Category: 1620-75-3

Synthetic Route of 1620-75-3 ,Some common heterocyclic compound, 1620-75-3, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 6-methylpyridine-2-carbonitrile (1 g, 8.46 mmol, 1 eq) in CCU (15 mL) was added NBS (1.51 g, 8.46 mmol, 1 eq) and AIBN (139.0 mg, 0.84 mmol, 0.1 eq). The mixture was stirred at 80 C for 16 hr. The reaction mixture was added H20 (30 mL) and extracted with EA (30 mL * 3). The combined organic layers were washed with brine (30 mL), dried with anhydrous Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography (40 g SepaFlash Silica Flash Column, EA/PE: 0-10%) to afford two main spots. To afford 6-(bromomethyl)pyridine-2-carbonitrile (979 mg, crude) as yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1620-75-3, its application will become more common.

Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (472 pag.)WO2020/97389; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1620-75-3, Adding some certain compound to certain chemical reactions, such as: 1620-75-3, name is 6-Methylpicolinonitrile,molecular formula is C7H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1620-75-3.

Synthesis of 2-bromomethyl-6-cyanopyridine or compound 7 A solution of 400 mg (3.39 mmol) of 2-cyano-6-methylpyridine in 12 ml of CHCl3 is admixed with 723 mg (4.06 mmol) of N-bromosuccinimide (NBS) and 28 mg (0.17 mmol) of azobisisobutyronitrile (AIBN). The resulting orange-brown suspension is refluxed and irradiated with a UV lamp for 4 hours (the reaction is monitored by TLC on silica plates, using CH2Cl2 as eluant-Rf=0.43). The reaction mixture is cooled to ambient temperature and the solvent is evaporated under reduced pressure. The crude product is purified by chromatography on a silica gel column, using a continuous gradient from an 85/15 v/v CH2Cl2/heptane mixture to pure CH2Cl2 as eluant. This gives 290 mg of compound 7 in the form of a white microcrystalline powder (yield: 43%). 1H NMR (200 MHz, CDCl3) delta ppm: 4.55 (s, 2H, pyCH2Br), 7.63 (dd, J=7.63, 1.27 Hz, 1H, H3), 7.70 (dd, J=7.95, 1.27 Hz, 1H, H1), 7.87 (t, J=7.95Hz, 7.63Hz, 1H, H2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1620-75-3, 6-Methylpicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Giraud, Marion; Demadrille, Renaud; Mazzanti, Marinella; Andreiadis, Eugen Sorin; US2011/112289; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem