Category: 1658-42-0

Application of 1658-42-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.

Example 6 1-Adamantan-2-yl-3-cyclopropyl-4-pyridin-2-yl-1,3-dihydro-imidazol-2-one Step A1 Cyclopropylamino-pyridin-2-yl-acetic acid methyl ester; This material was obtained in analogy to example 4, step A] from alpha-bromo-pyridin-2-yl-acetic acid methyl ester (1.0 g, CAS 52458-81-8, made by bromination of pyridine-2-yl-acetic acid methyl ester according to Tetrahedron, 58, 2002, 10113-10126) and cyclopropylamine (372 mg) to cyclopropylamino-pyridin-2-yl-acetic acid methyl ester as a light yellow liquid (515 mg). MS (ESI): 206.9 (MH+).

Statistics shows that 1658-42-0 is playing an increasingly important role. we look forward to future research findings about Methyl 2-(pyridin-2-yl)acetate.

Reference:
Patent; Ackermann, Jean; Amrein, Kurt; Hunziker, Daniel; Kuhn, Bernd; Mayweg, Alexander V.; Neidhart, Werner; Takahashi, Tadakatsu; US2008/103183; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1658-42-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.

Example 6 1-Adamantan-2-yl-3-cyclopropyl-4-pyridin-2-yl-1,3-dihydro-imidazol-2-one Step A1 Cyclopropylamino-pyridin-2-yl-acetic acid methyl ester; This material was obtained in analogy to example 4, step A] from alpha-bromo-pyridin-2-yl-acetic acid methyl ester (1.0 g, CAS 52458-81-8, made by bromination of pyridine-2-yl-acetic acid methyl ester according to Tetrahedron, 58, 2002, 10113-10126) and cyclopropylamine (372 mg) to cyclopropylamino-pyridin-2-yl-acetic acid methyl ester as a light yellow liquid (515 mg). MS (ESI): 206.9 (MH+).

Statistics shows that 1658-42-0 is playing an increasingly important role. we look forward to future research findings about Methyl 2-(pyridin-2-yl)acetate.

Reference:
Patent; Ackermann, Jean; Amrein, Kurt; Hunziker, Daniel; Kuhn, Bernd; Mayweg, Alexander V.; Neidhart, Werner; Takahashi, Tadakatsu; US2008/103183; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1658-42-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1658-42-0 as follows.

General procedure: An oven-dried Schlenk tube was charged with Pd(OAc)2 (0.015 mmol, 3.4 mg), X-Phos (0.015 mmol, 7.2 mg), Cs2CO3 (0.9 mmol, 293 mg), substrate 1 (0.3 mmol) and 2 (0.4 mmol). The reaction vessel was evacuated and backfilled again with nitrogen gas, and 1,4-dioxane (1 mL) was added via syringe under nitrogen. The reaction mixture was stirred at 100 C for 12 hours. The reaction mixture was then cooled to room temperature and diluted with EtOAc. The crude was nextfiltered through a plug of celite, which was washed with ethyl acetate. The solution was concentrated and further purifiedby flash column chromatography to afford the corresponding product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1658-42-0, its application will become more common.

Reference:
Article; Jin, Chaochao; Xu, Kun; Fan, Xiao; Liu, Changyao; Tan, Jiajing; Chinese Chemical Letters; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1658-42-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.

Hydrazine (4.15 mL, 132 mmol) was added to a ethanol (66 mL) solution of methyl 2-(pyridin-2-yi)acetate (10 g, 66.2 mmol) at r.t. The mixture was heated and stirred at 85 C for 4 h, and then cooled to r.t. White solid was formed upon standing, which was collected via filtration and used in next step without further purification. LCMS calculated for CTHJ ONSO (M+H)+: 152.1. Found: 152.0.

The chemical industry reduces the impact on the environment during synthesis 1658-42-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; INCYTE CORPORATION; WANG, Xiaozhao; GAN, Pei; HAN, Heeoon; HUANG, Taisheng; MCCAMMANT, Matthew S.; QI, Chao; QIAN, Ding-Quan; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHANG, Fenglei; (284 pag.)WO2019/168847; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate. A new synthetic method of this compound is introduced below., Formula: C8H9NO2

General procedure: A mixture of phenylethynylbromide (1a) (1.0 mmol), ethyl2-pyridylacetate (2a) (0.6 mmol), AgNO3 (34.0 mg, 0.2 mmol, 0.2 equiv.), DABCO(70.0 mg, 1.0 mmol, 1.0 equiv.) in DMSO (3.0 mL) in a test tube (25 mL)equipped with a magnetic stirring bar. The mixture was stirred at 100 oCfor 12 h. After the reaction was completed, the mixture was washed with brineand extracted with ethyl acetate. The organic layer was dried (MgSO4),concentrated in vacuum and purified by flash silica gel chromatography usingpetroleum ether/ethyl acetate 10:1 to give the desired products.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1658-42-0, Methyl 2-(pyridin-2-yl)acetate.

Reference:
Article; Zeng, Wei; Wu, Wanqing; Jiang, Huanfeng; Sun, Yadong; Chen, Zhengwang; Tetrahedron Letters; vol. 54; 35; (2013); p. 4605 – 4609;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1658-42-0, Adding some certain compound to certain chemical reactions, such as: 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1658-42-0.

To a stirred solution of methyl 2-(pyridin-2-yl)acetate (190 g, 1.260 mol) in 1,4- dioxane (1.9 L) was added Triton-B (Benzyl Trimethyl ammonium hydroxide) (46 mL, 0.252 mol) at room temperature and stirred for 10 min. Acrylonitrile (49.7 mL, 0.760 mol) was dissolved in 1,4-dioxane (0.9 L) and was added drop wise over period of 30 minutes. The resulting reaction mixture was stirred for 16 hr at room temperature. The reaction progress was monitored by TLC. After completion of the reaction (TLC), the reaction mixture was concentrated under reduced pressure to afford the crude title compound. Purification by column chromatography was by using (100-200 silica gels) using 15 percent ethyl acetate and pet. ether as the eluent afforded pure compound.

According to the analysis of related databases, 1658-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MANDAL, Mihir; TANG, Haifeng; XIAO, Li; SU, Jing; LI, Guoqing; YANG, Shu-Wei; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; HICKS, Jacqueline; LOMBARDO, Matthew; CHU, Hong; HAGMANN, William; PASTERNAK, Alex; GU, Xin; JIANG, Jinlong; DONG, Shuzhi; DING, Fa-Xiang; LONDON, Clare; BISWAS, Dipshikha; YOUNG, Katherine; HUNTER, David, N.; ZHAO, Zhiqiang; YANG, Dexi; WO2015/112441; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1658-42-0, Adding some certain compound to certain chemical reactions, such as: 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1658-42-0.

General procedure: A mixture of phenylethynylbromide (1a) (1.0 mmol), ethyl2-pyridylacetate (2a) (0.6 mmol), AgNO3 (34.0 mg, 0.2 mmol, 0.2 equiv.), DABCO(70.0 mg, 1.0 mmol, 1.0 equiv.) in DMSO (3.0 mL) in a test tube (25 mL)equipped with a magnetic stirring bar. The mixture was stirred at 100 oCfor 12 h. After the reaction was completed, the mixture was washed with brineand extracted with ethyl acetate. The organic layer was dried (MgSO4),concentrated in vacuum and purified by flash silica gel chromatography usingpetroleum ether/ethyl acetate 10:1 to give the desired products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1658-42-0, Methyl 2-(pyridin-2-yl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zeng, Wei; Wu, Wanqing; Jiang, Huanfeng; Sun, Yadong; Chen, Zhengwang; Tetrahedron Letters; vol. 54; 35; (2013); p. 4605 – 4609;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1658-42-0, Methyl 2-(pyridin-2-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Methyl 2-(pyridin-2-yl)acetate, blongs to pyridine-derivatives compound. Safety of Methyl 2-(pyridin-2-yl)acetate

General procedure: Ethyl 2-(pyridin-2-yl)acetate (1a, 0.4 mmol), 1,3-diphenylprop-2-yn-1-yl methyl carbonate (2a, 0.2 mmol),Pd2(dba)3 (0.01 mmol), DBFphos (0.02 mmol), K2CO3 (0.4 mmol)were mixed under N2 atmosphere in DMF (2 mL). The reactiontube was heated in an oil bath at 120 C for 16 h. After completionof the reaction, the reaction mixture was extracted withEtOAc (3 × 15 mL), and the solvent was removed under reducedpressure. The remaining crude product was then purifiedthrough column chromatography using silica gel (EtOAc-petroleumether = 1:5) to afford 3a as a white solid in 65% yield. 1HNMR (500 MHz, CDCl3): delta = 8.24 (dd, J = 9.2, 1.3 Hz, 1 H), 7.53 (d,J = 7.0 Hz, 1 H), 7.23-7.32 (m, 5 H), 7.15 (t, J = 7.3 Hz, 2 H), 7.10(t, J = 7.2 Hz, 1 H), 6.93- 6.99 (m, 3 H), 6.54 (td, J = 6.8, 1.3 Hz, 1H), 4.11 (q, J = 7.1 Hz, 2 H), 4.08 (s, 2 H), 1.06 (t, J = 7.1 Hz, 3 H).13C NMR (125 MHz, CDCl3): delta = 165.2, 137.5, 136.2, 135.4, 131.5,130.5, 128.9, 127.8, 127.7, 127.1, 126.7, 123.4, 122.2, 121.4,120.2, 112.6, 102.0, 59.3, 30.2, 14.3. HRMS (ESI): m/z [M + H]+calcd for C24H22NO2 : 356.1645; found 356.1642

The synthetic route of 1658-42-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Yuzhu; Wu, Ting; Fang, Youlai; Synlett; vol. 29; 14; (2018); p. 1909 – 1913;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1658-42-0, Methyl 2-(pyridin-2-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1658-42-0, blongs to pyridine-derivatives compound. COA of Formula: C8H9NO2

General procedure: In a reaction tube 66.0 mg (0.4 mmol) of ethyl 2-(pyridin-2-yl)acetate (1a), 41.6 mg (0.2 mmol) of 1,3-diphenyl-2-propenone (2b), 12.65 mg (0.05 mmol) of I2 and 58.4 mg (0.4 mmol) of DTBP were added to 1.0 mL of 1,2-dichlorobenzene and stirred the reaction mixture at 120 ¡ãC, after 24 h of the reaction time, the mixture was allowed to attain room temperature, and quenched the I2 with Na2S2O3 solution, after adding 10 mL of brine solution to reaction mixture, the organic portion was extractedwith ethyl acetate (3×10 mL) and combined organic layers dried over anhydrous Na2SO4, crude mixture obtained after removal of ethyl acetate under reduced presure was purified by column chromatography to isolate 3a with 87 percent yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1658-42-0, its application will become more common.

Reference:
Article; Reddy, N. Naresh Kumar; Donthiri, Ramachandra Reddy; Ravi, Chitrakar; Adimurthy, Subbarayappa; Tetrahedron Letters; vol. 57; 30; (2016); p. 3243 – 3246;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate, molecular formula is C8H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1658-42-0

General procedure: In a reaction tube 66.0 mg (0.4 mmol) of ethyl 2-(pyridin-2-yl)acetate (1a), 41.6 mg (0.2 mmol) of 1,3-diphenyl-2-propenone (2b), 12.65 mg (0.05 mmol) of I2 and 58.4 mg (0.4 mmol) of DTBP were added to 1.0 mL of 1,2-dichlorobenzene and stirred the reaction mixture at 120 ¡ãC, after 24 h of the reaction time, the mixture was allowed to attain room temperature, and quenched the I2 with Na2S2O3 solution, after adding 10 mL of brine solution to reaction mixture, the organic portion was extractedwith ethyl acetate (3×10 mL) and combined organic layers dried over anhydrous Na2SO4, crude mixture obtained after removal of ethyl acetate under reduced presure was purified by column chromatography to isolate 3a with 87 percent yield.

With the rapid development of chemical substances, we look forward to future research findings about 1658-42-0.

Reference:
Article; Reddy, N. Naresh Kumar; Donthiri, Ramachandra Reddy; Ravi, Chitrakar; Adimurthy, Subbarayappa; Tetrahedron Letters; vol. 57; 30; (2016); p. 3243 – 3246;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem