Electric Literature of 16727-43-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16727-43-8, name is 2,6-Dimethoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of cis-N2-(4-amino-cyclohexyl)-N4,N4-dimethyl-quinazolin-2,4-diamine (28.5 mg, 0. 1 mmol) in 0. 5 mL ONTF was added 2,6-dimethoxynicotinic acid (18. 3 MG, O. 1 mmol), TU (45. 6mg, 0.12 mmol), and DIEA A (34.8 L, 0.2 mmol), The reaction mixture was stirred for a couple of hours, and the compound was then subjected to purification by prep LCMS to yield N-(cis-4-{[4-(dimelthylamino)quinazolin-2-yl]amino}cyclohexyl)-2,6-dimethoxynicotinamide trifluoroacetate (9. 9 mg, 0. 022 mmol, 22 %) as a white solid. ESI-MS M/E 451.2 M + H+ ; 1H NMR (400 MHZ, DMSO-D6) # 12.5 (S, 1 H), 8.42 (BRS, 1 H), 8.13 (dd, J = 4. 0, 4. 0 Hz, 2 H), 7. 86 (brs, 1 H), 7. 74 (T, J = 8. 0 Hz, 1 H), 7. 39 (BRS, I H), 7. 32 (T, J = 8. 0 HZ, I H), 6. 47 (d, J = 8. 0 HZ. 1 H), 4.02 (s, 3 H), 3.95 (brs, 1 H), 3.85 (s, 3 H), 3. 6S (brs, 1 H), 3. 42 (brs, 6 H), 1.80-1.68 (m, 8 H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16727-43-8, 2,6-Dimethoxynicotinic acid.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; ARENA PHARMACEUTICALS INC.; WO2004/87680; (2004); A1;,
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