Category: 1620-77-5

Electric Literature of 1620-77-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1620-77-5, name is 5-Methylpicolinonitrile, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

[5-METHYL-PYRIDINE-2-CARBONITRILE] (3.34 g, 28.3 mmol) was mixed with [18] percent HCl (12 ml) and ethanol [(6ML)] and refluxed for 40 h. The reaction mixture was concentrated by rotavapor and the residue was triturated with acetone to give off-white solid 5-methyl-pyridine-2- carboxylic acid hydrochloride. This solid was hydrogenated with [PT02] in ethanol for 2 days until no W active material left. The reaction mixture was filtered, concentrated by vacuum. The residue was triturated with acetone to give 5.3 g of cis and trans 5-methyl- piperidine-2-carboxylic acid hydrochloride as white solid (quantitative).

Statistics shows that 1620-77-5 is playing an increasingly important role. we look forward to future research findings about 5-Methylpicolinonitrile.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14902; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1620-77-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1620-77-5, name is 5-Methylpicolinonitrile. A new synthetic method of this compound is introduced below.

Synthesis Example 1 Ethyl 5-methylpyridine-2-carboxylate STR24 200 ml of ethanol and 100 ml (1.88 mol) of concentrated sulfuric acid were added to 55.5 g of 5-methylpyridine-2-carbonitrile to form a homogeneous solution, followed by heating under reflux for 2 days. The reaction liquid was gradually poured into a saturated aqueous solution of sodium hydrogencarbonate under cooling with ice to neutralize the sulfuric acid, followed by extraction with dichloromethane. The organic layer was washed with a saturated aqueous solution of common salt and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in a reduced pressure to give 78.1 g of a brown oil of the title compound as the crude product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1620-77-5, its application will become more common.

Reference:
Patent; Eisai Co., Ltd.; US5789403; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1620-77-5, 5-Methylpicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1620-77-5, blongs to pyridine-derivatives compound. SDS of cas: 1620-77-5

The compound of Example 4A (13 g, 110 mmol) is dissolved in 400 ml tetrachloro- methane, and 29.4 g (165 mmol) N-bromosuccinimide and 0.4 g (1.6 mmol) dibenzoylperoxide are added. The reaction reaction mixture is refluxed for three hours, cooled down to room temperature and filtered. The solution is washed with aqueous sodium thiosulfate, dried over magnesium sulfate, and the solvent is removed in [VACUO.] The residue is dissolved in 200 ml [DIOXANE AND] 200 ml water, calciumcarbonate (44 g, 440 mmol) is added, and the mixture is stirred at reflux for 2 hours. After cooling down to room temperature, the mixture is filtered, and dichloro- methane is added. After phase separation, the organic phase is dried over magnesium sulfate, and the solvent is removed in vacuo. The product is purified by chromato- graphy (silica, eluent [CYCLOHEXANE/ETHYL] acetate 2: 1). Yield : 5.2 g (35% [OF TH.)] [1H-NMR] (300 MHz, DMSO-d6): [8] = 4.7 (d, 2H), 5.6 (t, [1H),] 8.0 (m, 2H), 8.7 (s, 1H) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1620-77-5, 5-Methylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; BAYER HEALTHCARE AG; WO2004/24700; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem