Category: 164464-60-2

Luise, Nicola published the artcileDiversity-oriented synthesis of bicyclic fragments containing privileged azines, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(2), 248-251, database is CAplus and MEDLINE.

An innovative and efficient reagent- and scaffold-based diversity oriented synthesis (DOS) of a fragment set was developed for fragment-based drug discovery (FBDD) programs. Twelve diverse, functionalized and bicyclic scaffolds were rapidly accessed by adopting a convenient synthetic toolkit around three privileged azine cores in order to effectively modulate biomols. These structures are characterized by both key motifs for interacting with diverse biol. targets via hydrogen bonds and useful points of growth for subsequent fragment optimization.

Bioorganic & Medicinal Chemistry Letters published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C9H10ClNO2, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Luise, Nicola published the artcileDiversity-oriented synthesis of bicyclic fragments containing privileged azines, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(2), 248-251, database is CAplus and MEDLINE.

An innovative and efficient reagent- and scaffold-based diversity oriented synthesis (DOS) of a fragment set was developed for fragment-based drug discovery (FBDD) programs. Twelve diverse, functionalized and bicyclic scaffolds were rapidly accessed by adopting a convenient synthetic toolkit around three privileged azine cores in order to effectively modulate biomols. These structures are characterized by both key motifs for interacting with diverse biol. targets via hydrogen bonds and useful points of growth for subsequent fragment optimization.

Bioorganic & Medicinal Chemistry Letters published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C9H10ClNO2, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chonan, Tomomichi published the artcileDiscovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group, Recommanded Product: Ethyl 2-(2-chloropyridin-3-yl)acetate, the publication is Bioorganic & Medicinal Chemistry (2011), 19(5), 1580-1593, database is CAplus and MEDLINE.

Novel (4-piperidinyl)-piperazine derivatives were synthesized and evaluated as ACC1/2 non-selective inhibitors. Optimization of the substituents on the nitrogen of the piperidine ring led to the identification of the fluorine substituted tert-butoxycarbonyl group. Advanced analog, 1,1,1-trifluoro-2-methylpropan-2-yl 4-{4-[(2-amino-6-methyl-1-benzothiophen-3-yl)carbonyl]piperazin-1-yl}piperidine-1-carboxylate (12c (I)) showed potent inhibitory activities in enzyme-assay and cell-based assays. Compound 12c also exhibited reduction of hepatic de novo fatty acid synthesis in rats after oral administration.

Bioorganic & Medicinal Chemistry published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C9H10ClNO2, Recommanded Product: Ethyl 2-(2-chloropyridin-3-yl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shen, Zican published the artcileGeneral Light-Mediated, Highly Diastereoselective Piperidine Epimerization: From Most Accessible to Most Stable Stereoisomer, Computed Properties of 164464-60-2, the publication is Journal of the American Chemical Society (2021), 143(1), 126-131, database is CAplus and MEDLINE.

We report a combined photocatalytic and hydrogen atom transfer (HAT) approach for the light-mediated epimerization of readily accessible piperidines to provide the more stable diastereomer with high selectivity. The generality of the transformation was explored for a large variety of di- to tetrasubstituted piperidines with aryl, alkyl, and carboxylic acid derivatives at multiple different sites. Piperidines without substitution on nitrogen as well as N-alkyl and aryl derivatives were effective epimerization substrates. The observed diastereoselectivities correlate with the calculated relative stabilities of the isomers. Demonstration of reaction reversibility, luminescence quenching, deuterium labeling studies, and quantum yield measurements provide information about the mechanism.

Journal of the American Chemical Society published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C5H11NO2S, Computed Properties of 164464-60-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bremner, D. H. published the artcileThe synthesis of thienopyridines from ortho-halogenated pyridine derivatives. Part 2, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate, the publication is Synthesis (1997), 949-952, database is CAplus.

Synthetic routes to 2- and 4-chloro-3-pyridylacetate, 3-bromo-4-pyridylacetate, and 3-bromo-2-pyridylacetate containing methylene groups activated by the ester functionality are reported. Reaction of these pyridines with CS₂ in the presence of NaH, followed by quenching with MeI results in the formation of the corresponding thienopyridines in moderate yields.

Synthesis published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C9H10ClNO2, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sturrock, Keith R. published the artcileThe preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group, COA of Formula: C9H10ClNO2, the publication is Heterocycles (2011), 82(2), 1657-1662, database is CAplus.

The base-catalyzed reaction of CS₂ with the active methylene groups of 6-chloropyridine-3-acetonitrile and -3-acetate, followed by alkylation with reagents also containing active methylene groups, led to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.

Heterocycles published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C9H17NO, COA of Formula: C9H10ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem