, 46.7 [MMOL),] was added (1-fluorocarbonyl-2-methyl-propyl)-carbamic acid benzyl ester (11.8 g, 46.7 [MMOL)] at room temperature and the mixture stirred overnight. The solvent was removed under reduced pressure and the residue purified by flash silica gel chromatography using hexane-EtOAc (stepwise gradient from 3: 1 to 1: 1) as eluents to obtain the desired amide of Formula 506, 4- (2-benzyloxycarbonylamino-3-methyl- butyrylamino)-nicotinic acid methyl ester (10.5 g, 90. 1%). MS [(CI)] M/E: 386.2.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16135-36-7, Methyl 4-aminonicotinate.

Reference:
Patent; CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION; WO2003/103575; (2003); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 16135-36-7, Methyl 4-aminonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Methyl 4-aminonicotinate, blongs to pyridine-derivatives compound. Safety of Methyl 4-aminonicotinate

TBTU (1.99 g, 6.19 mmol) was added to a stirred solution of 2′-ethoxy-biphenyl-4-carboxylic acid (1.00 g, 4.13 mmol) and triethylamine (1.73 mL, 12.4 mmol) in dichloromethane (50 mL). After 2 min, 4-amino-nicotinic acid methyl ester (628 mg, 4.13 mmol) was added, and the mixture was heated to reflux for 1 d then allowed to stand at rt for another 2 d. After washing with 1 M aq NaOH (25 mL), water (25 mL) and brine (25 mL the solution was concentrated under reduced pressure. The residue was purified by flash chromatography (silica, 100% DCM to 97:3 DCM/MeOH). Yield 1359 mg (87%). HR-MS (m/z): C22 H20 N2 O4, calcd [M+H]+, 377.1501, found 377.1509.1H NMR (500 MHz, CDCl3) delta 12.21 (s, 1H), 9.24 (s, 1H), 8.93 (d, J = 5.7 Hz, 1H), 8.67 (d, J = 5.4 Hz, 1H), 8.08 (d, J = 8.5 Hz, 2H), 7.76 (d, J = 8.5 Hz, 2H), 7.39 – 7.33 (m, 2H), 7.06 (td, J = 7.5, 0.9 Hz, 1H), 7.01 (d, J = 8.1 Hz, 1H), 4.08 (q, J = 7.0 Hz, 2H), 4.05 (s, 3H), 1.37 (t, J = 7.0 Hz, 3H).

The synthetic route of 16135-36-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bauer, Udo; Giordanetto, Fabrizio; Bauer, Martin; O’Mahony, Gavin; Johansson, Kjell E.; Knecht, Wolfgang; Hartleib-Geschwindner, Judith; Carlsson, Eva Toeppner; Enroth, Cristofer; Bioorganic and Medicinal Chemistry Letters; vol. 22; 5; (2012); p. 1944 – 1948;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 16135-36-7, Methyl 4-aminonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 4-chloro-5-isopropenyl-2 -phenyl-pyridine (1.2 g, 5.24 mmol), methyl 4- aminopyridine-3-carboxylate (795 mg, 5.225 mmol) and Cs2C03 (3.40 g, 10.435 mmol) in dioxane (30 mL) was purged with nitrogen for 30 min, followed by addition of Pd2(dba)3 (478 mg, 0.521 mmol) and xantphos (604 mg, 1.043 mmol) and again purged with nitrogen for 5 min. The reaction mixture was heated at 100 C overnight. The progress of reaction was monitored over LCMS. After completion of the reaction, the reaction mixture was diluted with water (100 mL) and extracted with EtOAc (2×150 mL). The combined organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford a crude product, which was purified by column chromatography on silica gel (100-200 mesh) using 20% EtOAc- hexane as eluent to obtain methyl 4-[(5-isopropenyl-2-phenyl-4- pyridyl)amino]pyridine-3-carboxylate (500 mg) as a yellow sticky semi-solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16135-36-7, Methyl 4-aminonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; PUJALA, Brahmam; SHINDE, Bharat Uttam; NAYAK, Anjan Kumar; CHAKLAN, Naveen; AGARWAL, Anil Kumar; RAMACHANDRAN, Sreekanth A.; PHAM, Son; WO2015/103355; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 16135-36-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16135-36-7, name is Methyl 4-aminonicotinate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.

4- [2-(5-Chloro-2-fluoro-phenyl)-7-(2-dimethylamino-ethylamino)-pyrido [2,3-d] – pyrimidin-4-ylamino] -nicotinic acid methyl ester. Crude imino halide, N’-[4-Chloro-2-(5-chloro-2-fluoro-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-N,N- dimethyl-ethane-l,2-diamine (0.58 g) dissolved in dioxane (80ml) was added Pd(OAc)2 (0.077 g) followed by BINAP (0.115 g), 4-amino-pyridyl-3-carboxylate (0.232 g) and Cs2CO3 (0.748 g). The reaction mixture was heated to 8O0C for 15h. The reaction mixture was cooled to r.t. and filtered through Celite and the crude material was purified by silica gel flash column chromatography (3:2/ethyl acetate:hexane) to give 4-[2-(5-Chloro-2-fluoro-phenyl)-7-(2-dimethylamino-ethylamino)-pyrido[2,3-d]- pyrimidin-4-ylamino] -nicotinic acid methyl ester (0.300 g).

The chemical industry reduces the impact on the environment during synthesis 16135-36-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD; WO2006/100310; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16135-36-7, name is Methyl 4-aminonicotinate, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C7H8N2O2

To a stirring suspension of methyl 4-aminopyridine-3- carboxylate (0.10 g, 0.659 mmol) in dichloromethane(1 mL) was added a solution of4-tert-butyl-2- (1-Boc-piperidin-4- yloxy) benzoyl chloride (1.3 mmol) in dichloromethane (6 mL), followed byN, N-diisopropylethylamine (0.15 mL, 0.8 mmol) and 4-N, N-dimethylaminopyridine (0. 0084 g, 0.068 mmol). After stirring overnight, the solution was diluted with ethyl acetate and washed three times with satd aqNaHCO3. The combined aq phase was back extracted with ethyl acetate and the combined organic phase was dried withMgSO4, filtered and concentrated in vacuo. The residue was chromatographed over silica gel, eluting with a gradient of 30% ethyl acetate in hexanes through 100% ethyl acetate. The product containing fractions were combined and concentrated in vacuo to give the title compound (0.223 g, 66%) as a thick yellow syrup. 1NMR IS-MS, m/e 512.3(m+1)

With the rapid development of chemical substances, we look forward to future research findings about 16135-36-7.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/49604; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 16135-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16135-36-7, name is Methyl 4-aminonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-chloro-2-(5-chloro-2-fluoro-phenyl)-5-(l-methoxy-l-methyl- ethyl)pyridine (200 mg, 0.636 mmol), methyl 4-aminopyridine-3 -carboxylate (107 mg, 0.703 mmol) and K3P04 (270 mg, 1.271 mmol) in dioxane (1.5 mL) was purged with nitrogen for 10 min, followed by addition of Pd2(dba)3 (58 mg, 0.063 m mol) and Xantphos (74 mg, 0.127 mmol) and again purged for 2 min. The reaction mixture was heated in a microwave at 100 C for 2 h. The progress of reaction was monitored by TLC and LCMS. After completion of reaction, the mixture was diluted with EtOAc (15 mL) and washed with water (2×10 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford a crude product. The crude product was purified by CombiFlash using 25% EtOAc-hexane as eluent to obtain methyl 4-[[2-(5-chloro-2-fluoro-phenyl)-5-(l-methoxy-l-methyl- ethyl)-4-pyridyl]amino]pyridine-3-carboxylate (42 mg).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16135-36-7, Methyl 4-aminonicotinate.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; PUJALA, Brahmam; SHINDE, Bharat Uttam; NAYAK, Anjan Kumar; CHAKLAN, Naveen; AGARWAL, Anil Kumar; RAMACHANDRAN, Sreekanth A.; PHAM, Son; WO2015/103355; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem