Category: 1620-76-4

Zhong, Jing et al. published their research in Organic Letters in 2019 | CAS: 1620-76-4

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C7H6N2

Rhodium-Catalyzed Pyridine N-Oxide Assisted Suzuki-Miyaura Coupling Reaction via C(O)-C Bond Activation was written by Zhong, Jing;Long, Yang;Yan, Xufei;He, Shiyu;Ye, Runyou;Xiang, Haifeng;Zhou, Xiangge. And the article was included in Organic Letters in 2019.Synthetic Route of C7H6N2 This article mentions the following:

A rhodium-catalyzed Suzuki-Miyaura coupling reaction via C(O)-C bond activation to form 2-benzoylpyridine N-oxide derivatives is reported. Both the C(O)-C(sp2) and C(O)-C(sp3) bond could be activated during the reaction with yields up to 92%. The N-oxide moiety could be employed as a traceless directing group, leading to free pyridine ketones. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Synthetic Route of C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Liyan et al. published their research in Huagong Xuebao (Chinese Edition) in 2007 | CAS: 1620-76-4

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C7H6N2

Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines was written by Dai, Liyan;Fang, Jun;Wang, Xiaozhong;Chen, Yingqi. And the article was included in Huagong Xuebao (Chinese Edition) in 2007.Computed Properties of C7H6N2 This article mentions the following:

The preparation of a series of 2-pyridinamines and their alkyl derivatives is described. The target compounds are synthesized starting from corresponding 2-cyanopyridines, via incomplete hydrolysis in the presence of hydrogen peroxide in the dilute alk. mixture of acetone-2% sodium hydroxide solution, and Hoffmann degradation reaction with freshly made NaBrO. This route is of industrial value because of cheap and readily available materials, moderate reaction conditions and convenient operations. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Computed Properties of C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhong, Jing et al. published their research in Organic Letters in 2019 | CAS: 1620-76-4

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C7H6N2

Rhodium-Catalyzed Pyridine N-Oxide Assisted Suzuki-Miyaura Coupling Reaction via C(O)-C Bond Activation was written by Zhong, Jing;Long, Yang;Yan, Xufei;He, Shiyu;Ye, Runyou;Xiang, Haifeng;Zhou, Xiangge. And the article was included in Organic Letters in 2019.Synthetic Route of C7H6N2 This article mentions the following:

A rhodium-catalyzed Suzuki-Miyaura coupling reaction via C(O)-C bond activation to form 2-benzoylpyridine N-oxide derivatives is reported. Both the C(O)-C(sp2) and C(O)-C(sp3) bond could be activated during the reaction with yields up to 92%. The N-oxide moiety could be employed as a traceless directing group, leading to free pyridine ketones. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Synthetic Route of C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Liyan et al. published their research in Huagong Xuebao (Chinese Edition) in 2007 | CAS: 1620-76-4

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C7H6N2

Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines was written by Dai, Liyan;Fang, Jun;Wang, Xiaozhong;Chen, Yingqi. And the article was included in Huagong Xuebao (Chinese Edition) in 2007.Computed Properties of C7H6N2 This article mentions the following:

The preparation of a series of 2-pyridinamines and their alkyl derivatives is described. The target compounds are synthesized starting from corresponding 2-cyanopyridines, via incomplete hydrolysis in the presence of hydrogen peroxide in the dilute alk. mixture of acetone-2% sodium hydroxide solution, and Hoffmann degradation reaction with freshly made NaBrO. This route is of industrial value because of cheap and readily available materials, moderate reaction conditions and convenient operations. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Computed Properties of C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

09/26/21 News Share a compound : 1620-76-4

The synthetic route of 1620-76-4 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1620-76-4, name is 4-Methylpicolinonitrile, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H6N2

Reference Example 55 4-Methyl-2-pyridinecarbaldehyde diisobutyl aluminium hydride in toluene (1.5 M, 43.5 ml, 65 mmol) was added dropwise to a solution of 2-cyano-4-methylpyridine (7.0 g, 59 mmol) in dichloromethane (180 ml) at -78 C, and the mixture was stirred at the same temperature for 2 hrs.. The reaction mixture was combined with concentrated hydrochloric acid (28 ml) and water (112 ml), and the water layer and the organic layer were separated.. The organic layer was extracted with 2 N hydrochloric acid.. The water layer was combined, neutralized with sodium hydrogen carbonate and extracted with diethyl ether.. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated to give the titled compound (2.7 g, 37 %).

The synthetic route of 1620-76-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1424336; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

09/26/21 News Share a compound : 1620-76-4

The synthetic route of 1620-76-4 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1620-76-4, name is 4-Methylpicolinonitrile, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H6N2

Reference Example 55 4-Methyl-2-pyridinecarbaldehyde diisobutyl aluminium hydride in toluene (1.5 M, 43.5 ml, 65 mmol) was added dropwise to a solution of 2-cyano-4-methylpyridine (7.0 g, 59 mmol) in dichloromethane (180 ml) at -78 C, and the mixture was stirred at the same temperature for 2 hrs.. The reaction mixture was combined with concentrated hydrochloric acid (28 ml) and water (112 ml), and the water layer and the organic layer were separated.. The organic layer was extracted with 2 N hydrochloric acid.. The water layer was combined, neutralized with sodium hydrogen carbonate and extracted with diethyl ether.. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated to give the titled compound (2.7 g, 37 %).

The synthetic route of 1620-76-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1424336; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 4-Methylpicolinonitrile

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1620-76-4, 4-Methylpicolinonitrile, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1620-76-4, name is 4-Methylpicolinonitrile, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.category: pyridine-derivatives

A solution of 2-cyano-4-methyl pyridine (0.15 g, 1.27 mmol) in about 10 mL of 6 M HCl was heated under reflux for 24 h. During this time, the initially light yellow solution changed to a clear solution. The solution was evaporated to dryness to leave a white solid. The solid was recrystallized from a minimal amount of distilled water to give a yield of 148 mg (85 %) . 1H NMR (DMSO-dff) : delta = 8.65 (IH, s), 8.06 (IH, s), 7.66 (IH, s) 2.05 (3H, s)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1620-76-4, 4-Methylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; THE UNIVERSITY OF WARWICK; SADLER, Peter, John; PEACOCK, Anna, Frances, Acushla; VAN RIJT, Sabine, Helena; HABTEMARIAM, Abraha; WO2008/17855; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 1620-76-4

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1620-76-4, 4-Methylpicolinonitrile.

Application of 1620-76-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1620-76-4, name is 4-Methylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

II-3-2: Synthesis of 4-methylpicolinic acid A solution of 0.80 g (6.8 mmol) of 2-cyano-4-methylpyridine dissolved in 10.0 g of sulfuric acid was stirred under heating at 120 C. for 2 hours and then cooled to 20 C. A solution of 4.00 g of sodium sulfite in 8 ml of water was dropwise added at 20 to 25 C., and heated at the same temperature for 1.5 hours, and further, at 75 to 85 C. for 1.5 hours. After cooling, sodium carbonate was added to adjust the pH to about 3, and the mixture was extracted with chloroform. After drying over anhydrous sodium sulfate, the extract was concentrated under a reduced pressure and the residue recrystallized from an ethyl acetate hexane mixture to give 0.50 g of crystals (yield 53.8%). m.p.: 127-128 C. IR (KBr): 3400, 3150, 2600, 2150, 1590, 1515 cm-1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1620-76-4, 4-Methylpicolinonitrile.

Reference:
Patent; Shiseido Company, Ltd.; US5219847; (1993); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem